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- W1846880010 abstract "The use of membrane separation under the conditions of diafiltration on hollow fiber A66-50DR after acidsaline sedimentation of diphtheria toxoid increased its immunogenicity 1. 8 fold due the elimination of low-molecular admixtures having immunosuppressive activity. For the first time the method of obtaining the highly immunogenic preparation of diphtheria vaccine bymeans of single-stage diafiltration on the same fiber without the stage of acid-saline sedimentation was described; this preparation was found to have considerable of high-molecular fraction with immunostimulating bacterial components. The preparation of tetanus toxoid obtained by the method of acid-saline sedimentanion could be made completely free of low-molecular admixtures with the help of diafiltration on membrane ODE-100, which increased the specific activity of the preparation 1,3 fold. The final products of the toxoidation of tetanus toxoid, obtained as a result of acid-saline sedimentation, single-stage membrane separation and their combined use were noted to differ in their molecular weight parameters. Various membranes having the same cut-off were found to have different separation capacity, which shoud be taken into consideration in the choice of membranes. (Med. Immunol., 2002. vol. 4, N 4-5, pp 619-624)" @default.
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- W1846880010 date "2002-01-01" @default.
- W1846880010 modified "2023-09-27" @default.
- W1846880010 title "Повышение иммуногенности дифтерийной вакцины и совершенствование столбнячного анатоксина с помощью мембранного разделения" @default.
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