FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1844690031> ?p ?o ?g. }

• W1844690031 endingPage "17569" @default.
• W1844690031 startingPage "17559" @default.
• W1844690031 abstract "// Zheng Li 1 , Xin Yu 1 , Yang Wang 2 , Jianxiong Shen 1 , William Ka Kei Wu 3 , Jinqian Liang 1 , Fan Feng 1 1 Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 2 Department of Abdominal Surgery, Cancer Institute and Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China 3 Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China Correspondence to: Jianxiong Shen, e-mail: shenjianxiong@medmail.com.cn Keywords: Gastric cancer, MicroRNAs, miR-329, TIAM1 Received: November 09, 2014      Accepted: November 16, 2014      Published: February 11, 2015 ABSTRACT Gastric cancer (GC) is one of the most common malignant tumors worldwide. Emerging evidence has shown that abnormal microRNAs (miRNAs) expression is involved in tumorigenesis. MiR-329 was previously reported to act as a tumor suppressor or oncogene in some types of cancer. However, its function in gastric cancer (GC) is unclear. Here, we found that miR-329 was down-regulated in GC compared with adjacent controls. Enforced expression of miR-329 inhibited proliferation, migration and invasion of gastric cancer cells in vitro . We identified T lymphoma invasion and metastasis 1 (TIAM1) gene as potential target of miR-329. MiR-329 levels inversely correlated with TIAM1 expression in GC. Importantly, TIAM1 rescued the miR-329-mediated inhibition of cell invasion and proliferation. Finally, reintroduction of miR-329 significantly inhibited tumor formation of GC in the xenograft mice. Our findings suggest that miR-329 is a tumor suppressor and potential therapeutic target of GC." @default.
• W1844690031 created "2016-06-24" @default.
• W1844690031 creator A5009085464 @default.
• W1844690031 creator A5056447268 @default.
• W1844690031 creator A5060335470 @default.
• W1844690031 creator A5067464528 @default.
• W1844690031 creator A5077387825 @default.
• W1844690031 creator A5086475800 @default.
• W1844690031 creator A5091607417 @default.
• W1844690031 date "2015-02-19" @default.
• W1844690031 modified "2023-10-12" @default.
• W1844690031 title "By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth" @default.
• W1844690031 cites W135309154 @default.
• W1844690031 cites W1502740750 @default.
• W1844690031 cites W1710176300 @default.
• W1844690031 cites W173881836 @default.
• W1844690031 cites W1829780875 @default.
• W1844690031 cites W1930806770 @default.
• W1844690031 cites W1969444967 @default.
• W1844690031 cites W1973329326 @default.
• W1844690031 cites W1976682721 @default.
• W1844690031 cites W1978086123 @default.
• W1844690031 cites W1985465557 @default.
• W1844690031 cites W1989143807 @default.
• W1844690031 cites W2003702497 @default.
• W1844690031 cites W2016171370 @default.
• W1844690031 cites W2021170096 @default.
• W1844690031 cites W2056203769 @default.
• W1844690031 cites W2068648285 @default.
• W1844690031 cites W2070800451 @default.
• W1844690031 cites W2071056055 @default.
• W1844690031 cites W2079076968 @default.
• W1844690031 cites W2079126151 @default.
• W1844690031 cites W2097494801 @default.
• W1844690031 cites W2103824791 @default.
• W1844690031 cites W2104857427 @default.
• W1844690031 cites W2108598050 @default.
• W1844690031 cites W2114216915 @default.
• W1844690031 cites W2119569102 @default.
• W1844690031 cites W2125526025 @default.
• W1844690031 cites W2128796736 @default.
• W1844690031 cites W2131811102 @default.
• W1844690031 cites W2141643004 @default.
• W1844690031 cites W2143939772 @default.
• W1844690031 cites W2148108295 @default.
• W1844690031 cites W2149699310 @default.
• W1844690031 cites W2150556769 @default.
• W1844690031 cites W2153096597 @default.
• W1844690031 cites W2158680377 @default.
• W1844690031 cites W2159940325 @default.
• W1844690031 cites W2162916578 @default.
• W1844690031 cites W2168314151 @default.
• W1844690031 cites W2252647763 @default.
• W1844690031 cites W2317361272 @default.
• W1844690031 cites W2335347980 @default.
• W1844690031 cites W4246970052 @default.
• W1844690031 cites W61602495 @default.
• W1844690031 doi "https://doi.org/10.18632/oncotarget.2755" @default.
• W1844690031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4627328" @default.
• W1844690031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25654811" @default.
• W1844690031 hasPublicationYear "2015" @default.
• W1844690031 type Work @default.
• W1844690031 sameAs 1844690031 @default.
• W1844690031 citedByCount "103" @default.
• W1844690031 countsByYear W18446900312015 @default.
• W1844690031 countsByYear W18446900312016 @default.
• W1844690031 countsByYear W18446900312017 @default.
• W1844690031 countsByYear W18446900312018 @default.
• W1844690031 countsByYear W18446900312019 @default.
• W1844690031 countsByYear W18446900312020 @default.
• W1844690031 countsByYear W18446900312022 @default.
• W1844690031 countsByYear W18446900312023 @default.
• W1844690031 crossrefType "journal-article" @default.
• W1844690031 hasAuthorship W1844690031A5009085464 @default.
• W1844690031 hasAuthorship W1844690031A5056447268 @default.
• W1844690031 hasAuthorship W1844690031A5060335470 @default.
• W1844690031 hasAuthorship W1844690031A5067464528 @default.
• W1844690031 hasAuthorship W1844690031A5077387825 @default.
• W1844690031 hasAuthorship W1844690031A5086475800 @default.
• W1844690031 hasAuthorship W1844690031A5091607417 @default.
• W1844690031 hasBestOaLocation W18446900311 @default.
• W1844690031 hasConcept C104317684 @default.
• W1844690031 hasConcept C121608353 @default.
• W1844690031 hasConcept C126322002 @default.
• W1844690031 hasConcept C143998085 @default.
• W1844690031 hasConcept C145059251 @default.
• W1844690031 hasConcept C2779013556 @default.
• W1844690031 hasConcept C2781018059 @default.
• W1844690031 hasConcept C29537977 @default.
• W1844690031 hasConcept C502942594 @default.
• W1844690031 hasConcept C54355233 @default.
• W1844690031 hasConcept C555283112 @default.
• W1844690031 hasConcept C71924100 @default.
• W1844690031 hasConcept C86803240 @default.
• W1844690031 hasConcept C96232424 @default.
• W1844690031 hasConceptScore W1844690031C104317684 @default.
• W1844690031 hasConceptScore W1844690031C121608353 @default.
• W1844690031 hasConceptScore W1844690031C126322002 @default.

• next