FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1846268358> ?p ?o ?g. }

• W1846268358 endingPage "1050" @default.
• W1846268358 startingPage "1036" @default.
• W1846268358 abstract "While much is known about the biosynthesis of secondary metabolites by filamentous fungi their biological role is often less clear. The assumption is these pathways have adaptive value to the organism but often the evidence to support this role is lacking. We provide the first genetic evidence that the fungal produced secondary metabolite, peramine, protects a host plant from insect herbivory. Peramine is a potent insect feeding deterrent synthesized by Epichloë/Neotyphodium mutualistic endophytes in association with their grass hosts. The structure of peramine, a pyrrolopyrazine, suggests that it is the product of a reaction catalysed by a two-module non-ribosomal peptide synthetase (NRPS). Candidate sequences for a peramine synthetase were amplified by reverse transcription polymerase chain reaction. Four unique NRPS products were identified, two of which were preferentially expressed in planta. One of these hybridized to known peramine producing strains. This clone was used to isolate an Epichloë festucae cosmid that contained a two-module NRPS, designated perA. Nine additional genes, which show striking conservation of microsynteny with Fusarium graminearum and other fungal genomes, were identified on the perA-containing cosmid. Associations between perennial ryegrass and an E. festucae mutant deleted for perA lack detectable levels of peramine. A wild-type copy of perA complemented the deletion mutant, confirming that perA is a NRPS required for peramine biosynthesis. In a choice bioassay, plant material containing the perA mutant was as susceptible to Argentine stem weevil (ASW) (Listronotus bonariensis) feeding damage as endophyte-free plants confirming that peramine is the E. festucae metabolite responsible for ASW feeding deterrent activity." @default.
• W1846268358 created "2016-06-24" @default.
• W1846268358 creator A5011774091 @default.
• W1846268358 creator A5026970859 @default.
• W1846268358 creator A5038231748 @default.
• W1846268358 creator A5069247546 @default.
• W1846268358 creator A5085346682 @default.
• W1846268358 date "2005-07-05" @default.
• W1846268358 modified "2023-10-03" @default.
• W1846268358 title "A symbiosis expressed non-ribosomal peptide synthetase from a mutualistic fungal endophyte of perennial ryegrass confers protection to the symbiotum from insect herbivory" @default.
• W1846268358 cites W1518711517 @default.
• W1846268358 cites W1538215925 @default.
• W1846268358 cites W1553105449 @default.
• W1846268358 cites W1620638053 @default.
• W1846268358 cites W1954570390 @default.
• W1846268358 cites W1963919776 @default.
• W1846268358 cites W1964862470 @default.
• W1846268358 cites W1965087628 @default.
• W1846268358 cites W1971119753 @default.
• W1846268358 cites W1971511760 @default.
• W1846268358 cites W1977693942 @default.
• W1846268358 cites W1978450161 @default.
• W1846268358 cites W1982635261 @default.
• W1846268358 cites W1986657721 @default.
• W1846268358 cites W1995315606 @default.
• W1846268358 cites W1997503637 @default.
• W1846268358 cites W1999690668 @default.
• W1846268358 cites W2011433491 @default.
• W1846268358 cites W2015292449 @default.
• W1846268358 cites W2018990299 @default.
• W1846268358 cites W2021865548 @default.
• W1846268358 cites W2023039216 @default.
• W1846268358 cites W2023320945 @default.
• W1846268358 cites W2027807422 @default.
• W1846268358 cites W2033152875 @default.
• W1846268358 cites W2036631423 @default.
• W1846268358 cites W2036852973 @default.
• W1846268358 cites W2038847518 @default.
• W1846268358 cites W2041208398 @default.
• W1846268358 cites W2041254003 @default.
• W1846268358 cites W2047985247 @default.
• W1846268358 cites W2052553858 @default.
• W1846268358 cites W2055043387 @default.
• W1846268358 cites W2057766174 @default.
• W1846268358 cites W2057850803 @default.
• W1846268358 cites W2059977778 @default.
• W1846268358 cites W2063450941 @default.
• W1846268358 cites W2064831811 @default.
• W1846268358 cites W2067058097 @default.
• W1846268358 cites W2067834514 @default.
• W1846268358 cites W2068652099 @default.
• W1846268358 cites W2080895748 @default.
• W1846268358 cites W2087907807 @default.
• W1846268358 cites W2089664448 @default.
• W1846268358 cites W2092202092 @default.
• W1846268358 cites W2092922394 @default.
• W1846268358 cites W2097321270 @default.
• W1846268358 cites W2097984054 @default.
• W1846268358 cites W2106882534 @default.
• W1846268358 cites W2110199548 @default.
• W1846268358 cites W2114839447 @default.
• W1846268358 cites W2116909696 @default.
• W1846268358 cites W2117014455 @default.
• W1846268358 cites W2129831021 @default.
• W1846268358 cites W2132164598 @default.
• W1846268358 cites W2132566970 @default.
• W1846268358 cites W2138270253 @default.
• W1846268358 cites W2140059688 @default.
• W1846268358 cites W2140198147 @default.
• W1846268358 cites W2143417865 @default.
• W1846268358 cites W2153283265 @default.
• W1846268358 cites W2157262350 @default.
• W1846268358 cites W2158714788 @default.
• W1846268358 cites W2331553798 @default.
• W1846268358 cites W2479736110 @default.
• W1846268358 cites W371924464 @default.
• W1846268358 doi "https://doi.org/10.1111/j.1365-2958.2005.04747.x" @default.
• W1846268358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16091042" @default.
• W1846268358 hasPublicationYear "2005" @default.
• W1846268358 type Work @default.
• W1846268358 sameAs 1846268358 @default.
• W1846268358 citedByCount "273" @default.
• W1846268358 countsByYear W18462683582012 @default.
• W1846268358 countsByYear W18462683582013 @default.
• W1846268358 countsByYear W18462683582014 @default.
• W1846268358 countsByYear W18462683582015 @default.
• W1846268358 countsByYear W18462683582016 @default.
• W1846268358 countsByYear W18462683582017 @default.
• W1846268358 countsByYear W18462683582018 @default.
• W1846268358 countsByYear W18462683582019 @default.
• W1846268358 countsByYear W18462683582020 @default.
• W1846268358 countsByYear W18462683582021 @default.
• W1846268358 countsByYear W18462683582022 @default.
• W1846268358 countsByYear W18462683582023 @default.
• W1846268358 crossrefType "journal-article" @default.
• W1846268358 hasAuthorship W1846268358A5011774091 @default.
• W1846268358 hasAuthorship W1846268358A5026970859 @default.
• W1846268358 hasAuthorship W1846268358A5038231748 @default.

• next