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- W1844491432 abstract "Approximately 10% of the patients with small-cell lung cancer (SCLC) present with brain metastases at the time of diagnosis [1] and another 40% develop symptomatic CNS involvement during or after treatment [2]. At autopsy approximately 50% will have brain metastases [3], and the cumulative risk of developing brain metastases at two years’ survival is 50%–80% [2, 4]. The prognosis after a cerebral relapse is poor, with a median survival below three months [1, 5], whereas the isolated prognostic impact of CNS involvement at initial diagnosis is minimal [6]. A small fraction of patients will benefit from radiotherapy or chemotherapy and become long-term survivors despite their CNS involvement [7]." @default.
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- W1844491432 date "1995-11-01" @default.
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- W1844491432 title "Brain metastases in small-cell lung cancer" @default.
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- W1844491432 doi "https://doi.org/10.1093/oxfordjournals.annonc.a059363" @default.
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