FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1844973750> ?p ?o ?g. }

• W1844973750 endingPage "1447" @default.
• W1844973750 startingPage "1441" @default.
• W1844973750 abstract "Introduction Dystonia is frequent in Machado–Joseph disease, but several important aspects are not yet defined, such as the detailed clinical profile, response to treatment and anatomical substrate. Methods We screened 75 consecutive patients and identified those with dystonia. The Burke-Marsden-Fahn Dystonia Rating Scale was employed to quantify dystonia severity. Patients with dystonia received levodopa 600 mg/day for 2 months and were videotaped before and after treatment. A blinded evaluator rated dystonia in the videos. Patients with disabling dystonia who failed to respond to levodopa treatment received botulinum toxin. Finally, volumetric T1 and diffusion tensor imaging sequences were obtained in the dystonic group using a 3T-MRI scanner to identify areas of gray and white matter that were selectively damaged. Results There were 21 patients with dystonia (28%): 9 classified as generalized and 12 as focal/segmental. Patients with dystonia had earlier onset and larger (CAG) expansions (28.9 ± 11.7 vs 40.6 ± 11.4; p < 0.001 and 75 vs 70; p < 0.001, respectively). Although group analyses failed to show benefit on levodopa (p = 0.07), some patients had objective improvement. In addition, ten patients received botulinum toxin resulting in a significant change in dystonia scores after 4 weeks (p = 0.03). Patients with dystonia had atrophy at pre- and paracentral cortices; whereas, non-dystonic patients had occipital atrophy. Basal ganglia volume was reduced in both groups, but atrophy at the thalami, cerebellar white matter and ventral diencephali was disproportionately higher in the dystonic group. Conclusion Dystonia in Machado–Joseph disease is frequent and often disabling, but may respond to levodopa. It is associated predominantly with structural abnormalities around the motor cortices and in the thalami." @default.
• W1844973750 created "2016-06-24" @default.
• W1844973750 creator A5002307072 @default.
• W1844973750 creator A5010357939 @default.
• W1844973750 creator A5020192663 @default.
• W1844973750 creator A5022553846 @default.
• W1844973750 creator A5026417703 @default.
• W1844973750 creator A5043180090 @default.
• W1844973750 creator A5059187961 @default.
• W1844973750 date "2015-12-01" @default.
• W1844973750 modified "2023-09-30" @default.
• W1844973750 title "Dystonia in Machado–Joseph disease: Clinical profile, therapy and anatomical basis" @default.
• W1844973750 cites W1571587926 @default.
• W1844973750 cites W1967521249 @default.
• W1844973750 cites W1982390702 @default.
• W1844973750 cites W1985316716 @default.
• W1844973750 cites W1989314441 @default.
• W1844973750 cites W1994303356 @default.
• W1844973750 cites W2007803771 @default.
• W1844973750 cites W2008150570 @default.
• W1844973750 cites W2018425001 @default.
• W1844973750 cites W2023105110 @default.
• W1844973750 cites W2030715798 @default.
• W1844973750 cites W2040073664 @default.
• W1844973750 cites W2048764127 @default.
• W1844973750 cites W2049295385 @default.
• W1844973750 cites W2073012734 @default.
• W1844973750 cites W2079526757 @default.
• W1844973750 cites W2085240659 @default.
• W1844973750 cites W2090598967 @default.
• W1844973750 cites W2091832822 @default.
• W1844973750 cites W2100093562 @default.
• W1844973750 cites W2101135654 @default.
• W1844973750 cites W2103719228 @default.
• W1844973750 cites W2108129644 @default.
• W1844973750 cites W2112268040 @default.
• W1844973750 cites W2131134103 @default.
• W1844973750 cites W2150667092 @default.
• W1844973750 cites W2160927505 @default.
• W1844973750 cites W4237519055 @default.
• W1844973750 cites W4241074797 @default.
• W1844973750 doi "https://doi.org/10.1016/j.parkreldis.2015.10.016" @default.
• W1844973750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26552869" @default.
• W1844973750 hasPublicationYear "2015" @default.
• W1844973750 type Work @default.
• W1844973750 sameAs 1844973750 @default.
• W1844973750 citedByCount "26" @default.
• W1844973750 countsByYear W18449737502017 @default.
• W1844973750 countsByYear W18449737502018 @default.
• W1844973750 countsByYear W18449737502019 @default.
• W1844973750 countsByYear W18449737502020 @default.
• W1844973750 countsByYear W18449737502021 @default.
• W1844973750 countsByYear W18449737502022 @default.
• W1844973750 countsByYear W18449737502023 @default.
• W1844973750 crossrefType "journal-article" @default.
• W1844973750 hasAuthorship W1844973750A5002307072 @default.
• W1844973750 hasAuthorship W1844973750A5010357939 @default.
• W1844973750 hasAuthorship W1844973750A5020192663 @default.
• W1844973750 hasAuthorship W1844973750A5022553846 @default.
• W1844973750 hasAuthorship W1844973750A5026417703 @default.
• W1844973750 hasAuthorship W1844973750A5043180090 @default.
• W1844973750 hasAuthorship W1844973750A5059187961 @default.
• W1844973750 hasConcept C126322002 @default.
• W1844973750 hasConcept C126838900 @default.
• W1844973750 hasConcept C143409427 @default.
• W1844973750 hasConcept C15744967 @default.
• W1844973750 hasConcept C169760540 @default.
• W1844973750 hasConcept C2777478456 @default.
• W1844973750 hasConcept C2777641544 @default.
• W1844973750 hasConcept C2778187257 @default.
• W1844973750 hasConcept C2778542668 @default.
• W1844973750 hasConcept C2778559928 @default.
• W1844973750 hasConcept C2778817116 @default.
• W1844973750 hasConcept C2779134260 @default.
• W1844973750 hasConcept C2779494072 @default.
• W1844973750 hasConcept C2779734285 @default.
• W1844973750 hasConcept C2780304432 @default.
• W1844973750 hasConcept C2781172350 @default.
• W1844973750 hasConcept C2781192897 @default.
• W1844973750 hasConcept C42219234 @default.
• W1844973750 hasConcept C529278444 @default.
• W1844973750 hasConcept C71924100 @default.
• W1844973750 hasConceptScore W1844973750C126322002 @default.
• W1844973750 hasConceptScore W1844973750C126838900 @default.
• W1844973750 hasConceptScore W1844973750C143409427 @default.
• W1844973750 hasConceptScore W1844973750C15744967 @default.
• W1844973750 hasConceptScore W1844973750C169760540 @default.
• W1844973750 hasConceptScore W1844973750C2777478456 @default.
• W1844973750 hasConceptScore W1844973750C2777641544 @default.
• W1844973750 hasConceptScore W1844973750C2778187257 @default.
• W1844973750 hasConceptScore W1844973750C2778542668 @default.
• W1844973750 hasConceptScore W1844973750C2778559928 @default.
• W1844973750 hasConceptScore W1844973750C2778817116 @default.
• W1844973750 hasConceptScore W1844973750C2779134260 @default.
• W1844973750 hasConceptScore W1844973750C2779494072 @default.
• W1844973750 hasConceptScore W1844973750C2779734285 @default.
• W1844973750 hasConceptScore W1844973750C2780304432 @default.
• W1844973750 hasConceptScore W1844973750C2781172350 @default.

• next