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• W1844434462 endingPage "C309" @default.
• W1844434462 startingPage "C302" @default.
• W1844434462 abstract "We recently observed that prostaglandin E(2) (PGE(2))-mediated suppression of T cell functions could result from an attenuation of p59(fyn) protein tyrosine kinase activity. The present study evaluated the effects of an adenylate cyclase agonist (forskolin) and antagonist (SQ-22536), as well as those of cAMP analogues (dibutyryl cAMP and 8-bromo- cAMP), on T cell p59(fyn) kinase activity. The study allowed us to assess whether PGE(2)-mediated activation of adenylate cyclase by itself or the elevation in intracellular cAMP levels is an integral event in the modulation of anti-CD3-linked p59(fyn) activation in T cells. The experiments were carried out with splenic T cells from male Sprague-Dawley rats. A 30-50% suppression in the autophosphorylation and the kinase activity of p59(fyn) in T cells incubated with PGE(2) or forskolin was observed. Pretreatment of T cells with SQ-22536 prevented significant PGE(2)-mediated inhibition of T cell p59(fyn) kinase activity. In contrast, no change in p59(fyn) autophosphorylation and kinase activity in T cells treated with cAMP analogues was observed. These data suggest that PGE(2)-mediated suppression of p59(fyn) autophosphorylation and kinase activity in T cells is dependent on the activation of adenylate cyclase and independent of the elevation in cAMP levels." @default.
• W1844434462 created "2016-06-24" @default.
• W1844434462 creator A5034354453 @default.
• W1844434462 creator A5055975685 @default.
• W1844434462 creator A5084027124 @default.
• W1844434462 date "1999-08-01" @default.
• W1844434462 modified "2023-09-24" @default.
• W1844434462 title "PGE₂-mediated inhibition of T cell p59^fynis independent of cAMP" @default.
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• W1844434462 doi "https://doi.org/10.1152/ajpcell.1999.277.2.c302" @default.
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