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• W1848041239 endingPage "150" @default.
• W1848041239 startingPage "142" @default.
• W1848041239 abstract "Aflatoxin B1 (AFB1) is primarily biotransformed in the liver by cytochrome P450 (CYP) enzymes, which can yield either the genotoxic metabolite AFB1-8,9 epoxide that causes liver carcinogenicity or less toxic compounds. The biotransformation of AFB1 is better understood in humans, including gene expression of CYPs involved in the detoxification process. Studies on farm animals have demonstrated genes homologous to human CYPs that play similar roles in AFB1 biotransformation. This review compares the activities of the most important CYPs related to the biotransformation of AFB1 in humans, swine and domestic fowls (chickens, quail, turkeys and ducks), as well the main detoxification mechanisms in these species." @default.
• W1848041239 created "2016-06-24" @default.
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• W1848041239 date "2015-07-03" @default.
• W1848041239 modified "2023-09-25" @default.
• W1848041239 title "Comparative biotransformation of aflatoxin B₁in swine, domestic fowls, and humans" @default.
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• W1848041239 doi "https://doi.org/10.3109/15569543.2015.1091979" @default.
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