Matches in SemOpenAlex for { <https://semopenalex.org/work/W1848504704> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1848504704 abstract "Several important effects of nitric oxide (NO) and natriuretic peptides (ANP, BNP, & CNP) are mediated by cyclic guanosine monophosphate (cGMP) and cGMP-dependent protein kinase type I (cGKI). Recent studies indicated that the cGMP pathway might also play a role in tumorigenesis. However, the cellular and molecular mechanisms of cGMP's effects on tumor growth are not well understood. In the present study, the expression and function of components of the cGMP pathway in melanoma cell lines of murine and human origin were investigated. We found that murine B16 melanoma cells express cGKI and treatment of the cells with the cell-permeable cGMP analog 8-bromo-cGMP induced the phosphorylation of cGKI substrate proteins VASP and PDE5. CNP, a ligand of the particulate guanylyl cyclase GC-B, but not NO or ANP, induced robust cGMP signals in melanoma cells. Interestingly, activation of the CNP-cGMP-cGKI pathway increased the growth and migration of B16 cells through a crosstalk with p44/42 MAPK signaling. The PDE5 inhibitor sildenafil enhanced CNP-mediated cGMP signaling and the growth of murine melanoma cells. Similar results were obtained with human melanoma cell lines. In line with the in vitro data, we found that cGKI overexpression in melanoma cells or administration of sildenafil promoted melanoma growth in vivo in mice. Finally, expression of cGKI was also detected in cancer cells of human melanoma patients. Taken together, we have identified a CNP-cGMP-cGKI-MAPK pathway in melanoma cells, which stimulates melanoma cell growth in vitro and in vivo and might be novel therapeutic target for treatment of melanoma." @default.
- W1848504704 created "2016-06-24" @default.
- W1848504704 creator A5004823373 @default.
- W1848504704 creator A5013089574 @default.
- W1848504704 creator A5013523952 @default.
- W1848504704 creator A5064901405 @default.
- W1848504704 creator A5078265837 @default.
- W1848504704 creator A5079350808 @default.
- W1848504704 creator A5079582665 @default.
- W1848504704 creator A5080628640 @default.
- W1848504704 creator A5082866371 @default.
- W1848504704 creator A5085166008 @default.
- W1848504704 date "2015-09-02" @default.
- W1848504704 modified "2023-10-08" @default.
- W1848504704 title "A CNP-cGMP-cGKI-MAPK pathway promotes melanoma growth in vitro and in vivo in mice" @default.
- W1848504704 doi "https://doi.org/10.1186/2050-6511-16-s1-a49" @default.
- W1848504704 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4565535" @default.
- W1848504704 hasPublicationYear "2015" @default.
- W1848504704 type Work @default.
- W1848504704 sameAs 1848504704 @default.
- W1848504704 citedByCount "0" @default.
- W1848504704 crossrefType "journal-article" @default.
- W1848504704 hasAuthorship W1848504704A5004823373 @default.
- W1848504704 hasAuthorship W1848504704A5013089574 @default.
- W1848504704 hasAuthorship W1848504704A5013523952 @default.
- W1848504704 hasAuthorship W1848504704A5064901405 @default.
- W1848504704 hasAuthorship W1848504704A5078265837 @default.
- W1848504704 hasAuthorship W1848504704A5079350808 @default.
- W1848504704 hasAuthorship W1848504704A5079582665 @default.
- W1848504704 hasAuthorship W1848504704A5080628640 @default.
- W1848504704 hasAuthorship W1848504704A5082866371 @default.
- W1848504704 hasAuthorship W1848504704A5085166008 @default.
- W1848504704 hasBestOaLocation W18485047041 @default.
- W1848504704 hasConcept C134018914 @default.
- W1848504704 hasConcept C150903083 @default.
- W1848504704 hasConcept C184235292 @default.
- W1848504704 hasConcept C185592680 @default.
- W1848504704 hasConcept C207001950 @default.
- W1848504704 hasConcept C2777658100 @default.
- W1848504704 hasConcept C2780994212 @default.
- W1848504704 hasConcept C502942594 @default.
- W1848504704 hasConcept C519581460 @default.
- W1848504704 hasConcept C55493867 @default.
- W1848504704 hasConcept C57074206 @default.
- W1848504704 hasConcept C62112901 @default.
- W1848504704 hasConcept C62478195 @default.
- W1848504704 hasConcept C86803240 @default.
- W1848504704 hasConcept C95444343 @default.
- W1848504704 hasConcept C97029542 @default.
- W1848504704 hasConceptScore W1848504704C134018914 @default.
- W1848504704 hasConceptScore W1848504704C150903083 @default.
- W1848504704 hasConceptScore W1848504704C184235292 @default.
- W1848504704 hasConceptScore W1848504704C185592680 @default.
- W1848504704 hasConceptScore W1848504704C207001950 @default.
- W1848504704 hasConceptScore W1848504704C2777658100 @default.
- W1848504704 hasConceptScore W1848504704C2780994212 @default.
- W1848504704 hasConceptScore W1848504704C502942594 @default.
- W1848504704 hasConceptScore W1848504704C519581460 @default.
- W1848504704 hasConceptScore W1848504704C55493867 @default.
- W1848504704 hasConceptScore W1848504704C57074206 @default.
- W1848504704 hasConceptScore W1848504704C62112901 @default.
- W1848504704 hasConceptScore W1848504704C62478195 @default.
- W1848504704 hasConceptScore W1848504704C86803240 @default.
- W1848504704 hasConceptScore W1848504704C95444343 @default.
- W1848504704 hasConceptScore W1848504704C97029542 @default.
- W1848504704 hasLocation W18485047041 @default.
- W1848504704 hasLocation W18485047042 @default.
- W1848504704 hasLocation W18485047043 @default.
- W1848504704 hasOpenAccess W1848504704 @default.
- W1848504704 hasPrimaryLocation W18485047041 @default.
- W1848504704 hasRelatedWork W1973417966 @default.
- W1848504704 hasRelatedWork W1975585680 @default.
- W1848504704 hasRelatedWork W1978312362 @default.
- W1848504704 hasRelatedWork W1990424719 @default.
- W1848504704 hasRelatedWork W1992439664 @default.
- W1848504704 hasRelatedWork W2003085149 @default.
- W1848504704 hasRelatedWork W2041453811 @default.
- W1848504704 hasRelatedWork W2042552059 @default.
- W1848504704 hasRelatedWork W2044697354 @default.
- W1848504704 hasRelatedWork W2049943742 @default.
- W1848504704 hasRelatedWork W2063039639 @default.
- W1848504704 hasRelatedWork W2067800556 @default.
- W1848504704 hasRelatedWork W2079369070 @default.
- W1848504704 hasRelatedWork W2102344039 @default.
- W1848504704 hasRelatedWork W2131466790 @default.
- W1848504704 hasRelatedWork W2137945618 @default.
- W1848504704 hasRelatedWork W2145125577 @default.
- W1848504704 hasRelatedWork W2156786194 @default.
- W1848504704 hasRelatedWork W3004975898 @default.
- W1848504704 hasRelatedWork W33423123 @default.
- W1848504704 isParatext "false" @default.
- W1848504704 isRetracted "false" @default.
- W1848504704 magId "1848504704" @default.
- W1848504704 workType "article" @default.