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• W1847270645 endingPage "3427" @default.
• W1847270645 startingPage "3422" @default.
• W1847270645 abstract "There is growing interest in the fundamental roles that B cells may play in regulating immune responses. Emerging animal studies point to an important contribution of B cell effector cytokines to immune modulation, yet little is known about the factors regulating such cytokine production. We report that the profile of human B cell cytokine production is context dependent, being critically influenced by the balance of signals through the B cell receptor and CD40. B cells appropriately stimulated by sequential B cell receptor and CD40 stimulation proliferate and secrete TNF-alpha, lymphotoxin, and IL-6, which can act not only as autocrine growth and differentiation factors, but also serve to amplify the ongoing immune response. In contrast, CD40 stimulation alone, a mimic of a B cell receiving bystander T cell help in the absence of specific Ag recognition, induces negligible proinflammatory cytokines, but significant production of IL-10 that serves to suppress inappropriate immune responses. We thus describe a novel paradigm of reciprocal regulation of B cell effector cytokines, and ascribe active roles for human B cells in either promoting or suppressing local immune responses through context-dependent cytokine production." @default.
• W1847270645 created "2016-06-24" @default.
• W1847270645 creator A5077310868 @default.
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• W1847270645 date "2004-03-15" @default.
• W1847270645 modified "2023-10-16" @default.
• W1847270645 title "Distinct Profiles of Human B Cell Effector Cytokines: A Role in Immune Regulation?" @default.
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• W1847270645 doi "https://doi.org/10.4049/jimmunol.172.6.3422" @default.
• W1847270645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15004141" @default.
• W1847270645 hasPublicationYear "2004" @default.
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