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- W1845320669 abstract "Intact rats and rats with hysterectomies and/or ovariectomies were given daily doses (0.1–10 μg per kilogram per day) of ethinyl estradiol (EE) for 7 days by the subcutaneous route. Body weights were determined before administration and on the afternoon of the day of the seventh dose. Several blood coagulation test systems (partial thromboplastin time, thrombelastography, whole blood clotting time, antithrombin concentration, fibrinolysis potential, and fibrinogen concentrations) were studied on the eighth day when the rats were killed. The uterus (if present) was weighed. The results indicate that ovariectomy increased the effect of EE on lowering antithrombin activity and on lowering body weight gain in comparison to the effect of EE in intact rats or rats with hysterectomies. There was no effect on whole blood clotting time, thrombelastography, or partial thromboplastin time. The greatest and most significant changes were a dose-related loss in body weight and lowered antithrombin activity in the ovariectomized rat given 1, 3, 10 μg of EE per kilogram per day. The use of the ovariectomized rat as an animal model for testing the effect of different gonadal hormones on blood coagulation factors is suggested." @default.
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- W1845320669 date "1974-04-01" @default.
- W1845320669 modified "2023-09-26" @default.
- W1845320669 title "The effect on blood coagulation of ovariectomy and hysterectomy in rats given ethinyl estradiol" @default.
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- W1845320669 doi "https://doi.org/10.1016/0002-9378(74)90680-2" @default.
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