Matches in SemOpenAlex for { <https://semopenalex.org/work/W1845398630> ?p ?o ?g. }
- W1845398630 endingPage "291" @default.
- W1845398630 startingPage "284" @default.
- W1845398630 abstract "This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on learning and memory in a rat model of vascular dementia (VaD) and to analyze the associated mechanisms. Bilateral carotid artery occlusion (2-VO) was used to establish a rat model of VaD. High-frequency (5Hz) rTMS was performed on rats for four weeks. Spatial learning and memory abilities were evaluated using the Morris water maze (MWM), and synaptic plasticity in the hippocampus was assessed via long-term potentiation (LTP). Hippocampal expression of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF) and three subunits of the N-methyl-D-aspartic acid receptor (NMDAR), NR1, NR2A and NR2B, was analyzed by Western blotting. Compared with the VaD group, escape latency was decreased (P<0.05) and the time spent in the target quadrant and the percentage of swimming distance within that quadrant were increased (P<0.05) in the rTMS group. LTP at hippocampal CA3-CA1 synapses was enhanced by rTMS (P<0.05). VEGF expression was up-regulated following 2-VO and was further increased by rTMS (P<0.05). BDNF, NR1 and NR2B expression was decreased in the VaD group and increased by rTMS (P<0.05). There were no significant differences in NR2A expression among the three groups. These results suggest that rTMS improved learning and memory in the VaD model rats via the up-regulation of VEGF, BDNF and NMDARs. In addition, NR2B may be more important than NR2A for LTP induction in the hippocampus during rTMS treatment of VaD." @default.
- W1845398630 created "2016-06-24" @default.
- W1845398630 creator A5006718110 @default.
- W1845398630 creator A5018679012 @default.
- W1845398630 creator A5032436137 @default.
- W1845398630 creator A5034581128 @default.
- W1845398630 creator A5037261030 @default.
- W1845398630 date "2015-12-01" @default.
- W1845398630 modified "2023-10-16" @default.
- W1845398630 title "Repetitive transcranial magnetic stimulation enhances spatial learning and synaptic plasticity via the VEGF and BDNF–NMDAR pathways in a rat model of vascular dementia" @default.
- W1845398630 cites W1534266466 @default.
- W1845398630 cites W1569894857 @default.
- W1845398630 cites W1625906005 @default.
- W1845398630 cites W1971043810 @default.
- W1845398630 cites W1977315137 @default.
- W1845398630 cites W1986214404 @default.
- W1845398630 cites W1991551796 @default.
- W1845398630 cites W1994524727 @default.
- W1845398630 cites W1999522424 @default.
- W1845398630 cites W2003722700 @default.
- W1845398630 cites W2007554700 @default.
- W1845398630 cites W2011161982 @default.
- W1845398630 cites W2012164063 @default.
- W1845398630 cites W2018213389 @default.
- W1845398630 cites W2018775173 @default.
- W1845398630 cites W2020819860 @default.
- W1845398630 cites W2027443706 @default.
- W1845398630 cites W2028257011 @default.
- W1845398630 cites W2028594041 @default.
- W1845398630 cites W2037426713 @default.
- W1845398630 cites W2049752408 @default.
- W1845398630 cites W2053930823 @default.
- W1845398630 cites W2058485466 @default.
- W1845398630 cites W2063017515 @default.
- W1845398630 cites W2067040581 @default.
- W1845398630 cites W2072804683 @default.
- W1845398630 cites W2076880656 @default.
- W1845398630 cites W2078029457 @default.
- W1845398630 cites W2078701991 @default.
- W1845398630 cites W2084311108 @default.
- W1845398630 cites W2088307620 @default.
- W1845398630 cites W2110717207 @default.
- W1845398630 cites W2111396305 @default.
- W1845398630 cites W2127231794 @default.
- W1845398630 cites W2128658611 @default.
- W1845398630 cites W2140262445 @default.
- W1845398630 cites W2142433488 @default.
- W1845398630 cites W2146534357 @default.
- W1845398630 cites W2157633414 @default.
- W1845398630 cites W2161638202 @default.
- W1845398630 cites W2524178063 @default.
- W1845398630 doi "https://doi.org/10.1016/j.neuroscience.2015.10.038" @default.
- W1845398630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26518460" @default.
- W1845398630 hasPublicationYear "2015" @default.
- W1845398630 type Work @default.
- W1845398630 sameAs 1845398630 @default.
- W1845398630 citedByCount "73" @default.
- W1845398630 countsByYear W18453986302015 @default.
- W1845398630 countsByYear W18453986302016 @default.
- W1845398630 countsByYear W18453986302017 @default.
- W1845398630 countsByYear W18453986302018 @default.
- W1845398630 countsByYear W18453986302019 @default.
- W1845398630 countsByYear W18453986302020 @default.
- W1845398630 countsByYear W18453986302021 @default.
- W1845398630 countsByYear W18453986302022 @default.
- W1845398630 countsByYear W18453986302023 @default.
- W1845398630 crossrefType "journal-article" @default.
- W1845398630 hasAuthorship W1845398630A5006718110 @default.
- W1845398630 hasAuthorship W1845398630A5018679012 @default.
- W1845398630 hasAuthorship W1845398630A5032436137 @default.
- W1845398630 hasAuthorship W1845398630A5034581128 @default.
- W1845398630 hasAuthorship W1845398630A5037261030 @default.
- W1845398630 hasConcept C12515866 @default.
- W1845398630 hasConcept C126322002 @default.
- W1845398630 hasConcept C148762608 @default.
- W1845398630 hasConcept C15744967 @default.
- W1845398630 hasConcept C160539049 @default.
- W1845398630 hasConcept C167734588 @default.
- W1845398630 hasConcept C169760540 @default.
- W1845398630 hasConcept C170493617 @default.
- W1845398630 hasConcept C24998067 @default.
- W1845398630 hasConcept C25274449 @default.
- W1845398630 hasConcept C2777025900 @default.
- W1845398630 hasConcept C2777952318 @default.
- W1845398630 hasConcept C2778581513 @default.
- W1845398630 hasConcept C2778790584 @default.
- W1845398630 hasConcept C2779134260 @default.
- W1845398630 hasConcept C2779483572 @default.
- W1845398630 hasConcept C2781161787 @default.
- W1845398630 hasConcept C44752575 @default.
- W1845398630 hasConcept C47611674 @default.
- W1845398630 hasConcept C67018056 @default.
- W1845398630 hasConcept C71924100 @default.
- W1845398630 hasConcept C98229152 @default.
- W1845398630 hasConceptScore W1845398630C12515866 @default.
- W1845398630 hasConceptScore W1845398630C126322002 @default.
- W1845398630 hasConceptScore W1845398630C148762608 @default.
- W1845398630 hasConceptScore W1845398630C15744967 @default.