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• W184554100 endingPage "344" @default.
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• W184554100 abstract "The beta-amyloid precursor, a neuronal and glial-derived protein, demonstrates trophic-like activities. The major constituent of amyloid deposits has been identified as a 39–42 amino acid protein termed beta/A4, which is not synthesized by cells as a free protein but rather is a domain contained within a family of larger proteins, the beta amyloid precursor proteins (APPs). The small subdomains of APPs, within the beta/A4 domain and the beta/A4 region itself, have also been shown to possess neurotrophic-like activities. Both beta/A4 1–28 and 25–35 reportedly enhance the survival of cultured hippocampal neurons, while the entire beta/A4 can increase both survival and neuritic branching. This neurotrophic activity is particularly relevant to the amyloid deposition of aging and Alzheimer's disease. In the amyloid deposits referred to as neuritic plaques, a central core of amyloid is surrounded by invading neuronal processes. It has been suggested that the neurotrophic activity of beta/A4 and its subdomains observed in cell culture may be responsible for the aberrant process growth found in neuritic plaques. If this hypothesis is correct, then the APPs or their fragments can elicit neurotrophic effects in the mature human central nervous system." @default.
• W184554100 created "2016-06-24" @default.
• W184554100 creator A5039538989 @default.
• W184554100 date "1994-01-01" @default.
• W184554100 modified "2023-09-26" @default.
• W184554100 title "Beta-Amyloid Precursor: A Neuronal and Glial-Derived Protein With Trophic-like Activities" @default.
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• W184554100 doi "https://doi.org/10.1016/b978-0-08-042276-3.50025-2" @default.
• W184554100 hasPublicationYear "1994" @default.
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