FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1846384114> ?p ?o ?g. }

• W1846384114 endingPage "622" @default.
• W1846384114 startingPage "616" @default.
• W1846384114 abstract "Dietary copper (Cu) restriction leads to cardiac hypertrophy and failure in mice, and Cu repletion (CuR) reverses the hypertrophy and prevents the transition to heart failure. The present study was undertaken to determine changes in myocardial gene expression involved in Cu deficient (CuD) cardiomyopathy and its reversal by CuR. Analysis was performed on three groups of mice: 4-week-old CuD mice that exhibited signs of cardiac failure, their age-matched copper-adequate (CuA) controls, and the CuD mice that were re-fed adequate Cu for 2 weeks. Total RNA was isolated from hearts and subjected to cDNA micro-array and real-time reverse transcription-polymerase chain reaction analysis. Dietary CuD caused a decrease in cardiac mRNA of beta-MHC, L-type Ca(2+) channel, K-dependent NCX, MMP-2, -8, and -13, NF-kappaB, and VEGF. The mRNA levels of ET-1, TGF-beta, TNF-alpha, and procollagen-I-alpha1 and III-alpha1 were increased in the CuD cardiac tissue. Copper repletion resulted in cardiac mRNA levels of most of the genes examined returning to control levels, although the K-dependent NCX and MMP-2 values did not reach those of the CuA control. In addition, CuR caused an increase in beta-MHC, L-type Ca(2+)channel, MMP-13 to levels surpassing those of CuA control, and a decrease in ET-1, and TNF-alpha mRNA levels. In summary, changes in gene expression of elements involved in contractility, Ca(2+) cycling, and inflammation and fibrosis may account for the altered cardiac function found in CuD mice. The return to normal cardiac function by CuR may be a result of the favorable regression in gene expression of these critical components in myocardial tissue." @default.
• W1846384114 created "2016-06-24" @default.
• W1846384114 creator A5026799694 @default.
• W1846384114 creator A5038204854 @default.
• W1846384114 creator A5076308694 @default.
• W1846384114 creator A5087783543 @default.
• W1846384114 date "2004-07-01" @default.
• W1846384114 modified "2023-09-27" @default.
• W1846384114 title "Dietary Copper Restriction-Induced Changes in Myocardial Gene Expression and the Effect of Copper Repletion" @default.
• W1846384114 cites W1753468142 @default.
• W1846384114 cites W1826549280 @default.
• W1846384114 cites W1831301545 @default.
• W1846384114 cites W1864912446 @default.
• W1846384114 cites W1966383892 @default.
• W1846384114 cites W1971702213 @default.
• W1846384114 cites W1977152294 @default.
• W1846384114 cites W1977158361 @default.
• W1846384114 cites W1985975597 @default.
• W1846384114 cites W1993070915 @default.
• W1846384114 cites W2001244884 @default.
• W1846384114 cites W2003007249 @default.
• W1846384114 cites W2007396515 @default.
• W1846384114 cites W2010125004 @default.
• W1846384114 cites W2016255823 @default.
• W1846384114 cites W2019435811 @default.
• W1846384114 cites W2023591835 @default.
• W1846384114 cites W2026392970 @default.
• W1846384114 cites W2053338918 @default.
• W1846384114 cites W2056865036 @default.
• W1846384114 cites W2069585529 @default.
• W1846384114 cites W2077503940 @default.
• W1846384114 cites W2079697827 @default.
• W1846384114 cites W2092883874 @default.
• W1846384114 cites W2101377455 @default.
• W1846384114 cites W2110787501 @default.
• W1846384114 cites W2119853757 @default.
• W1846384114 cites W2121708608 @default.
• W1846384114 cites W2122557945 @default.
• W1846384114 cites W2122568878 @default.
• W1846384114 cites W2129391292 @default.
• W1846384114 cites W2129439677 @default.
• W1846384114 cites W2140031274 @default.
• W1846384114 cites W2333620865 @default.
• W1846384114 cites W2411195788 @default.
• W1846384114 doi "https://doi.org/10.1177/153537020422900705" @default.
• W1846384114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15229355" @default.
• W1846384114 hasPublicationYear "2004" @default.
• W1846384114 type Work @default.
• W1846384114 sameAs 1846384114 @default.
• W1846384114 citedByCount "38" @default.
• W1846384114 countsByYear W18463841142012 @default.
• W1846384114 countsByYear W18463841142013 @default.
• W1846384114 countsByYear W18463841142015 @default.
• W1846384114 countsByYear W18463841142016 @default.
• W1846384114 countsByYear W18463841142017 @default.
• W1846384114 countsByYear W18463841142018 @default.
• W1846384114 countsByYear W18463841142020 @default.
• W1846384114 countsByYear W18463841142021 @default.
• W1846384114 countsByYear W18463841142022 @default.
• W1846384114 countsByYear W18463841142023 @default.
• W1846384114 crossrefType "journal-article" @default.
• W1846384114 hasAuthorship W1846384114A5026799694 @default.
• W1846384114 hasAuthorship W1846384114A5038204854 @default.
• W1846384114 hasAuthorship W1846384114A5076308694 @default.
• W1846384114 hasAuthorship W1846384114A5087783543 @default.
• W1846384114 hasConcept C104317684 @default.
• W1846384114 hasConcept C105580179 @default.
• W1846384114 hasConcept C111566952 @default.
• W1846384114 hasConcept C126322002 @default.
• W1846384114 hasConcept C134018914 @default.
• W1846384114 hasConcept C150194340 @default.
• W1846384114 hasConcept C167414201 @default.
• W1846384114 hasConcept C178790620 @default.
• W1846384114 hasConcept C185592680 @default.
• W1846384114 hasConcept C2777106986 @default.
• W1846384114 hasConcept C2778198053 @default.
• W1846384114 hasConcept C2778797674 @default.
• W1846384114 hasConcept C39133596 @default.
• W1846384114 hasConcept C544778455 @default.
• W1846384114 hasConcept C55493867 @default.
• W1846384114 hasConcept C71924100 @default.
• W1846384114 hasConceptScore W1846384114C104317684 @default.
• W1846384114 hasConceptScore W1846384114C105580179 @default.
• W1846384114 hasConceptScore W1846384114C111566952 @default.
• W1846384114 hasConceptScore W1846384114C126322002 @default.
• W1846384114 hasConceptScore W1846384114C134018914 @default.
• W1846384114 hasConceptScore W1846384114C150194340 @default.
• W1846384114 hasConceptScore W1846384114C167414201 @default.
• W1846384114 hasConceptScore W1846384114C178790620 @default.
• W1846384114 hasConceptScore W1846384114C185592680 @default.
• W1846384114 hasConceptScore W1846384114C2777106986 @default.
• W1846384114 hasConceptScore W1846384114C2778198053 @default.
• W1846384114 hasConceptScore W1846384114C2778797674 @default.
• W1846384114 hasConceptScore W1846384114C39133596 @default.
• W1846384114 hasConceptScore W1846384114C544778455 @default.
• W1846384114 hasConceptScore W1846384114C55493867 @default.
• W1846384114 hasConceptScore W1846384114C71924100 @default.
• W1846384114 hasIssue "7" @default.

• next