Matches in SemOpenAlex for { <https://semopenalex.org/work/W1844990943> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1844990943 endingPage "162" @default.
- W1844990943 startingPage "153" @default.
- W1844990943 abstract "To investigate the role of CD40 ligand in the delivery of help to B cells, we examined the Ag-specific interaction of B cells from CD40-deficient mice with a Th2 cell line in vitro. Small resting B cells from normal mice are stimulated to synthesize DNA when they present monovalent Ag (rabbit Fab anti-Ig) to a rabbit Ig-specific Th cell line. This response, which is independent of a signal through the B cell Ag receptor (sIg), is nearly absent in B cells from CD40-deficient mice. The CD40-deficient B cells are not defective in Ag presentation because they induce T cell IL-4 synthesis as well as normal B cells. Also, CD40-deficient B cells respond to T cell help with DNA synthesis almost as well as normal B cells if an additional signal is provided through sIg. In conjunction with a sIg signal, cell contact with helper T cells induces DNA synthesis more effectively than soluble cytokines. CD40-independent T cell help can also be measured as an early increase in c-myc mRNA levels in CD40-deficient B cells presenting Ag to helper T cells, although the levels of c-myc RNA expression are lower than those in normal B cells. However, c-myc RNA induced by noncognate interaction with anti-CD3-activated T cells is completely CD40 dependent. We conclude that early growth signals from activated Th cells are received by CD40-/- B cells, but that CD40 and/or sIg signals are required for efficient induction of DNA synthesis." @default.
- W1844990943 created "2016-06-24" @default.
- W1844990943 creator A5000277715 @default.
- W1844990943 creator A5026011921 @default.
- W1844990943 creator A5058270087 @default.
- W1844990943 creator A5087748905 @default.
- W1844990943 date "1997-01-01" @default.
- W1844990943 modified "2023-10-17" @default.
- W1844990943 title "Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig." @default.
- W1844990943 doi "https://doi.org/10.4049/jimmunol.158.1.153" @default.
- W1844990943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8977186" @default.
- W1844990943 hasPublicationYear "1997" @default.
- W1844990943 type Work @default.
- W1844990943 sameAs 1844990943 @default.
- W1844990943 citedByCount "6" @default.
- W1844990943 crossrefType "journal-article" @default.
- W1844990943 hasAuthorship W1844990943A5000277715 @default.
- W1844990943 hasAuthorship W1844990943A5026011921 @default.
- W1844990943 hasAuthorship W1844990943A5058270087 @default.
- W1844990943 hasAuthorship W1844990943A5087748905 @default.
- W1844990943 hasConcept C145558887 @default.
- W1844990943 hasConcept C1491633281 @default.
- W1844990943 hasConcept C153911025 @default.
- W1844990943 hasConcept C154317977 @default.
- W1844990943 hasConcept C159654299 @default.
- W1844990943 hasConcept C200180986 @default.
- W1844990943 hasConcept C202751555 @default.
- W1844990943 hasConcept C203014093 @default.
- W1844990943 hasConcept C2776090121 @default.
- W1844990943 hasConcept C2778453870 @default.
- W1844990943 hasConcept C39347974 @default.
- W1844990943 hasConcept C54355233 @default.
- W1844990943 hasConcept C552990157 @default.
- W1844990943 hasConcept C55493867 @default.
- W1844990943 hasConcept C64241487 @default.
- W1844990943 hasConcept C67662055 @default.
- W1844990943 hasConcept C81885089 @default.
- W1844990943 hasConcept C86803240 @default.
- W1844990943 hasConcept C8891405 @default.
- W1844990943 hasConcept C95444343 @default.
- W1844990943 hasConceptScore W1844990943C145558887 @default.
- W1844990943 hasConceptScore W1844990943C1491633281 @default.
- W1844990943 hasConceptScore W1844990943C153911025 @default.
- W1844990943 hasConceptScore W1844990943C154317977 @default.
- W1844990943 hasConceptScore W1844990943C159654299 @default.
- W1844990943 hasConceptScore W1844990943C200180986 @default.
- W1844990943 hasConceptScore W1844990943C202751555 @default.
- W1844990943 hasConceptScore W1844990943C203014093 @default.
- W1844990943 hasConceptScore W1844990943C2776090121 @default.
- W1844990943 hasConceptScore W1844990943C2778453870 @default.
- W1844990943 hasConceptScore W1844990943C39347974 @default.
- W1844990943 hasConceptScore W1844990943C54355233 @default.
- W1844990943 hasConceptScore W1844990943C552990157 @default.
- W1844990943 hasConceptScore W1844990943C55493867 @default.
- W1844990943 hasConceptScore W1844990943C64241487 @default.
- W1844990943 hasConceptScore W1844990943C67662055 @default.
- W1844990943 hasConceptScore W1844990943C81885089 @default.
- W1844990943 hasConceptScore W1844990943C86803240 @default.
- W1844990943 hasConceptScore W1844990943C8891405 @default.
- W1844990943 hasConceptScore W1844990943C95444343 @default.
- W1844990943 hasIssue "1" @default.
- W1844990943 hasLocation W18449909431 @default.
- W1844990943 hasLocation W18449909432 @default.
- W1844990943 hasOpenAccess W1844990943 @default.
- W1844990943 hasPrimaryLocation W18449909431 @default.
- W1844990943 hasRelatedWork W1161275149 @default.
- W1844990943 hasRelatedWork W1494583649 @default.
- W1844990943 hasRelatedWork W1521069964 @default.
- W1844990943 hasRelatedWork W1857920654 @default.
- W1844990943 hasRelatedWork W1903855848 @default.
- W1844990943 hasRelatedWork W1980061078 @default.
- W1844990943 hasRelatedWork W2134564419 @default.
- W1844990943 hasRelatedWork W2538149674 @default.
- W1844990943 hasRelatedWork W4313356390 @default.
- W1844990943 hasRelatedWork W832929248 @default.
- W1844990943 hasVolume "158" @default.
- W1844990943 isParatext "false" @default.
- W1844990943 isRetracted "false" @default.
- W1844990943 magId "1844990943" @default.
- W1844990943 workType "article" @default.