FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1845534504> ?p ?o ?g. }

• W1845534504 endingPage "77" @default.
• W1845534504 startingPage "2369" @default.
• W1845534504 abstract "Prostate cancer is the second leading cause of cancer-related deaths in menin the United States. Genistein is a prominent isoflavonoid found in soy products and has been proposed to be responsible for lowering the rate of prostate cancer in Asians. However, the molecular mechanism(s) by which genistein elicits its effects on prostate cancer cells has not been fully elucidated. We have previously shown that genistein induces apoptosis and inhibits the activation of nuclear factor kappaB (NF-kappaB) pathway, which could be mediated via Akt signaling pathway, the most important survival pathway in cellular signaling. In this study, we investigated whether there is any cross-talk between Akt and NF-kappaB during genistein-induced apoptosis in PC3 prostate cancer cells. We found that genistein inhibits cell growth and induces apoptotic processes in PC3 prostate cancer cells but not in nontumorigenic CRL-2221 human prostate epithelial cells. Immunoprecipitation, kinase assays, and Western blot analysis showed that genistein specifically inhibits Akt kinase activity and abrogates the epidermal growth factor-induced activation of Akt in prostate cancer cells. NF-kappaB DNA-binding analysis and transfection studies with Akt cDNA and NF-kappaB-Luc constructs revealed that Akt transfection results in the induction of NF-kappaB activation and this is completely inhibited by genistein treatment. Moreover, genistein abrogated the epidermal growth factor-induced activation of NF-kappaB, which was mediated via Akt signaling pathway. From these results, we conclude that the inhibition of Akt and NF-kappaB activity and their cross-talk provide a novel mechanism by which genistein inhibits cell growth and induces apoptotic processes in tumorigenic but not in nontumorigenic prostate epithelial cells." @default.
• W1845534504 created "2016-06-24" @default.
• W1845534504 creator A5016748416 @default.
• W1845534504 creator A5042547707 @default.
• W1845534504 date "2002-07-01" @default.
• W1845534504 modified "2023-10-04" @default.
• W1845534504 title "Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway." @default.
• W1845534504 cites W1500729563 @default.
• W1845534504 cites W1509669696 @default.
• W1845534504 cites W1529396499 @default.
• W1845534504 cites W1617532721 @default.
• W1845534504 cites W1656644300 @default.
• W1845534504 cites W1726025741 @default.
• W1845534504 cites W1789961596 @default.
• W1845534504 cites W1888783223 @default.
• W1845534504 cites W1926564796 @default.
• W1845534504 cites W1970751001 @default.
• W1845534504 cites W1982062664 @default.
• W1845534504 cites W1983398917 @default.
• W1845534504 cites W1983668987 @default.
• W1845534504 cites W1989345460 @default.
• W1845534504 cites W1991449455 @default.
• W1845534504 cites W1991720095 @default.
• W1845534504 cites W1993216157 @default.
• W1845534504 cites W1994915896 @default.
• W1845534504 cites W1999447199 @default.
• W1845534504 cites W2000552194 @default.
• W1845534504 cites W2004078164 @default.
• W1845534504 cites W2018926746 @default.
• W1845534504 cites W2024306318 @default.
• W1845534504 cites W2032359283 @default.
• W1845534504 cites W2036843530 @default.
• W1845534504 cites W2037250108 @default.
• W1845534504 cites W2044416896 @default.
• W1845534504 cites W2044868069 @default.
• W1845534504 cites W2052512448 @default.
• W1845534504 cites W2053265248 @default.
• W1845534504 cites W2057184021 @default.
• W1845534504 cites W2062205148 @default.
• W1845534504 cites W2070942270 @default.
• W1845534504 cites W2079003739 @default.
• W1845534504 cites W2084166320 @default.
• W1845534504 cites W2095296343 @default.
• W1845534504 cites W2098185216 @default.
• W1845534504 cites W2108319912 @default.
• W1845534504 cites W2115207474 @default.
• W1845534504 cites W2137035181 @default.
• W1845534504 cites W2143965341 @default.
• W1845534504 cites W2144300167 @default.
• W1845534504 cites W2147114673 @default.
• W1845534504 cites W2169618540 @default.
• W1845534504 cites W2180159320 @default.
• W1845534504 cites W2318098003 @default.
• W1845534504 cites W2411322203 @default.
• W1845534504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12114442" @default.
• W1845534504 hasPublicationYear "2002" @default.
• W1845534504 type Work @default.
• W1845534504 sameAs 1845534504 @default.
• W1845534504 citedByCount "75" @default.
• W1845534504 countsByYear W18455345042012 @default.
• W1845534504 countsByYear W18455345042013 @default.
• W1845534504 countsByYear W18455345042014 @default.
• W1845534504 countsByYear W18455345042015 @default.
• W1845534504 countsByYear W18455345042016 @default.
• W1845534504 countsByYear W18455345042017 @default.
• W1845534504 countsByYear W18455345042018 @default.
• W1845534504 countsByYear W18455345042019 @default.
• W1845534504 countsByYear W18455345042020 @default.
• W1845534504 countsByYear W18455345042021 @default.
• W1845534504 countsByYear W18455345042022 @default.
• W1845534504 countsByYear W18455345042023 @default.
• W1845534504 crossrefType "journal-article" @default.
• W1845534504 hasAuthorship W1845534504A5016748416 @default.
• W1845534504 hasAuthorship W1845534504A5042547707 @default.
• W1845534504 hasConcept C121608353 @default.
• W1845534504 hasConcept C126322002 @default.
• W1845534504 hasConcept C134018914 @default.
• W1845534504 hasConcept C185592680 @default.
• W1845534504 hasConcept C190283241 @default.
• W1845534504 hasConcept C2778298627 @default.
• W1845534504 hasConcept C2780192828 @default.
• W1845534504 hasConcept C502942594 @default.
• W1845534504 hasConcept C55493867 @default.
• W1845534504 hasConcept C62478195 @default.
• W1845534504 hasConcept C71924100 @default.
• W1845534504 hasConcept C75217442 @default.
• W1845534504 hasConcept C86554907 @default.
• W1845534504 hasConcept C86803240 @default.
• W1845534504 hasConcept C95444343 @default.
• W1845534504 hasConceptScore W1845534504C121608353 @default.
• W1845534504 hasConceptScore W1845534504C126322002 @default.
• W1845534504 hasConceptScore W1845534504C134018914 @default.
• W1845534504 hasConceptScore W1845534504C185592680 @default.
• W1845534504 hasConceptScore W1845534504C190283241 @default.
• W1845534504 hasConceptScore W1845534504C2778298627 @default.
• W1845534504 hasConceptScore W1845534504C2780192828 @default.
• W1845534504 hasConceptScore W1845534504C502942594 @default.
• W1845534504 hasConceptScore W1845534504C55493867 @default.

• next