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• W184469694 abstract "Introduction: Women are less likely to develop colon cancer than men. This has been attributed to a protective effect of estrogen, which may be transmitted through the estrogen receptor β (ERβ). A reduced expression of ERβ in the tumor has been observed in patients with colorectal cancer. However, it is unclear whether sex differences in the level of ERβ expression in tumors exist. Furthermore, little is known about the relationship between ERβ expression and tumor stage. Therefore, the expression of ERβ in various stages of colon cancer was studied in male and female patients. Methods: Using Western blot analysis, the expression of ERβ in normal colon tissue and in tumor tissue was analyzed in 68 patients with colorectal cancer (37 males, mean age 64.2 ± 12.9 years, and 31 females, mean age 68.5 ± 14.5 years). Tissue samples were obtained from resected specimens and were snap frozen in liquid nitrogen until further analysis. The relative expression of ERβ protein in the tumor compared to the expression in normal colon tissue of the same patient was determined. The level of ERβ expression was compared between genders, tumor stages and tumor differentiation. Results: All patients displayed ERβ protein expression in normal colon mucosa. There was no difference between male and female patients. A reduced level of ERβ expression was observed in 91% (n = 61) of all patients. This was more pronounced in male than in female patients. In men, the ERβ expression in the tumor was 52.7% of the expression in normal tissue, whereas in women, the ERβ expression in tumor tissue reached 72.3%. Tumor progression and tumor dedifferentiation were also associated with decreasing levels of ERβ protein expression. In T2 tumors the ERβ expression was 67.9% of the expression in normal tissue, whereas in T4 tumors the ERβ expression decreased to 45.4%. Moderately differentiated (G2) tumors displayed mean ERβ protein expression levels of 68.3% whereas in poorly differentiated (G3) tumors the ERβ protein expression decreased to 56.6%. However, due to highly variable individual levels, statistic significance was only reached among male patients (p < 0.05). In these patients ERβ protein levels were 61.0% in G2 tumors and 40.5% in G3 tumors. Conclusion: This study provides evidence for reduced ERβ protein expression in the colon in patients with colorectal cancer. This reduction of ERβ expression was more pronounced in men than in women. Furthermore, advanced tumor stages and poor differentiation of the tumor were also associated with decreased levels of ERβ protein expression. These observations support the hypothesis of a protective ERβ mediated effect of estrogen against malignant transformation in the gastrointestinal tract." @default.
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• W184469694 date "2005-01-01" @default.
• W184469694 modified "2023-09-27" @default.
• W184469694 title "Die Expression des Östrogenrezeptors beta (ERβ) bei Colonkarzinom ist bei Männern und niedrig differenzierten Tumoren stärker vermindert als bei Frauen und hoch differenzierten Tumoren" @default.
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• W184469694 doi "https://doi.org/10.1007/3-540-26560-0_33" @default.
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