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• W1845409831 abstract "// Qi Liu 1, 2, * , Xu-Wei Cai 1, 2, 3, * , Xiao-Long Fu 1, 2, 3 , Jun-Chao Chen 1, 2 , Jia-Qing Xiang 2, 4 1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China 3 Department of Radiation Oncology, Shanghai Jiaotong University Chest Hospital, Shanghai, China 4 Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China * These authors have contributed equally to this work Correspondence to: Xiao-Long Fu, e-mail: xlfu1964@hotmail.com Keywords: Clinical Section, esophageal carcinoma, radiotherapy, toxicity, intrathoracic stomach Received: May 08, 2015      Accepted: July 24, 2015      Published: August 05, 2015 ABSTRACT Purpose: To identify the tolerance of radiation with a high prescribed dose and predictors for the development of intrathoracic stomach toxicity in patients with thoracic esophageal squamous cell carcinoma (SCC) after esophagectomy followed by gastric conduit reconstruction. Materials and Methods: From 2011 to 2013, 105 patients after esophagectomy were treated with postoperative radiotherapy. The intrathoracic stomach was outlined with the calculation of a dose-volume histogram (DVH) for the initial intended treatment of 6020 cGy or 6300 cGy. The volume of the intrathoracic stomach receiving each dose was recorded at 10-Gy intervals between 10 and 40 Gy and at 5-Gy intervals between 40 and 60 Gy. The grade of toxicities was defined by the National Cancer Institute Common Toxicity Criteria version 4.0. Results: The mean and maximum doses of the intrathoracic stomach were 2449 ± 986 cGy and 6519 ± 406 cGy, respectively. Sixteen (15.2%) and three (2.9%) experienced Common Toxicity Criteria Grade 2 and Grade 3 acute gastric toxicity. There were no Grade 4 toxicities. Fourteen patients (13.3%) exhibited late gastric complications possibly related to radiation. The volume percent of the intrathoracic stomach receiving at least 50 Gy (V 50 ) was strongly associated with the degree of toxicity ( p = 0.024, respectively). Multivariate analysis of patient and treatment-related factors revealed no other significant predictors of severe toxicities. Conclusions: The intrathoracic stomach is well tolerated with a high-dose irradiation for patients with esophageal SCC receiving radiotherapy after esophagectomy. A strong dose-volume relationship exists for the development of Grade 2 acute intrathoracic stomach toxicity in our study." @default.
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• W1845409831 date "2015-08-05" @default.
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• W1845409831 title "Tolerance and dose-volume relationship of intrathoracic stomach irradiation after esophagectomy for patients with thoracic esophageal squamous cell carcinoma" @default.
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• W1845409831 doi "https://doi.org/10.18632/oncotarget.4730" @default.
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