Matches in SemOpenAlex for { <https://semopenalex.org/work/W1845562660> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1845562660 startingPage "1938" @default.
- W1845562660 abstract "A normal sputum eosinophil count in children with asthma could result from corticosteroid treatment or reduction in eosinophil recruitment. In order to differentiate this we have described a new marker of eosinophilic inflammation (eosinophil protein content in airway macrophages) 1 . At high altitude children with asthma show significant reduction in eosinophil count due to reduced exposure to allergens. The aim was to determine the macrophage eosinophil protein content at baseline (T0) and after stay at high altitude (T1). Sputum induction was performed at T0 (n=54) and T1 in children attending High Altitude Children9s Asthma Center in Misurina. Differential count was obtained by counting 400 non-squamous cells (eosinophilic asthma defined as ≥ 3%). One hundred macrophages were imaged at high-resolution using digital camera. The percentage of macrophage cytoplasm with red hue was determined by image analysis. The groups were compared using Mann-Whitney and Wilcoxon t tests. There was no significant difference (p=0.39) between median airway macrophages (AM) red hue percentage in eosinophilic (n=30) [median (range)] [5.9(0.6-57.6)] and non-eosinophilic asthma (n=24) [8.7(0.34-71.2)]. Children at T1 had significantly lower i) eosinophil count Median (range) [p = 0.001, 1(0-30) vs 3(0-52)] ii) AM red hue percentage [p = 0.005, 3.82(0.41-59.82) vs 7.04(0.72-71.23)] than at T0. The high AM red hue in non-eosinophilic asthma on arrival suggests ongoing eosinophilia in the absence of sputum eosinophilia. The reduction in eosinophil count after stay at high altitude is due to reduction in eosinophil recruitment in airways. 1 Kulkarni NS et al. JACI 2010; 126(1):61-9." @default.
- W1845562660 created "2016-06-24" @default.
- W1845562660 creator A5009557204 @default.
- W1845562660 creator A5009716124 @default.
- W1845562660 creator A5058642614 @default.
- W1845562660 creator A5059318775 @default.
- W1845562660 creator A5063056118 @default.
- W1845562660 date "2012-09-01" @default.
- W1845562660 modified "2023-09-24" @default.
- W1845562660 title "High altitude stay reduces eosinophil load in airways in children with asthma" @default.
- W1845562660 hasPublicationYear "2012" @default.
- W1845562660 type Work @default.
- W1845562660 sameAs 1845562660 @default.
- W1845562660 citedByCount "0" @default.
- W1845562660 crossrefType "journal-article" @default.
- W1845562660 hasAuthorship W1845562660A5009557204 @default.
- W1845562660 hasAuthorship W1845562660A5009716124 @default.
- W1845562660 hasAuthorship W1845562660A5058642614 @default.
- W1845562660 hasAuthorship W1845562660A5059318775 @default.
- W1845562660 hasAuthorship W1845562660A5063056118 @default.
- W1845562660 hasConcept C126322002 @default.
- W1845562660 hasConcept C142724271 @default.
- W1845562660 hasConcept C203014093 @default.
- W1845562660 hasConcept C2776042228 @default.
- W1845562660 hasConcept C2776301714 @default.
- W1845562660 hasConcept C2777037409 @default.
- W1845562660 hasConcept C2777129736 @default.
- W1845562660 hasConcept C2779758542 @default.
- W1845562660 hasConcept C2781069245 @default.
- W1845562660 hasConcept C71924100 @default.
- W1845562660 hasConceptScore W1845562660C126322002 @default.
- W1845562660 hasConceptScore W1845562660C142724271 @default.
- W1845562660 hasConceptScore W1845562660C203014093 @default.
- W1845562660 hasConceptScore W1845562660C2776042228 @default.
- W1845562660 hasConceptScore W1845562660C2776301714 @default.
- W1845562660 hasConceptScore W1845562660C2777037409 @default.
- W1845562660 hasConceptScore W1845562660C2777129736 @default.
- W1845562660 hasConceptScore W1845562660C2779758542 @default.
- W1845562660 hasConceptScore W1845562660C2781069245 @default.
- W1845562660 hasConceptScore W1845562660C71924100 @default.
- W1845562660 hasLocation W18455626601 @default.
- W1845562660 hasOpenAccess W1845562660 @default.
- W1845562660 hasPrimaryLocation W18455626601 @default.
- W1845562660 hasRelatedWork W1792893088 @default.
- W1845562660 hasRelatedWork W1965004443 @default.
- W1845562660 hasRelatedWork W1981352040 @default.
- W1845562660 hasRelatedWork W2004841690 @default.
- W1845562660 hasRelatedWork W2022519715 @default.
- W1845562660 hasRelatedWork W2044195459 @default.
- W1845562660 hasRelatedWork W2068672427 @default.
- W1845562660 hasRelatedWork W2090845093 @default.
- W1845562660 hasRelatedWork W2122859296 @default.
- W1845562660 hasRelatedWork W2141746492 @default.
- W1845562660 hasRelatedWork W2380989114 @default.
- W1845562660 hasRelatedWork W2392821530 @default.
- W1845562660 hasRelatedWork W2417832395 @default.
- W1845562660 hasRelatedWork W2513744769 @default.
- W1845562660 hasRelatedWork W2596545940 @default.
- W1845562660 hasRelatedWork W2613974366 @default.
- W1845562660 hasRelatedWork W2713960321 @default.
- W1845562660 hasRelatedWork W2941604577 @default.
- W1845562660 hasRelatedWork W2989591778 @default.
- W1845562660 hasRelatedWork W944834729 @default.
- W1845562660 hasVolume "40" @default.
- W1845562660 isParatext "false" @default.
- W1845562660 isRetracted "false" @default.
- W1845562660 magId "1845562660" @default.
- W1845562660 workType "article" @default.