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- W18455313 abstract "Small molecules that bind to any predetermined DNA sequence in the human genome are potentially useful tools for molecular biology and human medicine. Polyamides containing N-methylimidazole (Im) N-methylpyrrole (Py) are cell permeable small molecules that bind DNA according to a set of pairing rules with affinities and specificities similar to many naturally occurring DNA binding proteins. Py-Im polyamides offer a general approach to the chemical regulation of gene expression. We demonstrate here that polyamide containing a DNA alkylating moiety seco-CBI can specifically direct sequence specific DNA alkylation. We can also control the strand of DNA that is alkylated, depending on the enantiomer of seco-CBI used and the orientation of the polyamide relative to the alkylation site (Chapter 2). This class of molecules has been applied to a gene repair system in collaboration with the Baltimore group at Caltech (Chapter 3). Also reported are additional seco-CBI polyamide conjugates synthesized to study other systems (HIV-1 and COX-2) (Appendix 1)." @default.
- W18455313 created "2016-06-24" @default.
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- W18455313 date "2001-01-01" @default.
- W18455313 modified "2023-09-27" @default.
- W18455313 title "Cleavage of DNA by polyamide-seco-CBI conjugates" @default.
- W18455313 doi "https://doi.org/10.7907/fy0f-dw57." @default.
- W18455313 hasPublicationYear "2001" @default.
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