FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1848483485> ?p ?o ?g. }

• W1848483485 abstract "The steady increase in the incidence of obesity among adults has been paralleled with higher levels of obesity-associated breast cancer. While recent studies have suggested that adipose stromal/stem cells (ASCs) isolated from obese women enhance tumorigenicity, the mechanism(s) by which this occurs remains undefined. Evidence suggests that increased adiposity results in increased leptin secretion from adipose tissue, which has been shown to increased cancer cell proliferation. Previously, our group demonstrated that ASCs isolated from obese women (obASCs) also express higher levels of leptin relative to ASCs isolated from lean women (lnASCs) and that this obASC-derived leptin may account for enhanced breast cancer cell growth. The current study investigates the impact of inhibiting leptin expression in lnASCs and obASCs on breast cancer cell (BCC) growth and progression. Estrogen receptor positive (ER+) BCCs were co-cultured with leptin shRNA lnASCs or leptin shRNA obASCs and changes in the proliferation, migration, invasion, and gene expression of BCCs were investigated. To assess the direct impact of leptin inhibition in obASCs on BCC proliferation, MCF7 cells were injected alone or mixed with control shRNA obASCs or leptin shRNA obASCs into SCID/beige mice. ER+ BCCs were responsive to obASCs during direct co-culture, whereas lnASCs were unable to increase ER+ BCC growth. shRNA silencing of leptin in obASCs negated the enhanced proliferative effects of obASC on BCCs following direct co-culture. BCCs co-cultured with obASCs demonstrated enhanced expression of epithelial-to-mesenchymal transition (EMT) and metastasis genes (SERPINE1, MMP-2, and IL-6), while BCCs co-cultured with leptin shRNA obASCs did not display similar levels of gene induction. Knockdown of leptin significantly reduced tumor volume and decreased the number of metastatic lesions to the lung and liver. These results correlated with reduced expression of both SERPINE1 and MMP-2 in tumors formed with MCF7 cells mixed with leptin shRNA obASCs, when compared to tumors formed with MCF7 cells mixed with control shRNA obASCs. This study provides mechanistic insight as to how obesity enhances the proliferation and metastasis of breast cancer cells; specifically, obASC-derived leptin contributes to the aggressiveness of breast cancer in obese women." @default.
• W1848483485 created "2016-06-24" @default.
• W1848483485 creator A5001867555 @default.
• W1848483485 creator A5008755236 @default.
• W1848483485 creator A5019178132 @default.
• W1848483485 creator A5019475620 @default.
• W1848483485 creator A5026038537 @default.
• W1848483485 creator A5032342203 @default.
• W1848483485 creator A5036869902 @default.
• W1848483485 creator A5045202889 @default.
• W1848483485 creator A5048983251 @default.
• W1848483485 creator A5058795691 @default.
• W1848483485 creator A5061333335 @default.
• W1848483485 creator A5081200479 @default.
• W1848483485 creator A5081860821 @default.
• W1848483485 date "2015-08-19" @default.
• W1848483485 modified "2023-10-15" @default.
• W1848483485 title "Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers" @default.
• W1848483485 cites W1564770936 @default.
• W1848483485 cites W16253337 @default.
• W1848483485 cites W1966659619 @default.
• W1848483485 cites W1968851824 @default.
• W1848483485 cites W1974875705 @default.
• W1848483485 cites W1988806762 @default.
• W1848483485 cites W1994059078 @default.
• W1848483485 cites W1994525965 @default.
• W1848483485 cites W1996451338 @default.
• W1848483485 cites W2002019450 @default.
• W1848483485 cites W2002308570 @default.
• W1848483485 cites W2011540227 @default.
• W1848483485 cites W2012587702 @default.
• W1848483485 cites W2013336992 @default.
• W1848483485 cites W2014174049 @default.
• W1848483485 cites W2025193872 @default.
• W1848483485 cites W2025663730 @default.
• W1848483485 cites W2028819093 @default.
• W1848483485 cites W2034855235 @default.
• W1848483485 cites W2035811939 @default.
• W1848483485 cites W2038183997 @default.
• W1848483485 cites W2040712355 @default.
• W1848483485 cites W2050752490 @default.
• W1848483485 cites W2052593722 @default.
• W1848483485 cites W2057010510 @default.
• W1848483485 cites W2062809449 @default.
• W1848483485 cites W2068176536 @default.
• W1848483485 cites W2072914828 @default.
• W1848483485 cites W2080602006 @default.
• W1848483485 cites W2081549959 @default.
• W1848483485 cites W2083156208 @default.
• W1848483485 cites W2083281068 @default.
• W1848483485 cites W2107832644 @default.
• W1848483485 cites W2108882629 @default.
• W1848483485 cites W2111923039 @default.
• W1848483485 cites W2117692326 @default.
• W1848483485 cites W2118977196 @default.
• W1848483485 cites W2120408896 @default.
• W1848483485 cites W2129204158 @default.
• W1848483485 cites W2140457971 @default.
• W1848483485 cites W2141662760 @default.
• W1848483485 cites W2151172917 @default.
• W1848483485 cites W2151320729 @default.
• W1848483485 cites W2152913697 @default.
• W1848483485 cites W2153383900 @default.
• W1848483485 cites W2157795870 @default.
• W1848483485 cites W2160590419 @default.
• W1848483485 cites W2160852563 @default.
• W1848483485 cites W2163135881 @default.
• W1848483485 cites W2167543957 @default.
• W1848483485 cites W2171063222 @default.
• W1848483485 cites W2613056846 @default.
• W1848483485 cites W3148261934 @default.
• W1848483485 cites W4205370185 @default.
• W1848483485 doi "https://doi.org/10.1186/s13058-015-0622-z" @default.
• W1848483485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4541745" @default.
• W1848483485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26286584" @default.
• W1848483485 hasPublicationYear "2015" @default.
• W1848483485 type Work @default.
• W1848483485 sameAs 1848483485 @default.
• W1848483485 citedByCount "152" @default.
• W1848483485 countsByYear W18484834852015 @default.
• W1848483485 countsByYear W18484834852016 @default.
• W1848483485 countsByYear W18484834852017 @default.
• W1848483485 countsByYear W18484834852018 @default.
• W1848483485 countsByYear W18484834852019 @default.
• W1848483485 countsByYear W18484834852020 @default.
• W1848483485 countsByYear W18484834852021 @default.
• W1848483485 countsByYear W18484834852022 @default.
• W1848483485 countsByYear W18484834852023 @default.
• W1848483485 crossrefType "journal-article" @default.
• W1848483485 hasAuthorship W1848483485A5001867555 @default.
• W1848483485 hasAuthorship W1848483485A5008755236 @default.
• W1848483485 hasAuthorship W1848483485A5019178132 @default.
• W1848483485 hasAuthorship W1848483485A5019475620 @default.
• W1848483485 hasAuthorship W1848483485A5026038537 @default.
• W1848483485 hasAuthorship W1848483485A5032342203 @default.
• W1848483485 hasAuthorship W1848483485A5036869902 @default.
• W1848483485 hasAuthorship W1848483485A5045202889 @default.
• W1848483485 hasAuthorship W1848483485A5048983251 @default.
• W1848483485 hasAuthorship W1848483485A5058795691 @default.
• W1848483485 hasAuthorship W1848483485A5061333335 @default.

• next