FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1848613573> ?p ?o ?g. }

• W1848613573 endingPage "3048" @default.
• W1848613573 startingPage "3039" @default.
• W1848613573 abstract "Immunodominance refers to the restricted peptide specificity of T cells that are detectable after an adaptive immune response. For CD4 T cells, many of the mechanisms used to explain this selectivity suggest that events related to Ag processing play a major role in determining a peptide's ability to recruit CD4 T cells. Implicit in these models is the prediction that the molecular context in which an antigenic peptide is contained will impact significantly on its immunodominance. In this study, we present evidence that the selectivity of CD4 T cell responses to peptides contained within protein Ags is not detectably influenced by the location of the peptide in a given protein or the primary sequence of the protein that bears the test peptide. We have used molecular approaches to change the location of peptides within complex protein Ags and to change the flanking sequences that border the peptide epitope to now include a protease site, and find that immunodominance or crypticity of a peptide observed in its native protein context is preserved. Collectively, these results suggest immunodominance of peptides contained in complex Ags is due to an intrinsic factor of the peptide, based upon the affinity of that peptide for MHC class II molecules. These findings are discussed with regard to implications for vaccine design." @default.
• W1848613573 created "2016-06-24" @default.
• W1848613573 creator A5028896091 @default.
• W1848613573 creator A5042269057 @default.
• W1848613573 creator A5048259074 @default.
• W1848613573 creator A5053826971 @default.
• W1848613573 creator A5074802230 @default.
• W1848613573 creator A5077767047 @default.
• W1848613573 creator A5082455986 @default.
• W1848613573 date "2008-09-01" @default.
• W1848613573 modified "2023-10-10" @default.
• W1848613573 title "Immunodominance of CD4 T Cells to Foreign Antigens Is Peptide Intrinsic and Independent of Molecular Context: Implications for Vaccine Design" @default.
• W1848613573 cites W1492436048 @default.
• W1848613573 cites W1518475556 @default.
• W1848613573 cites W1521958691 @default.
• W1848613573 cites W1533530009 @default.
• W1848613573 cites W1541850700 @default.
• W1848613573 cites W1586085788 @default.
• W1848613573 cites W1591105009 @default.
• W1848613573 cites W1594237361 @default.
• W1848613573 cites W1605787182 @default.
• W1848613573 cites W1612135387 @default.
• W1848613573 cites W1650026319 @default.
• W1848613573 cites W1655254278 @default.
• W1848613573 cites W1680217275 @default.
• W1848613573 cites W1873705845 @default.
• W1848613573 cites W1937758884 @default.
• W1848613573 cites W1961534104 @default.
• W1848613573 cites W1964335421 @default.
• W1848613573 cites W1966667477 @default.
• W1848613573 cites W1971140238 @default.
• W1848613573 cites W1973816981 @default.
• W1848613573 cites W1974603911 @default.
• W1848613573 cites W1978790143 @default.
• W1848613573 cites W1982034991 @default.
• W1848613573 cites W1983355123 @default.
• W1848613573 cites W1985859196 @default.
• W1848613573 cites W1990170496 @default.
• W1848613573 cites W1991790007 @default.
• W1848613573 cites W1992196706 @default.
• W1848613573 cites W1993219476 @default.
• W1848613573 cites W2003042213 @default.
• W1848613573 cites W2006010160 @default.
• W1848613573 cites W2008072330 @default.
• W1848613573 cites W2012549218 @default.
• W1848613573 cites W2013857975 @default.
• W1848613573 cites W2020403061 @default.
• W1848613573 cites W2020690016 @default.
• W1848613573 cites W2022527113 @default.
• W1848613573 cites W2024750905 @default.
• W1848613573 cites W2025956257 @default.
• W1848613573 cites W2026308440 @default.
• W1848613573 cites W2028663182 @default.
• W1848613573 cites W2032395021 @default.
• W1848613573 cites W2034570325 @default.
• W1848613573 cites W2035470798 @default.
• W1848613573 cites W2040993569 @default.
• W1848613573 cites W2044089689 @default.
• W1848613573 cites W2045209342 @default.
• W1848613573 cites W2046060933 @default.
• W1848613573 cites W2050947321 @default.
• W1848613573 cites W2055129186 @default.
• W1848613573 cites W2056651081 @default.
• W1848613573 cites W2058641297 @default.
• W1848613573 cites W2061559491 @default.
• W1848613573 cites W2062254683 @default.
• W1848613573 cites W2063799316 @default.
• W1848613573 cites W2068441119 @default.
• W1848613573 cites W2069102668 @default.
• W1848613573 cites W2070965027 @default.
• W1848613573 cites W2072034032 @default.
• W1848613573 cites W2072133358 @default.
• W1848613573 cites W2072925709 @default.
• W1848613573 cites W2075492673 @default.
• W1848613573 cites W2075514508 @default.
• W1848613573 cites W2078002995 @default.
• W1848613573 cites W2082446741 @default.
• W1848613573 cites W2082528610 @default.
• W1848613573 cites W2086274485 @default.
• W1848613573 cites W2086566503 @default.
• W1848613573 cites W2087106927 @default.
• W1848613573 cites W2093378622 @default.
• W1848613573 cites W2097398162 @default.
• W1848613573 cites W2101340968 @default.
• W1848613573 cites W2102860956 @default.
• W1848613573 cites W2103647145 @default.
• W1848613573 cites W2103963042 @default.
• W1848613573 cites W2109339076 @default.
• W1848613573 cites W2110379511 @default.
• W1848613573 cites W2111246573 @default.
• W1848613573 cites W2115873946 @default.
• W1848613573 cites W2118358914 @default.
• W1848613573 cites W2126142960 @default.
• W1848613573 cites W2128194054 @default.
• W1848613573 cites W2129304079 @default.
• W1848613573 cites W2129609598 @default.
• W1848613573 cites W2131148779 @default.
• W1848613573 cites W2132846984 @default.

• next