FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1846453605> ?p ?o ?g. }

• W1846453605 endingPage "5898" @default.
• W1846453605 startingPage "5890" @default.
• W1846453605 abstract "Human immunodeficiency virus type 1 (HIV-1) infects some cell types which lack CD4, demonstrating that one or more alternative viral receptors exist. One such receptor is galactosylceramide (GalCer), a glycosphingolipid distributed widely in the nervous system and in colonic epithelial cells. Using a liposome flotation assay, we found that the HIV-1 surface glycoprotein, gp120, quantitatively bound to liposomes containing GalCer but not to liposomes containing phospholipids and cholesterol alone. Binding was saturable and was inhibited by preincubating liposomes with anti-GalCer antibodies. We observed less efficient binding of gp120 to liposomes containing lactosylceramide, glucosylceramide, and galactosylsulfate, whereas no binding to liposomes containing mixed gangliosides, psychosine, or sphingomyelin was detected. Binding to GalCer was rapid, largely independent of temperature and pH, and stable to conditions which remove most peripheral membrane proteins. By contrast, gp120 bound to lactosylceramide could be removed by 2 M potassium chloride or 3 M potassium thiocyanate, demonstrating a less stable interaction. Removal of N-linked oligosaccharides on gp120 did not affect binding efficiency. However, as previously observed for CD4 binding, heat denaturation of gp120 prevented binding to GalCer. Finally, binding was critically dependent on the concentration of GalCer in the target membrane, suggesting that binding to glycolipid-rich domains occurs and that GalCer conformation may be important for gp120 recognition." @default.
• W1846453605 created "2016-06-24" @default.
• W1846453605 creator A5010176130 @default.
• W1846453605 creator A5060950962 @default.
• W1846453605 creator A5061965413 @default.
• W1846453605 creator A5081065762 @default.
• W1846453605 date "1994-09-01" @default.
• W1846453605 modified "2023-10-12" @default.
• W1846453605 title "Characterization of human immunodeficiency virus type 1 gp120 binding to liposomes containing galactosylceramide" @default.
• W1846453605 cites W1507272843 @default.
• W1846453605 cites W1522102057 @default.
• W1846453605 cites W1525813631 @default.
• W1846453605 cites W1553466821 @default.
• W1846453605 cites W1560132616 @default.
• W1846453605 cites W1587286994 @default.
• W1846453605 cites W1591950279 @default.
• W1846453605 cites W1594946825 @default.
• W1846453605 cites W1609155991 @default.
• W1846453605 cites W1622684250 @default.
• W1846453605 cites W1723784604 @default.
• W1846453605 cites W1867395634 @default.
• W1846453605 cites W1933773138 @default.
• W1846453605 cites W1937269364 @default.
• W1846453605 cites W1963487395 @default.
• W1846453605 cites W1968262078 @default.
• W1846453605 cites W1969190686 @default.
• W1846453605 cites W1971057735 @default.
• W1846453605 cites W1986159600 @default.
• W1846453605 cites W1988356694 @default.
• W1846453605 cites W1990372134 @default.
• W1846453605 cites W1996024432 @default.
• W1846453605 cites W2005339433 @default.
• W1846453605 cites W2007902265 @default.
• W1846453605 cites W2024152313 @default.
• W1846453605 cites W2035599002 @default.
• W1846453605 cites W2038177103 @default.
• W1846453605 cites W2041165891 @default.
• W1846453605 cites W2047339022 @default.
• W1846453605 cites W2051005349 @default.
• W1846453605 cites W2051359105 @default.
• W1846453605 cites W2053521361 @default.
• W1846453605 cites W2054020690 @default.
• W1846453605 cites W2064631561 @default.
• W1846453605 cites W2071372933 @default.
• W1846453605 cites W2074558188 @default.
• W1846453605 cites W2076082328 @default.
• W1846453605 cites W2077494883 @default.
• W1846453605 cites W2090748249 @default.
• W1846453605 cites W2102973326 @default.
• W1846453605 cites W2107109828 @default.
• W1846453605 cites W2107878486 @default.
• W1846453605 cites W2110114168 @default.
• W1846453605 cites W2113045961 @default.
• W1846453605 cites W2120080045 @default.
• W1846453605 cites W2120345534 @default.
• W1846453605 cites W2133388060 @default.
• W1846453605 cites W2134353518 @default.
• W1846453605 cites W2140819899 @default.
• W1846453605 cites W2156523395 @default.
• W1846453605 cites W2168544954 @default.
• W1846453605 cites W35851371 @default.
• W1846453605 doi "https://doi.org/10.1128/jvi.68.9.5890-5898.1994" @default.
• W1846453605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/236994" @default.
• W1846453605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8057468" @default.
• W1846453605 hasPublicationYear "1994" @default.
• W1846453605 type Work @default.
• W1846453605 sameAs 1846453605 @default.
• W1846453605 citedByCount "70" @default.
• W1846453605 countsByYear W18464536052012 @default.
• W1846453605 countsByYear W18464536052013 @default.
• W1846453605 countsByYear W18464536052014 @default.
• W1846453605 countsByYear W18464536052015 @default.
• W1846453605 countsByYear W18464536052018 @default.
• W1846453605 countsByYear W18464536052023 @default.
• W1846453605 crossrefType "journal-article" @default.
• W1846453605 hasAuthorship W1846453605A5010176130 @default.
• W1846453605 hasAuthorship W1846453605A5060950962 @default.
• W1846453605 hasAuthorship W1846453605A5061965413 @default.
• W1846453605 hasAuthorship W1846453605A5081065762 @default.
• W1846453605 hasBestOaLocation W18464536051 @default.
• W1846453605 hasConcept C108625454 @default.
• W1846453605 hasConcept C170493617 @default.
• W1846453605 hasConcept C185154212 @default.
• W1846453605 hasConcept C22222904 @default.
• W1846453605 hasConcept C2776931407 @default.
• W1846453605 hasConcept C2910328161 @default.
• W1846453605 hasConcept C41625074 @default.
• W1846453605 hasConcept C55493867 @default.
• W1846453605 hasConcept C61322309 @default.
• W1846453605 hasConcept C86803240 @default.
• W1846453605 hasConceptScore W1846453605C108625454 @default.
• W1846453605 hasConceptScore W1846453605C170493617 @default.
• W1846453605 hasConceptScore W1846453605C185154212 @default.
• W1846453605 hasConceptScore W1846453605C22222904 @default.
• W1846453605 hasConceptScore W1846453605C2776931407 @default.
• W1846453605 hasConceptScore W1846453605C2910328161 @default.
• W1846453605 hasConceptScore W1846453605C41625074 @default.
• W1846453605 hasConceptScore W1846453605C55493867 @default.

• next