Matches in SemOpenAlex for { <https://semopenalex.org/work/W1844484815> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1844484815 endingPage "271" @default.
- W1844484815 startingPage "264" @default.
- W1844484815 abstract "Acetaminophen and bromobenzene are transformed in the liver into chemically reactive metabolites that may either bind to glutathione and be detoxified or bind to hepatic proteins and produce liver cell necrosis. Fasting for 42 hr (a) decreased hepatic glutathione concentration, (b) increased the amount of chemically reactive metabolite irreversibly bound to hepatic proteins after administration of 3H-acetaminophen or 14C-bromobenzene, and (c) increased the hepatotoxicity of acetaminophen or bromobenzene. In rats fasted for various lengths of time, there was an inverse relationship between the concentration of glutathione in the liver and the activity of serum glutamic pyruvic transaminases after administration of acetaminophen or bromobenzene. In vitro, there was an inverse relationship between the concentration of glutathione in the incubate and the amount of chemically reactive metabolite bound to microsomal proteins after incubation of 3H-acetaminophen or 14C-bromobenzene with hepatic microsomes. It is concluded that fasting may decrease the inactivation of chemically reactive metabolites by glutathione, increase their binding to hepatic proteins, and enhance the hepatotoxicity of drugs transformed into chemically reactive metabolites that are detoxified by binding to glutathione." @default.
- W1844484815 created "2016-06-24" @default.
- W1844484815 creator A5021514439 @default.
- W1844484815 creator A5038743979 @default.
- W1844484815 creator A5043643675 @default.
- W1844484815 creator A5053420000 @default.
- W1844484815 creator A5062164901 @default.
- W1844484815 creator A5070090097 @default.
- W1844484815 creator A5080661113 @default.
- W1844484815 date "1979-08-01" @default.
- W1844484815 modified "2023-10-15" @default.
- W1844484815 title "Effect of fasting on metabolite-mediated hepatotoxicity in the rat" @default.
- W1844484815 cites W1492383398 @default.
- W1844484815 cites W1853819235 @default.
- W1844484815 cites W1989506902 @default.
- W1844484815 cites W2000387356 @default.
- W1844484815 cites W2005858995 @default.
- W1844484815 cites W2006370393 @default.
- W1844484815 cites W2018281025 @default.
- W1844484815 cites W2066113087 @default.
- W1844484815 cites W2069149674 @default.
- W1844484815 cites W2088771976 @default.
- W1844484815 cites W2174359461 @default.
- W1844484815 cites W2263023695 @default.
- W1844484815 cites W2319085435 @default.
- W1844484815 cites W4317648969 @default.
- W1844484815 doi "https://doi.org/10.1016/0016-5085(79)90275-0" @default.
- W1844484815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/109346" @default.
- W1844484815 hasPublicationYear "1979" @default.
- W1844484815 type Work @default.
- W1844484815 sameAs 1844484815 @default.
- W1844484815 citedByCount "119" @default.
- W1844484815 countsByYear W18444848152012 @default.
- W1844484815 countsByYear W18444848152014 @default.
- W1844484815 countsByYear W18444848152015 @default.
- W1844484815 countsByYear W18444848152016 @default.
- W1844484815 countsByYear W18444848152018 @default.
- W1844484815 countsByYear W18444848152019 @default.
- W1844484815 countsByYear W18444848152021 @default.
- W1844484815 countsByYear W18444848152022 @default.
- W1844484815 countsByYear W18444848152023 @default.
- W1844484815 crossrefType "journal-article" @default.
- W1844484815 hasAuthorship W1844484815A5021514439 @default.
- W1844484815 hasAuthorship W1844484815A5038743979 @default.
- W1844484815 hasAuthorship W1844484815A5043643675 @default.
- W1844484815 hasAuthorship W1844484815A5053420000 @default.
- W1844484815 hasAuthorship W1844484815A5062164901 @default.
- W1844484815 hasAuthorship W1844484815A5070090097 @default.
- W1844484815 hasAuthorship W1844484815A5080661113 @default.
- W1844484815 hasBestOaLocation W18444848151 @default.
- W1844484815 hasConcept C161790260 @default.
- W1844484815 hasConcept C181199279 @default.
- W1844484815 hasConcept C185592680 @default.
- W1844484815 hasConcept C202751555 @default.
- W1844484815 hasConcept C2776946247 @default.
- W1844484815 hasConcept C2777477808 @default.
- W1844484815 hasConcept C2778722691 @default.
- W1844484815 hasConcept C538909803 @default.
- W1844484815 hasConcept C55493867 @default.
- W1844484815 hasConcept C86803240 @default.
- W1844484815 hasConcept C87644729 @default.
- W1844484815 hasConcept C98274493 @default.
- W1844484815 hasConceptScore W1844484815C161790260 @default.
- W1844484815 hasConceptScore W1844484815C181199279 @default.
- W1844484815 hasConceptScore W1844484815C185592680 @default.
- W1844484815 hasConceptScore W1844484815C202751555 @default.
- W1844484815 hasConceptScore W1844484815C2776946247 @default.
- W1844484815 hasConceptScore W1844484815C2777477808 @default.
- W1844484815 hasConceptScore W1844484815C2778722691 @default.
- W1844484815 hasConceptScore W1844484815C538909803 @default.
- W1844484815 hasConceptScore W1844484815C55493867 @default.
- W1844484815 hasConceptScore W1844484815C86803240 @default.
- W1844484815 hasConceptScore W1844484815C87644729 @default.
- W1844484815 hasConceptScore W1844484815C98274493 @default.
- W1844484815 hasIssue "2" @default.
- W1844484815 hasLocation W18444848151 @default.
- W1844484815 hasLocation W18444848152 @default.
- W1844484815 hasOpenAccess W1844484815 @default.
- W1844484815 hasPrimaryLocation W18444848151 @default.
- W1844484815 hasRelatedWork W2003193738 @default.
- W1844484815 hasRelatedWork W2042554554 @default.
- W1844484815 hasRelatedWork W2053532436 @default.
- W1844484815 hasRelatedWork W2222772859 @default.
- W1844484815 hasRelatedWork W2261954172 @default.
- W1844484815 hasRelatedWork W2325130888 @default.
- W1844484815 hasRelatedWork W2393822538 @default.
- W1844484815 hasRelatedWork W2421628228 @default.
- W1844484815 hasRelatedWork W1969780327 @default.
- W1844484815 hasRelatedWork W2044231188 @default.
- W1844484815 hasVolume "77" @default.
- W1844484815 isParatext "false" @default.
- W1844484815 isRetracted "false" @default.
- W1844484815 magId "1844484815" @default.
- W1844484815 workType "article" @default.