Matches in SemOpenAlex for { <https://semopenalex.org/work/W1845625660> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1845625660 endingPage "846" @default.
- W1845625660 startingPage "842" @default.
- W1845625660 abstract "Abstract: Leptin is an anorexigenic peptide which is synthesized in white adipose tissue. The actions of leptin are mediated by the leptin receptor which is abundantly localized in the hypothalamus and is involved in energy regulation and balance. Recently, there has been evidence suggesting that the leptin receptor is also present in the hippocampus and may be involved with hippocampal excitability and long-term depression. To investigate the physiological function of leptin signalling in the hippocampus, we studied the effects of leptin on methamphetamine-induced ambulatory hyperactivity by utilizing intra-hippocampal infusion (i.h.) in mice. Our results show that the infusion of leptin (5 ng each bilaterally i.h.) does not affect the basal ambulatory activity but significantly suppresses methamphetamine-induced ambulatory hyperactivity as compared to saline-infused controls. Interestingly, higher dose of leptin increases the suppression of the methamphetamine-induced ambulatory hyperactivity. The i.h. infusion of leptin did not activate the JAK-STAT pathway, which is the cellular signalling pathway through which leptin acts in the hypothalamus. The infusion of leptin also did not affect activation of p42/44 MAPK which is known to be another leptin-induced signalling pathway in the brain. These results demonstrate that leptin has a novel potential suppressive effect on methamphetamine-induced hyperlocomotion and also suggest that there must be an alternative pathway in the hippocampus through which leptin signalling is being mediated." @default.
- W1845625660 created "2016-06-24" @default.
- W1845625660 creator A5060746663 @default.
- W1845625660 creator A5078287634 @default.
- W1845625660 date "2010-09-15" @default.
- W1845625660 modified "2023-09-23" @default.
- W1845625660 title "Hippocampal Leptin Suppresses Methamphetamine-Induced Hyperlocomotion" @default.
- W1845625660 cites W1486463812 @default.
- W1845625660 cites W1604789859 @default.
- W1845625660 cites W1900852307 @default.
- W1845625660 cites W1910514939 @default.
- W1845625660 cites W1991906822 @default.
- W1845625660 cites W1996713062 @default.
- W1845625660 cites W1997012827 @default.
- W1845625660 cites W2001585610 @default.
- W1845625660 cites W2013583119 @default.
- W1845625660 cites W2016994959 @default.
- W1845625660 cites W2017189350 @default.
- W1845625660 cites W2024484448 @default.
- W1845625660 cites W2025846514 @default.
- W1845625660 cites W2030450036 @default.
- W1845625660 cites W2038295103 @default.
- W1845625660 cites W2056383195 @default.
- W1845625660 cites W2062644092 @default.
- W1845625660 cites W2070216489 @default.
- W1845625660 cites W2091643921 @default.
- W1845625660 cites W2098009730 @default.
- W1845625660 cites W2142122734 @default.
- W1845625660 cites W2409325799 @default.
- W1845625660 doi "https://doi.org/10.1111/j.1742-7843.2010.00591.x" @default.
- W1845625660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20486923" @default.
- W1845625660 hasPublicationYear "2010" @default.
- W1845625660 type Work @default.
- W1845625660 sameAs 1845625660 @default.
- W1845625660 citedByCount "1" @default.
- W1845625660 countsByYear W18456256602018 @default.
- W1845625660 crossrefType "journal-article" @default.
- W1845625660 hasAuthorship W1845625660A5060746663 @default.
- W1845625660 hasAuthorship W1845625660A5078287634 @default.
- W1845625660 hasBestOaLocation W18456256601 @default.
- W1845625660 hasConcept C126322002 @default.
- W1845625660 hasConcept C134018914 @default.
- W1845625660 hasConcept C14372207 @default.
- W1845625660 hasConcept C148762608 @default.
- W1845625660 hasConcept C170493617 @default.
- W1845625660 hasConcept C171089720 @default.
- W1845625660 hasConcept C185592680 @default.
- W1845625660 hasConcept C2491326 @default.
- W1845625660 hasConcept C2777003273 @default.
- W1845625660 hasConcept C2780376393 @default.
- W1845625660 hasConcept C2780613262 @default.
- W1845625660 hasConcept C2781161787 @default.
- W1845625660 hasConcept C511355011 @default.
- W1845625660 hasConcept C71924100 @default.
- W1845625660 hasConceptScore W1845625660C126322002 @default.
- W1845625660 hasConceptScore W1845625660C134018914 @default.
- W1845625660 hasConceptScore W1845625660C14372207 @default.
- W1845625660 hasConceptScore W1845625660C148762608 @default.
- W1845625660 hasConceptScore W1845625660C170493617 @default.
- W1845625660 hasConceptScore W1845625660C171089720 @default.
- W1845625660 hasConceptScore W1845625660C185592680 @default.
- W1845625660 hasConceptScore W1845625660C2491326 @default.
- W1845625660 hasConceptScore W1845625660C2777003273 @default.
- W1845625660 hasConceptScore W1845625660C2780376393 @default.
- W1845625660 hasConceptScore W1845625660C2780613262 @default.
- W1845625660 hasConceptScore W1845625660C2781161787 @default.
- W1845625660 hasConceptScore W1845625660C511355011 @default.
- W1845625660 hasConceptScore W1845625660C71924100 @default.
- W1845625660 hasIssue "4" @default.
- W1845625660 hasLocation W18456256601 @default.
- W1845625660 hasLocation W18456256602 @default.
- W1845625660 hasOpenAccess W1845625660 @default.
- W1845625660 hasPrimaryLocation W18456256601 @default.
- W1845625660 hasRelatedWork W1971511738 @default.
- W1845625660 hasRelatedWork W1976946227 @default.
- W1845625660 hasRelatedWork W1981396719 @default.
- W1845625660 hasRelatedWork W2001196812 @default.
- W1845625660 hasRelatedWork W2036826028 @default.
- W1845625660 hasRelatedWork W2052912427 @default.
- W1845625660 hasRelatedWork W2091225147 @default.
- W1845625660 hasRelatedWork W2170321707 @default.
- W1845625660 hasRelatedWork W2313922371 @default.
- W1845625660 hasRelatedWork W2398688629 @default.
- W1845625660 hasVolume "107" @default.
- W1845625660 isParatext "false" @default.
- W1845625660 isRetracted "false" @default.
- W1845625660 magId "1845625660" @default.
- W1845625660 workType "article" @default.