FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1847670392> ?p ?o ?g. }

• W1847670392 endingPage "307" @default.
• W1847670392 startingPage "297" @default.
• W1847670392 abstract "Variation in longevity in natural populations is attributable to the segregation of multiple interacting loci, whose effects are sensitive to the environment. Although there has been considerable recent progress towards understanding the environmental factors and genetic pathways that regulate lifespan, little is known about the genes causing naturally occurring variation in longevity. Previously, we used deficiency complementation mapping to map two closely linked quantitative trait loci (QTL) causing female-specific variation in longevity between the Oregon (Ore) and 2b strains of Drosophila melanogaster to 35B9-C3 and 35C3 on the second chromosome. The 35B9-C3 QTL encompasses a 50-kb region including four genes, for one of which, shuttle craft (stc), mutations have been generated. The 35C3 QTL localizes to a 200-kb interval with 15 genes, including three genes for which mutations exist (reduced (rd), guftagu (gft) and ms(2)35Ci). Here, we report quantitative complementation tests to mutations at these four positional candidate genes, and show that ms(2)35Ci and stc are novel candidate quantitative trait genes affecting variation in Drosophila longevity. Complementation tests with stc alleles reveal sex- and allele-specific failure to complement, and complementation effects are dependent on the genetic background, indicating considerable epistasis for lifespan. In addition, a homozygous viable stc allele has a sex-specific effect on lifespan. stc encodes an RNA polymerase II transcription factor, and is an attractive candidate gene for the regulation of longevity and variation in longevity, because it is required for motoneuron development and is expressed throughout development. Quantitative genetic analysis of naturally occurring variants with subtle effects on lifespan can identify novel candidate genes and pathways important in the regulation of longevity." @default.
• W1847670392 created "2016-06-24" @default.
• W1847670392 creator A5016662836 @default.
• W1847670392 creator A5059714243 @default.
• W1847670392 creator A5066599605 @default.
• W1847670392 date "2004-09-02" @default.
• W1847670392 modified "2023-10-12" @default.
• W1847670392 title "Shuttle craft: a candidate quantitative trait gene for Drosophila lifespan" @default.
• W1847670392 cites W1488265246 @default.
• W1847670392 cites W1547256603 @default.
• W1847670392 cites W1583148430 @default.
• W1847670392 cites W1587592813 @default.
• W1847670392 cites W1598326569 @default.
• W1847670392 cites W1812816875 @default.
• W1847670392 cites W1838763289 @default.
• W1847670392 cites W1894443853 @default.
• W1847670392 cites W1907035214 @default.
• W1847670392 cites W1913977587 @default.
• W1847670392 cites W1918351153 @default.
• W1847670392 cites W1925964606 @default.
• W1847670392 cites W1931233112 @default.
• W1847670392 cites W1940527306 @default.
• W1847670392 cites W1940904808 @default.
• W1847670392 cites W1948123902 @default.
• W1847670392 cites W1958121461 @default.
• W1847670392 cites W1968011428 @default.
• W1847670392 cites W1972549586 @default.
• W1847670392 cites W1973312959 @default.
• W1847670392 cites W1979450683 @default.
• W1847670392 cites W1980251469 @default.
• W1847670392 cites W1980333298 @default.
• W1847670392 cites W1985425785 @default.
• W1847670392 cites W1987738803 @default.
• W1847670392 cites W1988757966 @default.
• W1847670392 cites W1990276200 @default.
• W1847670392 cites W1993490928 @default.
• W1847670392 cites W1997172163 @default.
• W1847670392 cites W2002176403 @default.
• W1847670392 cites W2002364151 @default.
• W1847670392 cites W2002622198 @default.
• W1847670392 cites W2009688381 @default.
• W1847670392 cites W2015606540 @default.
• W1847670392 cites W2020423636 @default.
• W1847670392 cites W2026414471 @default.
• W1847670392 cites W2028283967 @default.
• W1847670392 cites W2030155143 @default.
• W1847670392 cites W2041838043 @default.
• W1847670392 cites W2042191084 @default.
• W1847670392 cites W2047683380 @default.
• W1847670392 cites W2048967691 @default.
• W1847670392 cites W2049009766 @default.
• W1847670392 cites W2052722944 @default.
• W1847670392 cites W2062048451 @default.
• W1847670392 cites W2062629127 @default.
• W1847670392 cites W2063098376 @default.
• W1847670392 cites W2066519654 @default.
• W1847670392 cites W2067441678 @default.
• W1847670392 cites W2069988949 @default.
• W1847670392 cites W2072288814 @default.
• W1847670392 cites W2074541325 @default.
• W1847670392 cites W2091432023 @default.
• W1847670392 cites W2097948853 @default.
• W1847670392 cites W2100598897 @default.
• W1847670392 cites W2100831836 @default.
• W1847670392 cites W2103268140 @default.
• W1847670392 cites W2108482850 @default.
• W1847670392 cites W2112733614 @default.
• W1847670392 cites W2113374835 @default.
• W1847670392 cites W2115074336 @default.
• W1847670392 cites W2115658229 @default.
• W1847670392 cites W2126735903 @default.
• W1847670392 cites W2127903162 @default.
• W1847670392 cites W2128285239 @default.
• W1847670392 cites W2129529285 @default.
• W1847670392 cites W2131568036 @default.
• W1847670392 cites W2137048190 @default.
• W1847670392 cites W2139824227 @default.
• W1847670392 cites W2145938384 @default.
• W1847670392 cites W2150830764 @default.
• W1847670392 cites W2155265427 @default.
• W1847670392 cites W2159979637 @default.
• W1847670392 cites W2161597083 @default.
• W1847670392 cites W2165209574 @default.
• W1847670392 cites W2167228645 @default.
• W1847670392 cites W2210074438 @default.
• W1847670392 cites W2299121374 @default.
• W1847670392 cites W2315739973 @default.
• W1847670392 cites W2315751720 @default.
• W1847670392 cites W2335741872 @default.
• W1847670392 cites W4230890976 @default.
• W1847670392 doi "https://doi.org/10.1111/j.1474-9728.2004.00114.x" @default.
• W1847670392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15379853" @default.
• W1847670392 hasPublicationYear "2004" @default.
• W1847670392 type Work @default.
• W1847670392 sameAs 1847670392 @default.
• W1847670392 citedByCount "43" @default.
• W1847670392 countsByYear W18476703922012 @default.
• W1847670392 countsByYear W18476703922013 @default.

• next