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• W1844998737 abstract "Possible adaptive mechanisms that may defend against weight gain during periods of excessive energy intake were investigated by overfeeding six lean and three overweight young men by 50% above baseline requirements with a mixed diet for 42 d [6.2 ± 1.9 MJ/d (x̄ ± SD), or a total of 265 ± 45 MJ]. Mean weight gain was 7.6 ± 1.6 kg (58 ± 18% fat). The energy cost of tissue deposition (28.7 ± 4.4 MJ/kg) matched the theoretical cost (26.0 MJ/kg). Basal metabolic rate (BMR) increased by 0.9 ± 0.4 MJ/d and daily energy expenditure assessed by whole-body calorimetry (CAL EE) increased by 1.8 ± 0.5 MJ/d. Total free-living energy expenditure (TEE) measured by doubly labeled water increased by 1.4 ± 2.0 MJ/d. Activity and thermogenesis (computed as CAL EE — BMR and TEE — BMR) increased by only 0.9 ± 0.4 and 0.9 ± 2.1 MJ/d, respectively. All outcomes were consistent with theoretical changes due to the increased fat-free mass, body weight, and energy intake. There was no evidence of any active energy-dissipating mechanisms." @default.
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• W1844998737 date "1992-10-01" @default.
• W1844998737 modified "2023-10-18" @default.
• W1844998737 title "Metabolic response to experimental overfeeding in lean and overweight healthy volunteers" @default.
• W1844998737 doi "https://doi.org/10.1093/ajcn/56.4.641" @default.
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