Matches in SemOpenAlex for { <https://semopenalex.org/work/W184534903> ?p ?o ?g. }
- W184534903 endingPage "39" @default.
- W184534903 startingPage "721" @default.
- W184534903 abstract "The noradrenergic (NA-ergic) rapid eye movement (REM)-OFF neurons in locus coeruleus (LC) and cholinergic REM-ON neurons in laterodorsal/pedunculopontine tegmentum show a reciprocal firing pattern. The REM-ON neurons fire during REM sleep whereas REM-OFF neurons stop firing during REM sleep. The cessation of firing of REM-OFF neurons is a pre-requisite for the generation of REM sleep and non-cessation of those neurons result in REM sleep loss that is characterized by symptoms like loss of memory retention, irritation, hypersexuality, etc. There is an intricate interplay between the REM-OFF and REM-ON neurons for REM sleep regulation. Acetylcholine from REM-ON neurons excites the GABA-ergic interneurons in the LC that in turn inhibit the REM-OFF neurons. The cessation of firing of REM-OFF neurons withdraws the inhibition from the REM-ON neurons, and facilitates the excitation of these neurons resulting in the initiation of REM sleep. GABA modulates the generation of REM sleep in pedunculopontine tegmentum (PPT) by acting pre-synaptically on the NA-ergic terminals that synapse on the REM-ON neurons whereas in LC it modulates the maintenance of REM sleep by acting post-synaptically on REM-OFF neurons. The activity of REM sleep related neurons is modulated by wakefulness (midbrain reticular formation/ascending reticular activating system) and sleep inducing (caudal brainstem/medullary reticular formation) areas. Thus, during wakefulness the wake-active neurons keep on firing that excites the REM-OFF neurons, which in turn keeps the REMON neurons inhibited; therefore, during wakefulness REM sleep episodes are not expressed. Additionally, the wakefulness inducing area keeps the REM-ON neurons inhibited. In contrast, the sleep inducing area excites the REM-ON neurons. Thus, the wakefulness inducing area excites and inhibits the REM-OFF and REM-ON neurons, respectively, while the sleep inducing area excites the REM-ON neurons that facilitate the generation of REM sleep." @default.
- W184534903 created "2016-06-24" @default.
- W184534903 creator A5062211145 @default.
- W184534903 creator A5062609491 @default.
- W184534903 date "2007-06-01" @default.
- W184534903 modified "2023-09-23" @default.
- W184534903 title "Neural mechanism of rapid eye movement sleep generation with reference to REM-OFF neurons in locus coeruleus." @default.
- W184534903 cites W108465920 @default.
- W184534903 cites W13109001 @default.
- W184534903 cites W14420045 @default.
- W184534903 cites W1490402531 @default.
- W184534903 cites W151282802 @default.
- W184534903 cites W1513595583 @default.
- W184534903 cites W1521227715 @default.
- W184534903 cites W1524442275 @default.
- W184534903 cites W1564731682 @default.
- W184534903 cites W1568822448 @default.
- W184534903 cites W1577656838 @default.
- W184534903 cites W1580861088 @default.
- W184534903 cites W1588053646 @default.
- W184534903 cites W1589759057 @default.
- W184534903 cites W1601087798 @default.
- W184534903 cites W1605774457 @default.
- W184534903 cites W1633465816 @default.
- W184534903 cites W1725059567 @default.
- W184534903 cites W1761768872 @default.
- W184534903 cites W1839013370 @default.
- W184534903 cites W1852650488 @default.
- W184534903 cites W1857655985 @default.
- W184534903 cites W1881374729 @default.
- W184534903 cites W190151615 @default.
- W184534903 cites W1963772961 @default.
- W184534903 cites W1964893911 @default.
- W184534903 cites W1965251217 @default.
- W184534903 cites W1967285334 @default.
- W184534903 cites W1967797215 @default.
- W184534903 cites W1968070351 @default.
- W184534903 cites W1972590866 @default.
- W184534903 cites W1972877686 @default.
- W184534903 cites W1974908385 @default.
- W184534903 cites W1975476104 @default.
- W184534903 cites W1979302847 @default.
- W184534903 cites W1979355251 @default.
- W184534903 cites W1981388992 @default.
- W184534903 cites W1982283077 @default.
- W184534903 cites W1983003665 @default.
- W184534903 cites W1983643022 @default.
- W184534903 cites W1984135601 @default.
- W184534903 cites W1985464433 @default.
- W184534903 cites W1985496076 @default.
- W184534903 cites W1985500707 @default.
- W184534903 cites W1985575945 @default.
- W184534903 cites W1986919226 @default.
- W184534903 cites W1987014196 @default.
- W184534903 cites W1987514581 @default.
- W184534903 cites W1987550857 @default.
- W184534903 cites W1989212737 @default.
- W184534903 cites W1993259981 @default.
- W184534903 cites W1993378726 @default.
- W184534903 cites W1993919250 @default.
- W184534903 cites W1996930581 @default.
- W184534903 cites W1999782864 @default.
- W184534903 cites W2003899799 @default.
- W184534903 cites W2006841348 @default.
- W184534903 cites W2008519995 @default.
- W184534903 cites W2008787722 @default.
- W184534903 cites W2012333424 @default.
- W184534903 cites W2013901955 @default.
- W184534903 cites W2015898482 @default.
- W184534903 cites W2016863258 @default.
- W184534903 cites W2017597706 @default.
- W184534903 cites W2018449416 @default.
- W184534903 cites W2020166098 @default.
- W184534903 cites W2021042357 @default.
- W184534903 cites W2021496587 @default.
- W184534903 cites W2022962128 @default.
- W184534903 cites W2024363199 @default.
- W184534903 cites W2024815168 @default.
- W184534903 cites W2025571840 @default.
- W184534903 cites W2026140567 @default.
- W184534903 cites W2027066860 @default.
- W184534903 cites W2027429673 @default.
- W184534903 cites W2028242838 @default.
- W184534903 cites W2029272022 @default.
- W184534903 cites W2033828938 @default.
- W184534903 cites W2034450065 @default.
- W184534903 cites W2034878895 @default.
- W184534903 cites W2035197424 @default.
- W184534903 cites W2035473017 @default.
- W184534903 cites W2035884675 @default.
- W184534903 cites W2037518902 @default.
- W184534903 cites W2037746965 @default.
- W184534903 cites W2038940583 @default.
- W184534903 cites W2038963210 @default.
- W184534903 cites W2040900833 @default.
- W184534903 cites W2041492245 @default.
- W184534903 cites W2041962193 @default.
- W184534903 cites W2042415636 @default.