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• W184557018 endingPage "56" @default.
• W184557018 startingPage "25" @default.
• W184557018 abstract "The concept that body adiposity is homeostatically regulated is rooted in the observation that most mammals maintain a stable level of adiposity over long time periods. Since the amount of the body’s energy that is stored as adipose tissue is determined by the net difference between caloric intake and expenditure, this observation suggested to early investigators that energy intake and expenditure must be balanced with some precision (1,2). Rejecting the notion that maintenance of energy balance could be achieved by random processes, investigators proposed many decades ago that food intake and adipose mass are coupled elements of a homeostatic regulatory loop. This view was supported by the discovery that changes in energy expenditure and adiposity elicit compensatory changes in caloric intake. In 1953, these observations led Kennedy (3) to propose that changes in body adiposity are signaled to the brain, thereby modifying the drive to eat. Subsequently, other investigators postulated that a change in adiposity also elicits adaptive changes in energy expenditure, a view now supported by a large body of literature (1,4) that includes studies in humans (5). Through these mechanisms, adiposity-proportional afferent signals were proposed to enable the brain to restore adipose mass to its regulated level. Obesity was viewed, therefore, as a disorder arising from impaired body weight regulation, rather than a lack of dietary restraint." @default.
• W184557018 created "2016-06-24" @default.
• W184557018 creator A5031570303 @default.
• W184557018 creator A5035450241 @default.
• W184557018 creator A5053926256 @default.
• W184557018 creator A5056280591 @default.
• W184557018 creator A5068589244 @default.
• W184557018 date "1997-01-01" @default.
• W184557018 modified "2023-09-26" @default.
• W184557018 title "Regulation of Food Intake and Body Weight" @default.
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