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- W1848328006 abstract "This chapter discusses the mechanisms of eukaryotic ribosomal transcription and its regulation. Ribosomal transcription has been studied in an exceptionally wide range of organisms. In eukaryotes, ribosomal gene transcription uses a dedicated set of transcription factors and a specialized ribonucleic acid (RNA) polymerase, the deoxyribonucleic acid (DNA)-dependent RNA polymerase I (RPOI). The resultant precursor-rRNA (pre-rRNA) is neither capped nor polyadenylated and is produced in the nucleolus; a large nuclear structure visible in the light microscope. Moreover, the promotion of ribosomal transcription is generally directed, by a 100- to 150-bp DNA sequence that lies across and, predominantly, upstream of the transcription-initiation site. Promotion requires an activated form of RPOI, the DNA-binding factor upstream transcription factor (UBF), and the TATA binding protein (TBP)I-complex, containing three TATA-box binding protein associated protein (TAF)Is. Upstream binding factor (UBF) binds to both an upstream and an initiation-site promoter element, probably coiling the promoter into a 180-bp loop. This allows the interaction of the TBP,-complex, and subsequent polymerase recruitment. The activity of the promoter is enhanced by a promoter-proximal terminator, by enhancer repeats in the proximal IGS, and by the presence in the IGS of duplicate spacer promoters. Further upstream, other sequences may also modulate transcription." @default.
- W1848328006 created "2016-06-24" @default.
- W1848328006 creator A5055158232 @default.
- W1848328006 creator A5089829367 @default.
- W1848328006 date "1995-01-01" @default.
- W1848328006 modified "2023-10-12" @default.
- W1848328006 title "Promotion and Regulation of Ribosomal Transcription in Eukaryotes by RNA Polymerase" @default.
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