FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1846616615> ?p ?o ?g. }

• W1846616615 abstract "CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow and their recruitment to sites of injury, as well as affect processes such as cell arrest, survival, and angiogenesis. CXCL12 was long thought to be the sole CXCR4 ligand, but more recently the atypical chemokine macrophage migration inhibitory factor (MIF) was identified as an alternative, non-cognate ligand for CXCR4 and shown to mediate chemotaxis and arrest of CXCR4-expressing T-cells. This has complicated the understanding of CXCR4-mediated signaling and associated biological processes. Compared to CXCL12/CXCR4-induced signaling, only few details are known on MIF/CXCR4-mediated signaling and it remains unclear to which extent MIF and CXCL12 reciprocally influence CXCR4 binding and signaling. Furthermore, the atypical chemokine receptor 3 (ACKR3) (previously CXCR7) has added to the complexity of CXCR4 signaling due to its ability to bind CXCL12 and MIF, and to evoke CXCL12- and MIF-triggered signaling independently of CXCR4. Also, extracellular ubiquitin (eUb) and the viral protein gp120 (HIV) have been reported as CXCR4 ligands, whereas viral chemokine vMIP-II (Herpesvirus) and human β3-defensin (HBD-3) have been identified as CXCR4 antagonists. This review will provide insight into the diversity and inter-connections in the CXCR4 receptor/ligand family. We will discuss signaling pathways initiated by binding of CXCL12 vs. MIF to CXCR4, elaborate on how ACKR3 affects CXCR4 signaling, and summarize biological functions of CXCR4 signaling mediated by CXCL12 or MIF. Also, we will discuss eUb and gp120 as alternative ligands for CXCR4, and describe vMIP-II and HBD-3 as antagonists for CXCR4. Detailed insight into biological effects of CXCR4 signaling und underlying mechanisms, including diversity of CXCR4 ligands and inter-connections with other (chemokine) receptors, is clinically important, as the CXCR4 antagonist AMD3100 has been approved as stem cell mobilizer in specific disease settings." @default.
• W1846616615 created "2016-06-24" @default.
• W1846616615 creator A5000655108 @default.
• W1846616615 creator A5001883769 @default.
• W1846616615 creator A5027388092 @default.
• W1846616615 creator A5059997153 @default.
• W1846616615 creator A5089562986 @default.
• W1846616615 date "2015-08-21" @default.
• W1846616615 modified "2023-09-30" @default.
• W1846616615 title "Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives" @default.
• W1846616615 cites W1481422886 @default.
• W1846616615 cites W1481702625 @default.
• W1846616615 cites W1501260171 @default.
• W1846616615 cites W1532087698 @default.
• W1846616615 cites W1551351100 @default.
• W1846616615 cites W1553619681 @default.
• W1846616615 cites W1564740964 @default.
• W1846616615 cites W161994666 @default.
• W1846616615 cites W1654419898 @default.
• W1846616615 cites W1668963162 @default.
• W1846616615 cites W176885668 @default.
• W1846616615 cites W1895363198 @default.
• W1846616615 cites W1910962331 @default.
• W1846616615 cites W1922502842 @default.
• W1846616615 cites W1922705469 @default.
• W1846616615 cites W1933773138 @default.
• W1846616615 cites W1958554861 @default.
• W1846616615 cites W1963880609 @default.
• W1846616615 cites W1963967499 @default.
• W1846616615 cites W1964057503 @default.
• W1846616615 cites W1964083898 @default.
• W1846616615 cites W1964407094 @default.
• W1846616615 cites W1965498551 @default.
• W1846616615 cites W1966768211 @default.
• W1846616615 cites W1968621198 @default.
• W1846616615 cites W1968952693 @default.
• W1846616615 cites W1970448164 @default.
• W1846616615 cites W1971588558 @default.
• W1846616615 cites W1971874676 @default.
• W1846616615 cites W1972281922 @default.
• W1846616615 cites W1973610607 @default.
• W1846616615 cites W1974132609 @default.
• W1846616615 cites W1974508266 @default.
• W1846616615 cites W1975869862 @default.
• W1846616615 cites W1976411708 @default.
• W1846616615 cites W1977091420 @default.
• W1846616615 cites W1979244891 @default.
• W1846616615 cites W1979408355 @default.
• W1846616615 cites W1980007800 @default.
• W1846616615 cites W1981149366 @default.
• W1846616615 cites W1982861439 @default.
• W1846616615 cites W1983933064 @default.
• W1846616615 cites W1983977485 @default.
• W1846616615 cites W1986837253 @default.
• W1846616615 cites W1987128031 @default.
• W1846616615 cites W1987566026 @default.
• W1846616615 cites W1987600691 @default.
• W1846616615 cites W1987704983 @default.
• W1846616615 cites W1988250064 @default.
• W1846616615 cites W1989035987 @default.
• W1846616615 cites W1989207250 @default.
• W1846616615 cites W1989832114 @default.
• W1846616615 cites W1990461661 @default.
• W1846616615 cites W1991562400 @default.
• W1846616615 cites W1991707658 @default.
• W1846616615 cites W1991962824 @default.
• W1846616615 cites W1993717649 @default.
• W1846616615 cites W1995355944 @default.
• W1846616615 cites W1996016939 @default.
• W1846616615 cites W1997695335 @default.
• W1846616615 cites W1997868017 @default.
• W1846616615 cites W1998203652 @default.
• W1846616615 cites W2000185622 @default.
• W1846616615 cites W2000541661 @default.
• W1846616615 cites W2001013907 @default.
• W1846616615 cites W2002567921 @default.
• W1846616615 cites W2003098831 @default.
• W1846616615 cites W2005522614 @default.
• W1846616615 cites W2005805066 @default.
• W1846616615 cites W2006398427 @default.
• W1846616615 cites W2007286054 @default.
• W1846616615 cites W2007415938 @default.
• W1846616615 cites W2008928946 @default.
• W1846616615 cites W2009021998 @default.
• W1846616615 cites W2009309403 @default.
• W1846616615 cites W2009795125 @default.
• W1846616615 cites W2011474505 @default.
• W1846616615 cites W2011591924 @default.
• W1846616615 cites W2015198542 @default.
• W1846616615 cites W2015439707 @default.
• W1846616615 cites W2016027114 @default.
• W1846616615 cites W2016758546 @default.
• W1846616615 cites W2017936152 @default.
• W1846616615 cites W2019535641 @default.
• W1846616615 cites W2020214100 @default.
• W1846616615 cites W2021193846 @default.
• W1846616615 cites W2021256296 @default.
• W1846616615 cites W2022468880 @default.
• W1846616615 cites W20228888 @default.
• W1846616615 cites W2024659862 @default.

• next