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- W1845220076 abstract "The Bacillus subtilis sigW gene encodes an extracytoplasmic function (ECF) sigma factor that is expressed in early stationary phase from a sigW-dependent autoregulatory promoter, PW. Using a consensus-based search procedure, we have identified 15 operons preceded by promoters similar in sequence to PW. At least 14 of these promoters are dependent on sigma W both in vivo and in vitro as judged by lacZ reporter fusions, run-off transcription assays and nucleotide resolution start site mapping. We conclude that sigma W controls a regulon of more than 30 genes, many of which encode membrane proteins of unknown function. The sigma W regulon includes a penicillin binding protein (PBP4*) and a co-transcribed amino acid racemase (RacX), homologues of signal peptide peptidase (YteI), flotillin (YuaG), ABC transporters (YknXYZ), non-haem bromoperoxidase (YdjP), epoxide hydrolase (YfhM) and three small peptides with structural similarities to bacteriocin precursor polypeptides. We suggest that sigma W activates a large stationary-phase regulon that functions in detoxification, production of anti-microbial compounds or both." @default.
- W1845220076 created "2016-06-24" @default.
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- W1845220076 date "1999-01-01" @default.
- W1845220076 modified "2023-10-07" @default.
- W1845220076 title "Identification of target promoters for the Bacillus subtilis extracytoplasmic function sigma factor, sigmaW" @default.
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- W1845220076 doi "https://doi.org/10.1046/j.1365-2958.1999.01180.x" @default.
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