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- W1847769555 abstract "•Suppressing AMPK activity in the brain increases energy expenditure via brown fat. •Enhancing AMPK activity in brown adipocytes increases brown fat activity. •Targeting AMPK in brown fat holds therapeutic potential for the treatment of obesity. Novel strategies are needed to reduce the obesity epidemic. One promising strategy is activation of brown adipose tissue (BAT), either via the brain or directly, which increases energy expenditure by combustion of fatty acids (FAs) into heat. The enzyme complex AMP-activated protein kinase (AMPK) is crucially involved in energy metabolism and is highly expressed in both brain and BAT, regulating thermogenesis. As a general rule, BAT activity and energy expenditure are increased either by suppression of AMPK activity in the brain, resulting in enhanced sympathetic outflow towards BAT, or by activation of AMPK in BAT. Targeting AMPK may thus hold therapeutic potential for the treatment of obesity and related disorders. Novel strategies are needed to reduce the obesity epidemic. One promising strategy is activation of brown adipose tissue (BAT), either via the brain or directly, which increases energy expenditure by combustion of fatty acids (FAs) into heat. The enzyme complex AMP-activated protein kinase (AMPK) is crucially involved in energy metabolism and is highly expressed in both brain and BAT, regulating thermogenesis. As a general rule, BAT activity and energy expenditure are increased either by suppression of AMPK activity in the brain, resulting in enhanced sympathetic outflow towards BAT, or by activation of AMPK in BAT. Targeting AMPK may thus hold therapeutic potential for the treatment of obesity and related disorders." @default.
- W1847769555 created "2016-06-24" @default.
- W1847769555 creator A5029380450 @default.
- W1847769555 creator A5031530399 @default.
- W1847769555 creator A5035385427 @default.
- W1847769555 creator A5060123483 @default.
- W1847769555 creator A5062851507 @default.
- W1847769555 date "2015-09-01" @default.
- W1847769555 modified "2023-10-11" @default.
- W1847769555 title "Regulation of brown fat by AMP-activated protein kinase" @default.
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