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• W1844852786 startingPage "4398" @default.
• W1844852786 abstract "Mice with a targeted deletion of the low-affinity neurotrophin receptor p75 (p75-/-) exhibit a 50% loss of large- and small-diameter sensory neurons in the dorsal root ganglion. Using neurophysiological recording techniques, we now show that p75 is not required for the survival of specific, functionally defined subpopulations of sensory neurons. Rather, p75-/- mice exhibit losses of neurons that subserve nociceptive as well as non-nociceptive functions. The receptive properties of large myelinated afferent fibers were normal in p75-/- mice. However, the receptive properties of subpopulations of afferent fibers with thin myelinated or unmyelinated axons were strikingly impaired in mice lacking p75. Furthermore, the presence of p75 is required for normal mechanotransduction in C fibers and D-hair receptors and normal heat sensitivity in A-fiber nociceptors." @default.
• W1844852786 created "2016-06-24" @default.
• W1844852786 creator A5072856043 @default.
• W1844852786 creator A5088325043 @default.
• W1844852786 date "1997-06-01" @default.
• W1844852786 modified "2023-10-13" @default.
• W1844852786 title "The Low-Affinity Neurotrophin Receptor p75 Regulates the Function But Not the Selective Survival of Specific Subpopulations of Sensory Neurons" @default.
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• W1844852786 doi "https://doi.org/10.1523/jneurosci.17-11-04398.1997" @default.
• W1844852786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6573523" @default.
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