Matches in SemOpenAlex for { <https://semopenalex.org/work/W1847804829> ?p ?o ?g. }
- W1847804829 endingPage "20671" @default.
- W1847804829 startingPage "20661" @default.
- W1847804829 abstract "Gallbladder carcinoma (GBC) is a rare tumor with a dismal survival rate overall. Hence, there is an urgent need for exploring more specific and sensitive biomarkers for the diagnosis and treatment of GBC. At first, amplified total RNAs from two paired GBC tumors and adjacent non-tumorous tissues (ANTTs) were subjected to RNA sequencing. 161 genes were identified differentially expressed between tumors and ANTTs. Functional enrichment analysis indicated that the up-regulated genes in tumor were primarily associated with signaling molecules and enzyme modulators, and mainly involved in cell cycles and pathways in cancer. Twelve differentially expressed genes (DEGs) were further confirmed in another independent cohort of 35 GBC patients. Expression levels of BIRC5, TK1, TNNT1 and MMP9 were found to be positively related to postoperative relapse. There was also a significant correlation between BIRC5 expression and tumor-node-metastasis (TNM) stage. Besides, we observed a positive correlation between serum CA19-9 concentration and the expression levels of TNNT1, MMP9 and CLIC3. Survival analysis revealed that GBC patients with high TK1 and MMP9 expression levels had worse prognosis. These identified DEGs might not only be promising biomarkers for GBC diagnosis and prognosis, but also expedite the discovery of novel therapeutic strategies." @default.
- W1847804829 created "2016-06-24" @default.
- W1847804829 creator A5029695887 @default.
- W1847804829 creator A5029932798 @default.
- W1847804829 creator A5032561728 @default.
- W1847804829 creator A5046676712 @default.
- W1847804829 creator A5051764626 @default.
- W1847804829 creator A5069522797 @default.
- W1847804829 creator A5078264996 @default.
- W1847804829 creator A5082255460 @default.
- W1847804829 date "2015-04-28" @default.
- W1847804829 modified "2023-10-11" @default.
- W1847804829 title "RNA sequencing reveals differentially expressed genes as potential diagnostic and prognostic indicators of gallbladder carcinoma" @default.
- W1847804829 cites W183838820 @default.
- W1847804829 cites W1964093158 @default.
- W1847804829 cites W1970647693 @default.
- W1847804829 cites W1971576831 @default.
- W1847804829 cites W1973845057 @default.
- W1847804829 cites W1981462833 @default.
- W1847804829 cites W1992485430 @default.
- W1847804829 cites W1994269934 @default.
- W1847804829 cites W1998879888 @default.
- W1847804829 cites W2003500892 @default.
- W1847804829 cites W2015939473 @default.
- W1847804829 cites W2016090961 @default.
- W1847804829 cites W2016859011 @default.
- W1847804829 cites W2022494256 @default.
- W1847804829 cites W2035523654 @default.
- W1847804829 cites W2038102843 @default.
- W1847804829 cites W2042365508 @default.
- W1847804829 cites W2042738968 @default.
- W1847804829 cites W2043275895 @default.
- W1847804829 cites W2053432537 @default.
- W1847804829 cites W2053495452 @default.
- W1847804829 cites W2058797249 @default.
- W1847804829 cites W2060542207 @default.
- W1847804829 cites W2061829402 @default.
- W1847804829 cites W2063622539 @default.
- W1847804829 cites W2067144363 @default.
- W1847804829 cites W2070274336 @default.
- W1847804829 cites W2073274892 @default.
- W1847804829 cites W2073597876 @default.
- W1847804829 cites W2074198216 @default.
- W1847804829 cites W2087347915 @default.
- W1847804829 cites W2091729375 @default.
- W1847804829 cites W2103611039 @default.
- W1847804829 cites W2111773119 @default.
- W1847804829 cites W2125300645 @default.
- W1847804829 cites W2127745150 @default.
- W1847804829 cites W2132577566 @default.
- W1847804829 cites W2136810701 @default.
- W1847804829 cites W2140114244 @default.
- W1847804829 cites W2142746235 @default.
- W1847804829 cites W2145894855 @default.
- W1847804829 cites W2146149549 @default.
- W1847804829 cites W2157976581 @default.
- W1847804829 cites W2184361051 @default.
- W1847804829 cites W4256236482 @default.
- W1847804829 cites W2025112195 @default.
- W1847804829 doi "https://doi.org/10.18632/oncotarget.3861" @default.
- W1847804829 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4653033" @default.
- W1847804829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25970782" @default.
- W1847804829 hasPublicationYear "2015" @default.
- W1847804829 type Work @default.
- W1847804829 sameAs 1847804829 @default.
- W1847804829 citedByCount "30" @default.
- W1847804829 countsByYear W18478048292017 @default.
- W1847804829 countsByYear W18478048292018 @default.
- W1847804829 countsByYear W18478048292019 @default.
- W1847804829 countsByYear W18478048292020 @default.
- W1847804829 countsByYear W18478048292021 @default.
- W1847804829 countsByYear W18478048292022 @default.
- W1847804829 countsByYear W18478048292023 @default.
- W1847804829 crossrefType "journal-article" @default.
- W1847804829 hasAuthorship W1847804829A5029695887 @default.
- W1847804829 hasAuthorship W1847804829A5029932798 @default.
- W1847804829 hasAuthorship W1847804829A5032561728 @default.
- W1847804829 hasAuthorship W1847804829A5046676712 @default.
- W1847804829 hasAuthorship W1847804829A5051764626 @default.
- W1847804829 hasAuthorship W1847804829A5069522797 @default.
- W1847804829 hasAuthorship W1847804829A5078264996 @default.
- W1847804829 hasAuthorship W1847804829A5082255460 @default.
- W1847804829 hasBestOaLocation W18478048291 @default.
- W1847804829 hasConcept C104317684 @default.
- W1847804829 hasConcept C10515644 @default.
- W1847804829 hasConcept C121608353 @default.
- W1847804829 hasConcept C126322002 @default.
- W1847804829 hasConcept C127561419 @default.
- W1847804829 hasConcept C143998085 @default.
- W1847804829 hasConcept C146357865 @default.
- W1847804829 hasConcept C150194340 @default.
- W1847804829 hasConcept C151730666 @default.
- W1847804829 hasConcept C2775997469 @default.
- W1847804829 hasConcept C2776534502 @default.
- W1847804829 hasConcept C2777546739 @default.
- W1847804829 hasConcept C502942594 @default.
- W1847804829 hasConcept C54355233 @default.
- W1847804829 hasConcept C71924100 @default.