Matches in SemOpenAlex for { <https://semopenalex.org/work/W1846366113> ?p ?o ?g. }
- W1846366113 endingPage "174" @default.
- W1846366113 startingPage "166" @default.
- W1846366113 abstract "Planar cell polarity (PCP) in the Drosophila eye is generated when immature ommatidial preclusters acquire opposite chirality in the dorsal and ventral halves of the eye imaginal disc and rotate 90 ° toward the equator. The scabrous (sca) gene is involved in R8 differentiation and in the correct spacing of ommatidial clusters in eye imaginal discs, but it was also suggested to be required during ommatidial rotation. However, no clear relationships between sca and other genes involved in the process were established.To explore the role of Sca in PCP establishment, we performed an RNAi-based modifier genetic screen using the rough eye phenotype of sca-overexpressing flies. We found that sca overexpression mainly affects R3/R4 cell specification as it was reported in Notch mutants. Of the 86 modifiers identified in the screen, genes encoding components of Notch signaling and proteins involved in intracellular transport were of particular interest.These and other results obtained with a reporter line of Notch activity indicate that sca overexpression antagonizes Notch signaling in the Drosophila eye, and are inconsistent with Sca being an ommatidial rotation-specific factor. We also found that microtubule motors and other proteins involved in intracellular transport are related with Sca function." @default.
- W1846366113 created "2016-06-24" @default.
- W1846366113 creator A5034821632 @default.
- W1846366113 creator A5054725033 @default.
- W1846366113 creator A5067398016 @default.
- W1846366113 creator A5081538653 @default.
- W1846366113 creator A5088823515 @default.
- W1846366113 date "2015-11-22" @default.
- W1846366113 modified "2023-10-15" @default.
- W1846366113 title "Scabrous overexpression in the eye affects R3/R4 cell fate specification and inhibits notch signaling" @default.
- W1846366113 cites W1508305548 @default.
- W1846366113 cites W1545756296 @default.
- W1846366113 cites W1639000772 @default.
- W1846366113 cites W171537913 @default.
- W1846366113 cites W1870170793 @default.
- W1846366113 cites W191629038 @default.
- W1846366113 cites W1971326877 @default.
- W1846366113 cites W1975085437 @default.
- W1846366113 cites W1975803734 @default.
- W1846366113 cites W1975979806 @default.
- W1846366113 cites W1977962361 @default.
- W1846366113 cites W1981116235 @default.
- W1846366113 cites W1989382065 @default.
- W1846366113 cites W2000520401 @default.
- W1846366113 cites W2000744593 @default.
- W1846366113 cites W2006679866 @default.
- W1846366113 cites W2008739015 @default.
- W1846366113 cites W2015171213 @default.
- W1846366113 cites W2019482668 @default.
- W1846366113 cites W2019578272 @default.
- W1846366113 cites W2026167463 @default.
- W1846366113 cites W2029567239 @default.
- W1846366113 cites W2031258074 @default.
- W1846366113 cites W2037524379 @default.
- W1846366113 cites W2045590006 @default.
- W1846366113 cites W2046720103 @default.
- W1846366113 cites W2048027045 @default.
- W1846366113 cites W2050526112 @default.
- W1846366113 cites W2051202415 @default.
- W1846366113 cites W2052309340 @default.
- W1846366113 cites W2068806468 @default.
- W1846366113 cites W2071199606 @default.
- W1846366113 cites W2073280734 @default.
- W1846366113 cites W2075961706 @default.
- W1846366113 cites W2078968247 @default.
- W1846366113 cites W2086249507 @default.
- W1846366113 cites W2087658519 @default.
- W1846366113 cites W2089492454 @default.
- W1846366113 cites W2095581840 @default.
- W1846366113 cites W2096526911 @default.
- W1846366113 cites W2102625414 @default.
- W1846366113 cites W2125545718 @default.
- W1846366113 cites W2131783587 @default.
- W1846366113 cites W2142792909 @default.
- W1846366113 cites W2151140509 @default.
- W1846366113 cites W2154861644 @default.
- W1846366113 cites W2157467920 @default.
- W1846366113 cites W2166931568 @default.
- W1846366113 cites W2167082284 @default.
- W1846366113 doi "https://doi.org/10.1002/dvdy.24362" @default.
- W1846366113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26505171" @default.
- W1846366113 hasPublicationYear "2015" @default.
- W1846366113 type Work @default.
- W1846366113 sameAs 1846366113 @default.
- W1846366113 citedByCount "4" @default.
- W1846366113 countsByYear W18463661132018 @default.
- W1846366113 countsByYear W18463661132021 @default.
- W1846366113 countsByYear W18463661132022 @default.
- W1846366113 crossrefType "journal-article" @default.
- W1846366113 hasAuthorship W1846366113A5034821632 @default.
- W1846366113 hasAuthorship W1846366113A5054725033 @default.
- W1846366113 hasAuthorship W1846366113A5067398016 @default.
- W1846366113 hasAuthorship W1846366113A5081538653 @default.
- W1846366113 hasAuthorship W1846366113A5088823515 @default.
- W1846366113 hasBestOaLocation W18463661131 @default.
- W1846366113 hasConcept C104317684 @default.
- W1846366113 hasConcept C111368507 @default.
- W1846366113 hasConcept C114696181 @default.
- W1846366113 hasConcept C120665830 @default.
- W1846366113 hasConcept C121332964 @default.
- W1846366113 hasConcept C127313418 @default.
- W1846366113 hasConcept C127716648 @default.
- W1846366113 hasConcept C143065580 @default.
- W1846366113 hasConcept C161879069 @default.
- W1846366113 hasConcept C163952510 @default.
- W1846366113 hasConcept C166703698 @default.
- W1846366113 hasConcept C202769670 @default.
- W1846366113 hasConcept C203635412 @default.
- W1846366113 hasConcept C207177822 @default.
- W1846366113 hasConcept C2909722775 @default.
- W1846366113 hasConcept C50213807 @default.
- W1846366113 hasConcept C54355233 @default.
- W1846366113 hasConcept C62478195 @default.
- W1846366113 hasConcept C67705224 @default.
- W1846366113 hasConcept C79879829 @default.
- W1846366113 hasConcept C86339819 @default.
- W1846366113 hasConcept C86803240 @default.
- W1846366113 hasConcept C91986751 @default.