Matches in SemOpenAlex for { <https://semopenalex.org/work/W1846808436> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1846808436 endingPage "496" @default.
- W1846808436 startingPage "491" @default.
- W1846808436 abstract "Specific pathogen-free B6D2 hybrid mice were infected with high (10(8) cells, intravenous), moderate (10(6) cells, intravenous), and low 10(3) cells, aerogenic) doses of viable BCG Pasteur. The growth of the BCG in the lungs and spleens of the three groups was followed over a 90-day period and correlated with the level of tuberculin hypersensitivity. Spleen cells were harvested from the three groups of mice at increasing time intervals and filtered through nylon wool to remove adherent cells, and the level of blast transformation after exposure to phytohemagglutinin and purified protein derivative was determined. Early in the BCG infection both the high- and the intermediate-dose groups showed enhanced thymidine incorporation by the spleen cell cultures, followed by a profound depression late in the infection. At this time, both groups of mice were anergic to purified protein derivative injected into footpads. Cell mixing studies demonstrated the presence of a population of suppressor cells in the spleens of the anergic animals. The suppressive abilities of these cells would be ablated by treatment with anti-Thy-1 antiserum and complement. The aerogenically infected mice were unresponsive to purified protein derivative but showed no evidence of suppressor T-cells. The lack of tuberculin sensitivity in these mice seemed to be due to a lack of sensitized T-cells in the spleen rather than to active immunosuppression." @default.
- W1846808436 created "2016-06-24" @default.
- W1846808436 creator A5020643486 @default.
- W1846808436 creator A5090235621 @default.
- W1846808436 date "1979-08-01" @default.
- W1846808436 modified "2023-09-26" @default.
- W1846808436 title "Suppressor T-cells in BCG-infected mice" @default.
- W1846808436 cites W1600671496 @default.
- W1846808436 cites W1830670292 @default.
- W1846808436 cites W1863186269 @default.
- W1846808436 cites W1964409827 @default.
- W1846808436 cites W1968974831 @default.
- W1846808436 cites W1995263146 @default.
- W1846808436 cites W2012304906 @default.
- W1846808436 cites W2084093106 @default.
- W1846808436 cites W2105804166 @default.
- W1846808436 cites W2209049088 @default.
- W1846808436 cites W2398728553 @default.
- W1846808436 doi "https://doi.org/10.1128/iai.25.2.491-496.1979" @default.
- W1846808436 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/414479" @default.
- W1846808436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/158567" @default.
- W1846808436 hasPublicationYear "1979" @default.
- W1846808436 type Work @default.
- W1846808436 sameAs 1846808436 @default.
- W1846808436 citedByCount "58" @default.
- W1846808436 crossrefType "journal-article" @default.
- W1846808436 hasAuthorship W1846808436A5020643486 @default.
- W1846808436 hasAuthorship W1846808436A5090235621 @default.
- W1846808436 hasBestOaLocation W18468084361 @default.
- W1846808436 hasConcept C142724271 @default.
- W1846808436 hasConcept C147483822 @default.
- W1846808436 hasConcept C153911025 @default.
- W1846808436 hasConcept C159047783 @default.
- W1846808436 hasConcept C203014093 @default.
- W1846808436 hasConcept C2776090121 @default.
- W1846808436 hasConcept C2776247216 @default.
- W1846808436 hasConcept C2780252810 @default.
- W1846808436 hasConcept C2780931953 @default.
- W1846808436 hasConcept C2781069245 @default.
- W1846808436 hasConcept C2908647359 @default.
- W1846808436 hasConcept C71924100 @default.
- W1846808436 hasConcept C86803240 @default.
- W1846808436 hasConcept C8891405 @default.
- W1846808436 hasConcept C89423630 @default.
- W1846808436 hasConcept C91523082 @default.
- W1846808436 hasConcept C99454951 @default.
- W1846808436 hasConceptScore W1846808436C142724271 @default.
- W1846808436 hasConceptScore W1846808436C147483822 @default.
- W1846808436 hasConceptScore W1846808436C153911025 @default.
- W1846808436 hasConceptScore W1846808436C159047783 @default.
- W1846808436 hasConceptScore W1846808436C203014093 @default.
- W1846808436 hasConceptScore W1846808436C2776090121 @default.
- W1846808436 hasConceptScore W1846808436C2776247216 @default.
- W1846808436 hasConceptScore W1846808436C2780252810 @default.
- W1846808436 hasConceptScore W1846808436C2780931953 @default.
- W1846808436 hasConceptScore W1846808436C2781069245 @default.
- W1846808436 hasConceptScore W1846808436C2908647359 @default.
- W1846808436 hasConceptScore W1846808436C71924100 @default.
- W1846808436 hasConceptScore W1846808436C86803240 @default.
- W1846808436 hasConceptScore W1846808436C8891405 @default.
- W1846808436 hasConceptScore W1846808436C89423630 @default.
- W1846808436 hasConceptScore W1846808436C91523082 @default.
- W1846808436 hasConceptScore W1846808436C99454951 @default.
- W1846808436 hasIssue "2" @default.
- W1846808436 hasLocation W18468084361 @default.
- W1846808436 hasLocation W18468084362 @default.
- W1846808436 hasLocation W18468084363 @default.
- W1846808436 hasOpenAccess W1846808436 @default.
- W1846808436 hasPrimaryLocation W18468084361 @default.
- W1846808436 hasRelatedWork W1973692620 @default.
- W1846808436 hasRelatedWork W2006557190 @default.
- W1846808436 hasRelatedWork W2021248145 @default.
- W1846808436 hasRelatedWork W2036107469 @default.
- W1846808436 hasRelatedWork W2081358646 @default.
- W1846808436 hasRelatedWork W2141965224 @default.
- W1846808436 hasRelatedWork W2220102944 @default.
- W1846808436 hasRelatedWork W2374317970 @default.
- W1846808436 hasRelatedWork W3200647722 @default.
- W1846808436 hasRelatedWork W2781693618 @default.
- W1846808436 hasVolume "25" @default.
- W1846808436 isParatext "false" @default.
- W1846808436 isRetracted "false" @default.
- W1846808436 magId "1846808436" @default.
- W1846808436 workType "article" @default.