Matches in SemOpenAlex for { <https://semopenalex.org/work/W1845691611> ?p ?o ?g. }
- W1845691611 endingPage "261" @default.
- W1845691611 startingPage "243" @default.
- W1845691611 abstract "Lack of physical activity (PA) is a risk factor for Alzheimer's disease (AD), and PA interventions are believed to provide an effective non-pharmacological approach for attenuating the symptoms of this disease. However, the mechanism of action of these positive effects is currently unknown. It is possible that the benefits may be at least partially mediated by the effects on the neuroendocrine stress system. Chronic stress can lead to dysfunction of the hypothalamic–pituitary–adrenal (HPA) axis, leading to aberrant basal and circadian patterns of cortisol secretion and a cascade of negative downstream events. These factors have been linked not only to reduced cognitive function but also increased levels of amyloid-β plaques and protein tau “tangles” (the neuropathological hallmarks of AD) in the non-demented mouse models of this disease. However, there is evidence that PA can have restorative effects on the stress neuroendocrine system and related risk factors relevant to AD. We explore the possibility that PA can positively impact upon AD by restoring normative HPA axis function, with consequent downstream effects upon underlying neuropathology and associated cognitive function. We conclude with suggestions for future research to test this hypothesis in patients with AD." @default.
- W1845691611 created "2016-06-24" @default.
- W1845691611 creator A5034942448 @default.
- W1845691611 creator A5035398016 @default.
- W1845691611 date "2012-01-04" @default.
- W1845691611 modified "2023-09-27" @default.
- W1845691611 title "Does physical activity reduce risk for Alzheimer's disease through interaction with the stress neuroendocrine system?" @default.
- W1845691611 cites W140387039 @default.
- W1845691611 cites W1486406005 @default.
- W1845691611 cites W1566636169 @default.
- W1845691611 cites W1640586950 @default.
- W1845691611 cites W1899025964 @default.
- W1845691611 cites W1924478105 @default.
- W1845691611 cites W1959902108 @default.
- W1845691611 cites W1969412681 @default.
- W1845691611 cites W1971334793 @default.
- W1845691611 cites W1972308165 @default.
- W1845691611 cites W1972706926 @default.
- W1845691611 cites W1973637060 @default.
- W1845691611 cites W1974876735 @default.
- W1845691611 cites W1977831713 @default.
- W1845691611 cites W1977977170 @default.
- W1845691611 cites W1979410529 @default.
- W1845691611 cites W1983242089 @default.
- W1845691611 cites W1986733770 @default.
- W1845691611 cites W1989605260 @default.
- W1845691611 cites W1989716486 @default.
- W1845691611 cites W1991189029 @default.
- W1845691611 cites W1991460472 @default.
- W1845691611 cites W1992091136 @default.
- W1845691611 cites W1993460228 @default.
- W1845691611 cites W1994631256 @default.
- W1845691611 cites W1997837704 @default.
- W1845691611 cites W1998099581 @default.
- W1845691611 cites W1998938363 @default.
- W1845691611 cites W1999664376 @default.
- W1845691611 cites W2000413717 @default.
- W1845691611 cites W2000446523 @default.
- W1845691611 cites W2001610698 @default.
- W1845691611 cites W2005078651 @default.
- W1845691611 cites W2005229523 @default.
- W1845691611 cites W2006119116 @default.
- W1845691611 cites W2008719521 @default.
- W1845691611 cites W2009057289 @default.
- W1845691611 cites W2011027597 @default.
- W1845691611 cites W2011474285 @default.
- W1845691611 cites W2011988006 @default.
- W1845691611 cites W2014508157 @default.
- W1845691611 cites W2014904735 @default.
- W1845691611 cites W2015629132 @default.
- W1845691611 cites W2016485258 @default.
- W1845691611 cites W2020205666 @default.
- W1845691611 cites W2020291960 @default.
- W1845691611 cites W2021551531 @default.
- W1845691611 cites W2023899218 @default.
- W1845691611 cites W2024594664 @default.
- W1845691611 cites W2025068068 @default.
- W1845691611 cites W2025193019 @default.
- W1845691611 cites W2025937166 @default.
- W1845691611 cites W2026637030 @default.
- W1845691611 cites W2028763483 @default.
- W1845691611 cites W2028911700 @default.
- W1845691611 cites W2029395333 @default.
- W1845691611 cites W2029853631 @default.
- W1845691611 cites W2030265072 @default.
- W1845691611 cites W2031353556 @default.
- W1845691611 cites W2033220940 @default.
- W1845691611 cites W2034005382 @default.
- W1845691611 cites W2035505256 @default.
- W1845691611 cites W2036234078 @default.
- W1845691611 cites W2036362108 @default.
- W1845691611 cites W2036672386 @default.
- W1845691611 cites W2037732259 @default.
- W1845691611 cites W2038145816 @default.
- W1845691611 cites W2038839492 @default.
- W1845691611 cites W2039959685 @default.
- W1845691611 cites W2041342674 @default.
- W1845691611 cites W2042044062 @default.
- W1845691611 cites W2042415483 @default.
- W1845691611 cites W2043605366 @default.
- W1845691611 cites W2044021535 @default.
- W1845691611 cites W2044406911 @default.
- W1845691611 cites W2044445029 @default.
- W1845691611 cites W2044987522 @default.
- W1845691611 cites W2046177214 @default.
- W1845691611 cites W2046807434 @default.
- W1845691611 cites W2047073953 @default.
- W1845691611 cites W2047179725 @default.
- W1845691611 cites W2047318846 @default.
- W1845691611 cites W2052588755 @default.
- W1845691611 cites W2053032855 @default.
- W1845691611 cites W2053298975 @default.
- W1845691611 cites W2053712773 @default.
- W1845691611 cites W2055461003 @default.
- W1845691611 cites W2057042201 @default.
- W1845691611 cites W2057119719 @default.
- W1845691611 cites W2057121506 @default.
- W1845691611 cites W2059023753 @default.