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- W184645174 abstract "Publisher Summary This chapter discusses the electronic cell sorting of hemopoietic progenitor cells. The hemopoietic system offers an exciting opportunity for the study of cell commitment, proliferation, and differentiation. Hemopoietic tissues are extremely complex, and hemopoietic cells form an interdependent regulatory network. This necessitates the purification of hemopoietic progenitor cells as well as their molecular regulators to study their interactions. The most primitive cell is a multipotential stem cell capable of extensive self-renewal as well as commitment to each hemopoietic cell lineage. The most commonly used assay for such cells is injection into lethally irradiated recipients where stem cells proliferate and form nodules or colonies in the spleen, hence the term colony-forming unit-spleen. Colony-forming cells, in turn, give rise to committed cells of lesser proliferative potential, termed cluster-forming cells, and finally to recognizable members of each hemopoietic lineage. The special power of fluorescence-activated cell sorting—the ability to assess quantitatively the level of binding of probe on a cell-by-cell basis—has been essential to attempts to purify the rare hemopoietic progenitor cells." @default.
- W184645174 created "2016-06-24" @default.
- W184645174 creator A5069357139 @default.
- W184645174 date "1982-01-01" @default.
- W184645174 modified "2023-10-18" @default.
- W184645174 title "Electronic Cell Sorting of Hemopoietic Progenitor Cells" @default.
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- W184645174 doi "https://doi.org/10.1016/b978-0-12-564501-0.50014-6" @default.
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