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• W1844481612 endingPage "2343" @default.
• W1844481612 startingPage "2335" @default.
• W1844481612 abstract "Previous studies have shown that transforming growth factor alpha is expressed during rodent development. To establish the site(s) of transforming growth factor alpha mRNA expression during rat embryogensis, we performed in situ hybridization and Northern blot analyses on samples of embryonic and maternal tissues at various gestational ages. Our results indicate that the high levels of transforming growth factor alpha mRNA that are observed during early development are the result of expression in the maternal decidua and not in the embryo. Decidual expression appears to be induced after implantation, peaks at day 8, and then slowly declines through day 15 at which time the decidua is being resorbed. Expression of transforming growth factor alpha mRNA is highest in that region of the decidua adjacent to the embryo and is low or nondetectable in the uterus, placenta, and other maternal tissues. The developmentally regulated expression of transforming growth factor alpha mRNA in the decidua, together with the presence of epidermal growth factor receptors in this tissue, suggests that transforming growth factor alpha stimulates proliferation locally through an autocrine mechanism. Since epidermal growth factor receptors are present in the embryo and placenta, transforming growth factor alpha produced in the decidua may also act on these tissues through paracrine or endocrine mechanisms." @default.
• W1844481612 created "2016-06-24" @default.
• W1844481612 creator A5002371087 @default.
• W1844481612 creator A5057816070 @default.
• W1844481612 creator A5058882283 @default.
• W1844481612 creator A5070523775 @default.
• W1844481612 creator A5084907743 @default.
• W1844481612 date "1987-07-01" @default.
• W1844481612 modified "2023-10-18" @default.
• W1844481612 title "Expression of Rat Transforming Growth Factor Alpha mRNA during Development Occurs Predominantly in the Maternal Decidua" @default.
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• W1844481612 doi "https://doi.org/10.1128/mcb.7.7.2335-2343.1987" @default.
• W1844481612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/365364" @default.
• W1844481612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3475565" @default.
• W1844481612 hasPublicationYear "1987" @default.
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