FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1845752401> ?p ?o ?g. }

• W1845752401 endingPage "1075" @default.
• W1845752401 startingPage "1065" @default.
• W1845752401 abstract "Severe air pollution exposures produce systemic, respiratory, myocardial, and brain inflammation and Alzheimer's disease (AD) hallmarks in clinically healthy children. We tested whether hippocampal metabolite ratios are associated with contrasting levels of air pollution, APOE, and body mass index (BMI) in paired healthy children and one parent sharing the same APOE alleles. We used 1H-MRS to interrogate bilateral hippocampal single-voxel in 57 children (12.45 ± 3.4 years) and their 48 parents (37.5 ± 6.78 years) from a low pollution city versus Mexico City (MC). NAA/Cr, Cho/Cr, and mI/Cr metabolite ratios were analyzed. The right hippocampus NAA/Cr ratio was significantly different between cohorts (p = 0.007). The NAA/Cr ratio in right hippocampus in controls versus APOE ɛ4 MC children and in left hippocampus in MC APOE ɛ4 parents versus their children was significantly different after adjusting for age, gender, and BMI (p = 0.027 and 0.01, respectively). The NAA/Cr ratio is considered reflective of neuronal density/functional integrity/loss of synapses/higher pTau burden, thus a significant decrease in hippocampal NAA/Cr ratios may constitute a spectral marker of early neurodegeneration in young urbanites. Decreases in NAA/Cr correlate well with cognitive function, behavioral symptoms, and dementia severity; thus, since the progression of AD starts decades before clinical diagnosis, our findings support the hypothesis that under chronic exposures to fine particulate matter and ozone above the standards, neurodegenerative processes start in childhood and APOE ɛ4 carriers are at higher risk. Gene and environmental factors are critical in the development of AD and the identification and neuroprotection of young urbanites at high risk must become a public health priority." @default.
• W1845752401 created "2016-06-24" @default.
• W1845752401 creator A5006302877 @default.
• W1845752401 creator A5017464998 @default.
• W1845752401 creator A5036064445 @default.
• W1845752401 creator A5037744432 @default.
• W1845752401 creator A5049958295 @default.
• W1845752401 creator A5054181854 @default.
• W1845752401 creator A5063027189 @default.
• W1845752401 creator A5065838160 @default.
• W1845752401 creator A5072706793 @default.
• W1845752401 date "2015-10-27" @default.
• W1845752401 modified "2023-10-02" @default.
• W1845752401 title "A Critical Proton MR Spectroscopy Marker of Alzheimer’s Disease Early Neurodegenerative Change: Low Hippocampal NAA/Cr Ratio Impacts APOE ɛ4 Mexico City Children and Their Parents" @default.
• W1845752401 cites W136814610 @default.
• W1845752401 cites W1536585711 @default.
• W1845752401 cites W1553054099 @default.
• W1845752401 cites W1571725385 @default.
• W1845752401 cites W1963600342 @default.
• W1845752401 cites W1964929724 @default.
• W1845752401 cites W1965336960 @default.
• W1845752401 cites W1970674424 @default.
• W1845752401 cites W1973259717 @default.
• W1845752401 cites W1985504851 @default.
• W1845752401 cites W1986337502 @default.
• W1845752401 cites W1991460309 @default.
• W1845752401 cites W1993023011 @default.
• W1845752401 cites W2008125089 @default.
• W1845752401 cites W2008762660 @default.
• W1845752401 cites W2010354137 @default.
• W1845752401 cites W2015354598 @default.
• W1845752401 cites W2021335075 @default.
• W1845752401 cites W2022076088 @default.
• W1845752401 cites W2023821356 @default.
• W1845752401 cites W2038565815 @default.
• W1845752401 cites W2042343151 @default.
• W1845752401 cites W2050518116 @default.
• W1845752401 cites W2051765035 @default.
• W1845752401 cites W2054163710 @default.
• W1845752401 cites W2055731174 @default.
• W1845752401 cites W2062065980 @default.
• W1845752401 cites W2067617342 @default.
• W1845752401 cites W2069091805 @default.
• W1845752401 cites W2069899696 @default.
• W1845752401 cites W2071956136 @default.
• W1845752401 cites W2074109912 @default.
• W1845752401 cites W2081533023 @default.
• W1845752401 cites W2082235350 @default.
• W1845752401 cites W2082505510 @default.
• W1845752401 cites W2093642395 @default.
• W1845752401 cites W2094288240 @default.
• W1845752401 cites W2097844974 @default.
• W1845752401 cites W2102118295 @default.
• W1845752401 cites W2102296802 @default.
• W1845752401 cites W2106721416 @default.
• W1845752401 cites W2115094271 @default.
• W1845752401 cites W2117839560 @default.
• W1845752401 cites W2118226607 @default.
• W1845752401 cites W2118975025 @default.
• W1845752401 cites W2121583475 @default.
• W1845752401 cites W2123204955 @default.
• W1845752401 cites W2123854635 @default.
• W1845752401 cites W2124697836 @default.
• W1845752401 cites W2125782074 @default.
• W1845752401 cites W2126356344 @default.
• W1845752401 cites W2128903550 @default.
• W1845752401 cites W2130831435 @default.
• W1845752401 cites W2131744811 @default.
• W1845752401 cites W2133862271 @default.
• W1845752401 cites W2141640941 @default.
• W1845752401 cites W2145858412 @default.
• W1845752401 cites W2154212660 @default.
• W1845752401 cites W2155017387 @default.
• W1845752401 cites W2155962758 @default.
• W1845752401 cites W2157803319 @default.
• W1845752401 cites W2159818759 @default.
• W1845752401 cites W2160816909 @default.
• W1845752401 cites W2161298894 @default.
• W1845752401 cites W2161576159 @default.
• W1845752401 cites W2162692469 @default.
• W1845752401 cites W2165019930 @default.
• W1845752401 cites W2166968142 @default.
• W1845752401 cites W2167762661 @default.
• W1845752401 cites W2168269899 @default.
• W1845752401 cites W2169281592 @default.
• W1845752401 cites W2171812510 @default.
• W1845752401 cites W634619152 @default.
• W1845752401 cites W66882421 @default.
• W1845752401 doi "https://doi.org/10.3233/jad-150415" @default.
• W1845752401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26402110" @default.
• W1845752401 hasPublicationYear "2015" @default.
• W1845752401 type Work @default.
• W1845752401 sameAs 1845752401 @default.
• W1845752401 citedByCount "40" @default.
• W1845752401 countsByYear W18457524012016 @default.
• W1845752401 countsByYear W18457524012017 @default.
• W1845752401 countsByYear W18457524012018 @default.
• W1845752401 countsByYear W18457524012019 @default.

• next