Matches in SemOpenAlex for { <https://semopenalex.org/work/W1845579223> ?p ?o ?g. }
- W1845579223 endingPage "131" @default.
- W1845579223 startingPage "119" @default.
- W1845579223 abstract "Abstract The ability to utilize formamide as a sole nitrogen source has been found in numerous fungi. We have cloned the fmdS gene encoding a formamidase from Aspergillus nidulans and found that it belongs to a highly conserved family of proteins separate from the major amidase families. The expression of fmdS is primarily regulated via AreA-mediated nitrogen metabolite repression and does not require the addition of exogenous inducer. Consistent with this, deletion analysis of the 5′ region of fmdS has confirmed the presence of multiple AreA-binding sites containing a characteristic core GATA sequence. Under carbon starvation conditions the response to nitrogen starvation is eliminated, indicating that the lack of a carbon source may result in inactivation of AreA. Sequence analysis and isolation of cDNAs show that a gene of unknown function lies directly 5′ of fmdS with its transcript overlapping the fmdS coding region. Disruption of the 5′ gene and analysis of the effects of overexpression of this gene on fmdS expression has shown that expression of this upstream gene interferes with fmdS transcription, resulting in a strong dependence on AreA activation for expression. Therefore the relative position of these two genes is essential for normal regulation of fmdS." @default.
- W1845579223 created "2016-06-24" @default.
- W1845579223 creator A5026285748 @default.
- W1845579223 creator A5065433879 @default.
- W1845579223 creator A5077183687 @default.
- W1845579223 date "2001-01-01" @default.
- W1845579223 modified "2023-10-18" @default.
- W1845579223 title "The Formamidase Gene of <i>Aspergillus nidulans</i>: Regulation by Nitrogen Metabolite Repression and Transcriptional Interference by an Overlapping Upstream Gene" @default.
- W1845579223 cites W111070886 @default.
- W1845579223 cites W13114793 @default.
- W1845579223 cites W1505074178 @default.
- W1845579223 cites W1578400073 @default.
- W1845579223 cites W1602246888 @default.
- W1845579223 cites W1619835139 @default.
- W1845579223 cites W1642708277 @default.
- W1845579223 cites W1748687783 @default.
- W1845579223 cites W1800856035 @default.
- W1845579223 cites W1890698840 @default.
- W1845579223 cites W1966797957 @default.
- W1845579223 cites W1966997602 @default.
- W1845579223 cites W1969289848 @default.
- W1845579223 cites W1974325040 @default.
- W1845579223 cites W1981839939 @default.
- W1845579223 cites W1982273124 @default.
- W1845579223 cites W1984633959 @default.
- W1845579223 cites W1984860940 @default.
- W1845579223 cites W1986097297 @default.
- W1845579223 cites W1992066867 @default.
- W1845579223 cites W1993160177 @default.
- W1845579223 cites W1996411013 @default.
- W1845579223 cites W2004635090 @default.
- W1845579223 cites W2006396136 @default.
- W1845579223 cites W2009310436 @default.
- W1845579223 cites W2010490059 @default.
- W1845579223 cites W2011715107 @default.
- W1845579223 cites W2012958702 @default.
- W1845579223 cites W2016367040 @default.
- W1845579223 cites W2019377841 @default.
- W1845579223 cites W2021831279 @default.
- W1845579223 cites W2023286170 @default.
- W1845579223 cites W2023808515 @default.
- W1845579223 cites W2027312376 @default.
- W1845579223 cites W2028997445 @default.
- W1845579223 cites W2035847135 @default.
- W1845579223 cites W2038256171 @default.
- W1845579223 cites W2039731543 @default.
- W1845579223 cites W2039733776 @default.
- W1845579223 cites W2042265890 @default.
- W1845579223 cites W2042476067 @default.
- W1845579223 cites W2050014784 @default.
- W1845579223 cites W2056953003 @default.
- W1845579223 cites W2061057323 @default.
- W1845579223 cites W2061709377 @default.
- W1845579223 cites W2063231382 @default.
- W1845579223 cites W2069053494 @default.
- W1845579223 cites W2071622548 @default.
- W1845579223 cites W2074122548 @default.
- W1845579223 cites W2081597640 @default.
- W1845579223 cites W2088436037 @default.
- W1845579223 cites W2094703583 @default.
- W1845579223 cites W2097272632 @default.
- W1845579223 cites W2100605571 @default.
- W1845579223 cites W2102490281 @default.
- W1845579223 cites W2106269300 @default.
- W1845579223 cites W2108527233 @default.
- W1845579223 cites W2122726565 @default.
- W1845579223 cites W2130277750 @default.
- W1845579223 cites W2131672637 @default.
- W1845579223 cites W2131836407 @default.
- W1845579223 cites W2133859068 @default.
- W1845579223 cites W2138049951 @default.
- W1845579223 cites W214054806 @default.
- W1845579223 cites W2149495934 @default.
- W1845579223 cites W2152170489 @default.
- W1845579223 cites W2158906453 @default.
- W1845579223 cites W2170598748 @default.
- W1845579223 cites W2171809401 @default.
- W1845579223 cites W2439090859 @default.
- W1845579223 cites W37485712 @default.
- W1845579223 doi "https://doi.org/10.1093/genetics/157.1.119" @default.
- W1845579223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1461490" @default.
- W1845579223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11139496" @default.
- W1845579223 hasPublicationYear "2001" @default.
- W1845579223 type Work @default.
- W1845579223 sameAs 1845579223 @default.
- W1845579223 citedByCount "46" @default.
- W1845579223 countsByYear W18455792232012 @default.
- W1845579223 countsByYear W18455792232014 @default.
- W1845579223 countsByYear W18455792232016 @default.
- W1845579223 countsByYear W18455792232017 @default.
- W1845579223 countsByYear W18455792232018 @default.
- W1845579223 countsByYear W18455792232019 @default.
- W1845579223 countsByYear W18455792232020 @default.
- W1845579223 countsByYear W18455792232021 @default.
- W1845579223 countsByYear W18455792232022 @default.
- W1845579223 countsByYear W18455792232023 @default.
- W1845579223 crossrefType "journal-article" @default.
- W1845579223 hasAuthorship W1845579223A5026285748 @default.