FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1844798933> ?p ?o ?g. }

• W1844798933 endingPage "6069" @default.
• W1844798933 startingPage "6061" @default.
• W1844798933 abstract "The outcome of mouse CMV (MCMV) infection varies among different inbred mouse strains depending on NK cell effector functions governed through recognition receptor triggering. NK cells from different mouse strains possess diverse repertoires of activating or inhibitory Ly49 receptors, which share some of their polymorphic MHC class I (MHC-I) ligands. By examining the NK cell response to MCMV infection in novel BALB substrains congenic for different MHC (or H-2 in mice) haplotypes, we show that recognition of viral MHC-I-like protein m157 by inhibitory Ly49C receptor allows escape from NK cell control of viral replication. Dominant inhibition by Ly49C bound to self-H-2(b) encoded MHC-I molecules masks this effect, which only becomes apparent in distinct H-2 haplotypes, such as H-2(f). The recognition of m157-expressing cells by Ly49C resulted in both decreased NK cell killing in vitro and reduced rejection in vivo. Further, control of infection with m157-deletant (Δm157) MCMV was improved in mice carrying H-2 molecules unrecognized by Ly49C but allowing expansion of NK cell effectors expressing activating Ly49L receptors. Hence, our study is the first, to our knowledge, to demonstrate that MHC-I mimicry strategies used by MCMV to avoid NK cell control are biologically relevant during in vivo viral infection. Of value for human studies is that only a few genetic assortments conditional on the repertoires of viral MHC-I-like proteins/host NK receptors/MHC haplotypes should allow efficient protection against CMV infection." @default.
• W1844798933 created "2016-06-24" @default.
• W1844798933 creator A5014245073 @default.
• W1844798933 creator A5021307048 @default.
• W1844798933 creator A5026168352 @default.
• W1844798933 creator A5038051461 @default.
• W1844798933 creator A5049725885 @default.
• W1844798933 creator A5058671714 @default.
• W1844798933 date "2014-12-15" @default.
• W1844798933 modified "2023-09-27" @default.
• W1844798933 title "Viral MHC Class I–like Molecule Allows Evasion of NK Cell Effector Responses In Vivo" @default.
• W1844798933 cites W1500247462 @default.
• W1844798933 cites W1520347430 @default.
• W1844798933 cites W1573815488 @default.
• W1844798933 cites W1633996651 @default.
• W1844798933 cites W1926148351 @default.
• W1844798933 cites W1966280572 @default.
• W1844798933 cites W1968028452 @default.
• W1844798933 cites W1969950463 @default.
• W1844798933 cites W1970780198 @default.
• W1844798933 cites W1982452175 @default.
• W1844798933 cites W1990592512 @default.
• W1844798933 cites W1994872698 @default.
• W1844798933 cites W1994888826 @default.
• W1844798933 cites W1999092913 @default.
• W1844798933 cites W2004822121 @default.
• W1844798933 cites W2006233454 @default.
• W1844798933 cites W2011017810 @default.
• W1844798933 cites W2016208474 @default.
• W1844798933 cites W2020750867 @default.
• W1844798933 cites W2023502808 @default.
• W1844798933 cites W2031134093 @default.
• W1844798933 cites W2032041382 @default.
• W1844798933 cites W2038034255 @default.
• W1844798933 cites W2040242408 @default.
• W1844798933 cites W2041919004 @default.
• W1844798933 cites W2043570079 @default.
• W1844798933 cites W2049288134 @default.
• W1844798933 cites W2064890413 @default.
• W1844798933 cites W2066215633 @default.
• W1844798933 cites W2077941514 @default.
• W1844798933 cites W2083592738 @default.
• W1844798933 cites W2091055845 @default.
• W1844798933 cites W2095498551 @default.
• W1844798933 cites W2095548329 @default.
• W1844798933 cites W2104430719 @default.
• W1844798933 cites W2110988104 @default.
• W1844798933 cites W2116407096 @default.
• W1844798933 cites W2118376550 @default.
• W1844798933 cites W2119809419 @default.
• W1844798933 cites W2125128634 @default.
• W1844798933 cites W2134438797 @default.
• W1844798933 cites W2135793489 @default.
• W1844798933 cites W2137675187 @default.
• W1844798933 cites W2140640732 @default.
• W1844798933 cites W2143244825 @default.
• W1844798933 cites W2143599482 @default.
• W1844798933 cites W2146261880 @default.
• W1844798933 cites W2165232639 @default.
• W1844798933 cites W2166461166 @default.
• W1844798933 cites W2166807496 @default.
• W1844798933 doi "https://doi.org/10.4049/jimmunol.1401386" @default.
• W1844798933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25392524" @default.
• W1844798933 hasPublicationYear "2014" @default.
• W1844798933 type Work @default.
• W1844798933 sameAs 1844798933 @default.
• W1844798933 citedByCount "18" @default.
• W1844798933 countsByYear W18447989332015 @default.
• W1844798933 countsByYear W18447989332016 @default.
• W1844798933 countsByYear W18447989332017 @default.
• W1844798933 countsByYear W18447989332018 @default.
• W1844798933 countsByYear W18447989332019 @default.
• W1844798933 countsByYear W18447989332020 @default.
• W1844798933 countsByYear W18447989332021 @default.
• W1844798933 countsByYear W18447989332023 @default.
• W1844798933 crossrefType "journal-article" @default.
• W1844798933 hasAuthorship W1844798933A5014245073 @default.
• W1844798933 hasAuthorship W1844798933A5021307048 @default.
• W1844798933 hasAuthorship W1844798933A5026168352 @default.
• W1844798933 hasAuthorship W1844798933A5038051461 @default.
• W1844798933 hasAuthorship W1844798933A5049725885 @default.
• W1844798933 hasAuthorship W1844798933A5058671714 @default.
• W1844798933 hasBestOaLocation W18447989331 @default.
• W1844798933 hasConcept C147483822 @default.
• W1844798933 hasConcept C159047783 @default.
• W1844798933 hasConcept C170493617 @default.
• W1844798933 hasConcept C170627219 @default.
• W1844798933 hasConcept C203014093 @default.
• W1844798933 hasConcept C207936829 @default.
• W1844798933 hasConcept C51785407 @default.
• W1844798933 hasConcept C54355233 @default.
• W1844798933 hasConcept C86803240 @default.
• W1844798933 hasConcept C95444343 @default.
• W1844798933 hasConceptScore W1844798933C147483822 @default.
• W1844798933 hasConceptScore W1844798933C159047783 @default.
• W1844798933 hasConceptScore W1844798933C170493617 @default.
• W1844798933 hasConceptScore W1844798933C170627219 @default.
• W1844798933 hasConceptScore W1844798933C203014093 @default.

• next