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- W1846571856 abstract "Abstract Herpetic stromal keratitis (HSK) is a chronic inflammatory process in corneal stroma that results from recurrent HSV type 1 infection. We used the murine model of HSK to demonstrate the importance of the interaction between an inducible T cell costimulatory receptor, 4-1BB, and its ligand, 4-1BB ligand (4-1BBL), in the development of this disease. In BALB/c mice, HSK ordinarily induced by infection with the RE strain of herpes was prevented by blocking 4-1BB/4-1BBL interaction, either by deleting 4-1BB (in mutant 4-1BB−/− mice) or by introducing mAbs against 4-1BBL. The majority of T cells infiltrating the infected corneas were 4-1BB+ activated effector cells that expressed cell surface markers CD44, CD25, and/or CD62L, as well as chemokine receptors CCR1, CCR2, and CCR5, and a limited number of TCR Vβ chains (Vβ8.1/8.2, Vβ8.3, Vβ10b, and Vβ5.1/5.2, in order of abundance). Analysis of cell surface phenotypes showed that the failure to develop HSK in the 4-1BB−/− mice was associated with a reduced expression of CD62L at the time of T cell migration into the corneal stroma." @default.
- W1846571856 created "2016-06-24" @default.
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- W1846571856 date "2003-07-15" @default.
- W1846571856 modified "2023-09-22" @default.
- W1846571856 title "Blocking 4-1BB/4-1BB Ligand Interactions Prevents Herpetic Stromal Keratitis" @default.
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- W1846571856 doi "https://doi.org/10.4049/jimmunol.171.2.576" @default.
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