Matches in SemOpenAlex for { <https://semopenalex.org/work/W1845642859> ?p ?o ?g. }
- W1845642859 endingPage "171" @default.
- W1845642859 startingPage "157" @default.
- W1845642859 abstract "A key feature of the response of the CNS to injury and disease is a tightly regulated synthesis of a number of immunoregulatory cytokines, like interleukin-1 (IL-1) (Fagan and Gage, 1990; Wang et al., 1997) and IL-6 (Wang et al., 1995), tumor necrosis factor (TNF) (Wang et al., 1997) and transforming growth factor beta 1 (TGFβ1) (Lehrmann et al., 1998; Morgan et al., 1993), which in the presence of T-cells may be supplemented by the additional presence of interferon gamma (IFNγ) (Merrill et al., 1992; Renno et al., 1995). Although the biological functions of these and other cytokines have been extensively investigated in vitro(Aloisi et al, 1995; D’Souza et al., 1996; Frei et al., 1987; Merrill, 1991; Merrill and Benveniste, 1996; Sawada et al., 1989), no clear concept has emerged as to their functions on neurons and glia in vivo.In this study, we have investigated the role of IFNγ and TNF on axotomy-induced microglial and oligodendrocyte activation, by applying a well-characterized axonal lesion model, the so-called perforant path (PP) lesion paradigm (Fagan and Gage, 1994; Jensen et al., 1994; Lynch et al., 1972; Matthews et al., 1976a,b) to transgenic mice with myelin basic protein (MBP) promoter driven expression of IFNγ (Renno et al., 1998) or TNF (Taupin et al., 1997) in their CNS." @default.
- W1845642859 created "2016-06-24" @default.
- W1845642859 creator A5040577561 @default.
- W1845642859 creator A5054164188 @default.
- W1845642859 creator A5064953301 @default.
- W1845642859 creator A5076125351 @default.
- W1845642859 creator A5079171781 @default.
- W1845642859 creator A5088948223 @default.
- W1845642859 date "1999-01-01" @default.
- W1845642859 modified "2023-09-27" @default.
- W1845642859 title "Axotomy-Induced Glial Reactions in Normal and Cytokine Transgenic Mice" @default.
- W1845642859 cites W112189813 @default.
- W1845642859 cites W1512112524 @default.
- W1845642859 cites W1524211161 @default.
- W1845642859 cites W1526247294 @default.
- W1845642859 cites W1555113073 @default.
- W1845642859 cites W1846750166 @default.
- W1845642859 cites W1963920303 @default.
- W1845642859 cites W1966027175 @default.
- W1845642859 cites W1970719411 @default.
- W1845642859 cites W1974439206 @default.
- W1845642859 cites W1974869833 @default.
- W1845642859 cites W1976702427 @default.
- W1845642859 cites W1979195270 @default.
- W1845642859 cites W1979529470 @default.
- W1845642859 cites W1980156116 @default.
- W1845642859 cites W1981420390 @default.
- W1845642859 cites W1983763140 @default.
- W1845642859 cites W1984968088 @default.
- W1845642859 cites W1991763618 @default.
- W1845642859 cites W1992172737 @default.
- W1845642859 cites W1993269481 @default.
- W1845642859 cites W1997451049 @default.
- W1845642859 cites W1999075359 @default.
- W1845642859 cites W2001592436 @default.
- W1845642859 cites W2001751662 @default.
- W1845642859 cites W2006593236 @default.
- W1845642859 cites W2009588334 @default.
- W1845642859 cites W2011677372 @default.
- W1845642859 cites W2014997725 @default.
- W1845642859 cites W2015153348 @default.
- W1845642859 cites W2018421371 @default.
- W1845642859 cites W2018777561 @default.
- W1845642859 cites W2020357090 @default.
- W1845642859 cites W2021372734 @default.
- W1845642859 cites W2023634037 @default.
- W1845642859 cites W2024476573 @default.
- W1845642859 cites W2025392129 @default.
- W1845642859 cites W2025522339 @default.
- W1845642859 cites W2026497353 @default.
- W1845642859 cites W2027953622 @default.
- W1845642859 cites W2028989796 @default.
- W1845642859 cites W2029401699 @default.
- W1845642859 cites W2032124268 @default.
- W1845642859 cites W2033835887 @default.
- W1845642859 cites W2034882426 @default.
- W1845642859 cites W2036528355 @default.
- W1845642859 cites W2040630561 @default.
- W1845642859 cites W2042109148 @default.
- W1845642859 cites W2042759317 @default.
- W1845642859 cites W2047025991 @default.
- W1845642859 cites W2049529908 @default.
- W1845642859 cites W2061642062 @default.
- W1845642859 cites W2061747759 @default.
- W1845642859 cites W2062030300 @default.
- W1845642859 cites W2062406681 @default.
- W1845642859 cites W2063094517 @default.
- W1845642859 cites W2063504330 @default.
- W1845642859 cites W2063842801 @default.
- W1845642859 cites W2064329226 @default.
- W1845642859 cites W2072552650 @default.
- W1845642859 cites W2073611490 @default.
- W1845642859 cites W2075350153 @default.
- W1845642859 cites W2076264160 @default.
- W1845642859 cites W2076651424 @default.
- W1845642859 cites W2076826709 @default.
- W1845642859 cites W2077896051 @default.
- W1845642859 cites W2083161329 @default.
- W1845642859 cites W2083464618 @default.
- W1845642859 cites W2085528097 @default.
- W1845642859 cites W2085921234 @default.
- W1845642859 cites W2086654320 @default.
- W1845642859 cites W2087001573 @default.
- W1845642859 cites W2089172549 @default.
- W1845642859 cites W2093252941 @default.
- W1845642859 cites W2112870118 @default.
- W1845642859 cites W2139617720 @default.
- W1845642859 cites W2140644257 @default.
- W1845642859 cites W2144232114 @default.
- W1845642859 cites W2157584173 @default.
- W1845642859 cites W4301965163 @default.
- W1845642859 cites W4313333659 @default.
- W1845642859 doi "https://doi.org/10.1007/978-1-4615-4685-6_13" @default.
- W1845642859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10635027" @default.
- W1845642859 hasPublicationYear "1999" @default.
- W1845642859 type Work @default.
- W1845642859 sameAs 1845642859 @default.
- W1845642859 citedByCount "24" @default.