Matches in SemOpenAlex for { <https://semopenalex.org/work/W1847611437> ?p ?o ?g. }
- W1847611437 abstract "The chronically instrumented pregnant sheep has been used as a model of human fetal development and responses to pathophysiologic stimuli such as endotoxins, bacteria, umbilical cord occlusions, hypoxia and various pharmacological treatments. The life-saving clinical practices of glucocorticoid treatment in fetuses at risk of premature birth and the therapeutic hypothermia have been developed in this model. This is due to the unique amenability of the non-anesthetized fetal sheep to the surgical placement and maintenance of catheters and electrodes, allowing repetitive blood sampling, substance injection, recording of bioelectrical activity, application of electric stimulation and in vivo organ imaging. Here we describe the surgical instrumentation procedure required to achieve a stable chronically instrumented non-anesthetized fetal sheep model including characterization of the post-operative recovery from blood gas, metabolic and inflammation standpoints." @default.
- W1847611437 created "2016-06-24" @default.
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- W1847611437 date "2015-10-25" @default.
- W1847611437 modified "2023-10-17" @default.
- W1847611437 title "Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings" @default.
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- W1847611437 doi "https://doi.org/10.3791/52581" @default.
- W1847611437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4692673" @default.
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- W1847611437 hasPublicationYear "2015" @default.
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