Matches in SemOpenAlex for { <https://semopenalex.org/work/W184667369> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W184667369 endingPage "32" @default.
- W184667369 startingPage "S28" @default.
- W184667369 abstract "Myeloperoxidase (MPO) -anti-neutrophil cytoplasmic autoantibodies (ANCAs) are detected at a high rate in microscopic polyangiitis and renal-limited vasculitis. MPO-ANCA titers are not always reflected in the disease activity. We studied the titer and affinity of MPO-ANCA in sera from patients in relation to vasculitis activity.Blood samples were collected from 27 newly diagnosed or relapsed patients with MPO-ANCA-associated vasculitides. The MPO-ANCA titer was determined by a direct enzyme-linked immunosorbent assay (ELISA) using homogeneously purified human MPO of leukocytes. The MPO-ANCA affinity was expressed as IC50 that was determined by a competitive inhibition method using the ELISA.The MPO-ANCA affinity of 27 sera from 27 patients could be classified into a high-affinity type (14 sera) and a low-affinity type (13 sera). The mean values for IC50 in the two types were 0.15+/-0.06 microg/ml and 0.54+/-0.15 microg/ml, and the difference was statistically significant (p<0.0000000684). Between the two groups of patients divided by the affinity, there were differences in the Birmingham Vasculitis Activity Score (BVAS): and in C-reactive protein (CRP): (p<0.00093 and p<0.00129, respectively). However, the difference in titer was not statistically significant (p<0.0265). The affinity remained steady from the disease onset to remission or relapse.The affinity of MPO-ANCA from patients with MPO-ANCA-associated vasculitides were largely distinguished into a high and a low affinity, irrespective of the level of MPO-ANCA titers, and may be helpful for assessment of vasculitis activity affecting mainly the kidney and the lung." @default.
- W184667369 created "2016-06-24" @default.
- W184667369 creator A5004063676 @default.
- W184667369 creator A5005083194 @default.
- W184667369 creator A5035640137 @default.
- W184667369 creator A5056922895 @default.
- W184667369 creator A5058630840 @default.
- W184667369 creator A5060130752 @default.
- W184667369 creator A5068080142 @default.
- W184667369 creator A5086720997 @default.
- W184667369 creator A5087300715 @default.
- W184667369 date "2010-01-14" @default.
- W184667369 modified "2023-09-25" @default.
- W184667369 title "Two types of myeloperoxidase-antineutrophil cytoplasmic autoantibodies with a high affinity and a low affinity in small vessel vasculitis." @default.
- W184667369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19646343" @default.
- W184667369 hasPublicationYear "2010" @default.
- W184667369 type Work @default.
- W184667369 sameAs 184667369 @default.
- W184667369 citedByCount "12" @default.
- W184667369 countsByYear W1846673692013 @default.
- W184667369 countsByYear W1846673692014 @default.
- W184667369 countsByYear W1846673692016 @default.
- W184667369 countsByYear W1846673692018 @default.
- W184667369 countsByYear W1846673692021 @default.
- W184667369 countsByYear W1846673692022 @default.
- W184667369 countsByYear W1846673692023 @default.
- W184667369 crossrefType "journal-article" @default.
- W184667369 hasAuthorship W184667369A5004063676 @default.
- W184667369 hasAuthorship W184667369A5005083194 @default.
- W184667369 hasAuthorship W184667369A5035640137 @default.
- W184667369 hasAuthorship W184667369A5056922895 @default.
- W184667369 hasAuthorship W184667369A5058630840 @default.
- W184667369 hasAuthorship W184667369A5060130752 @default.
- W184667369 hasAuthorship W184667369A5068080142 @default.
- W184667369 hasAuthorship W184667369A5086720997 @default.
- W184667369 hasAuthorship W184667369A5087300715 @default.
- W184667369 hasConcept C126322002 @default.
- W184667369 hasConcept C142724271 @default.
- W184667369 hasConcept C159654299 @default.
- W184667369 hasConcept C163764329 @default.
- W184667369 hasConcept C203014093 @default.
- W184667369 hasConcept C203565725 @default.
- W184667369 hasConcept C21194631 @default.
- W184667369 hasConcept C24040308 @default.
- W184667369 hasConcept C2776015282 @default.
- W184667369 hasConcept C2776914184 @default.
- W184667369 hasConcept C2778910314 @default.
- W184667369 hasConcept C2779134260 @default.
- W184667369 hasConcept C32611913 @default.
- W184667369 hasConcept C71924100 @default.
- W184667369 hasConcept C90924648 @default.
- W184667369 hasConceptScore W184667369C126322002 @default.
- W184667369 hasConceptScore W184667369C142724271 @default.
- W184667369 hasConceptScore W184667369C159654299 @default.
- W184667369 hasConceptScore W184667369C163764329 @default.
- W184667369 hasConceptScore W184667369C203014093 @default.
- W184667369 hasConceptScore W184667369C203565725 @default.
- W184667369 hasConceptScore W184667369C21194631 @default.
- W184667369 hasConceptScore W184667369C24040308 @default.
- W184667369 hasConceptScore W184667369C2776015282 @default.
- W184667369 hasConceptScore W184667369C2776914184 @default.
- W184667369 hasConceptScore W184667369C2778910314 @default.
- W184667369 hasConceptScore W184667369C2779134260 @default.
- W184667369 hasConceptScore W184667369C32611913 @default.
- W184667369 hasConceptScore W184667369C71924100 @default.
- W184667369 hasConceptScore W184667369C90924648 @default.
- W184667369 hasIssue "1 Suppl 52" @default.
- W184667369 hasLocation W1846673691 @default.
- W184667369 hasOpenAccess W184667369 @default.
- W184667369 hasPrimaryLocation W1846673691 @default.
- W184667369 hasRelatedWork W1984906155 @default.
- W184667369 hasRelatedWork W2025022308 @default.
- W184667369 hasRelatedWork W2031517139 @default.
- W184667369 hasRelatedWork W2037086040 @default.
- W184667369 hasRelatedWork W2043756611 @default.
- W184667369 hasRelatedWork W2050969811 @default.
- W184667369 hasRelatedWork W2067022007 @default.
- W184667369 hasRelatedWork W2085006540 @default.
- W184667369 hasRelatedWork W2101997679 @default.
- W184667369 hasRelatedWork W2104934425 @default.
- W184667369 hasRelatedWork W2151252177 @default.
- W184667369 hasRelatedWork W2350519892 @default.
- W184667369 hasRelatedWork W2357671451 @default.
- W184667369 hasRelatedWork W2370520337 @default.
- W184667369 hasRelatedWork W2376921745 @default.
- W184667369 hasRelatedWork W2387436211 @default.
- W184667369 hasRelatedWork W2391569444 @default.
- W184667369 hasRelatedWork W2911376847 @default.
- W184667369 hasRelatedWork W41835247 @default.
- W184667369 hasRelatedWork W2183752907 @default.
- W184667369 hasVolume "27" @default.
- W184667369 isParatext "false" @default.
- W184667369 isRetracted "false" @default.
- W184667369 magId "184667369" @default.
- W184667369 workType "article" @default.