FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1848935986> ?p ?o ?g. }

• W1848935986 endingPage "mvw091" @default.
• W1848935986 startingPage "mvw091" @default.
• W1848935986 abstract "The 26S proteasome is a 2.5-MDa complex responsible for the selective, ATP-dependent degradation of ubiquitylated proteins in eukaryotic cells. Substrates in hundreds cellular pathways are timely ubiquitylated and converged to the proteasome by direct recognition or by multiple shuttle factors. Engagement of substrate protein triggers conformational changes of the proteasome, which drive substrate unfolding, deubiquitylation and translocation of substrates to proteolytic sites. Recent studies have challenged the previous paradigm that Lys48-linked tetraubiquitin is a minimal degradation signal: in addition, monoubiquitylation or multiple short ubiquitylations can serve as the targeting signal for proteasomal degradation. In this review, I highlight recent advances in our understanding of the proteasome structure, the ubiquitin topology in proteasome targeting, and the cellular factors that regulate proteasomal degradation." @default.
• W1848935986 created "2016-06-24" @default.
• W1848935986 creator A5018866207 @default.
• W1848935986 date "2017-01-08" @default.
• W1848935986 modified "2023-10-03" @default.
• W1848935986 title "Ubiquitin recognition by the proteasome" @default.
• W1848935986 cites W136634311 @default.
• W1848935986 cites W1482509014 @default.
• W1848935986 cites W1496897161 @default.
• W1848935986 cites W1516878062 @default.
• W1848935986 cites W1800844013 @default.
• W1848935986 cites W1918329266 @default.
• W1848935986 cites W1941369368 @default.
• W1848935986 cites W1960421135 @default.
• W1848935986 cites W1966993307 @default.
• W1848935986 cites W1976169230 @default.
• W1848935986 cites W1977502249 @default.
• W1848935986 cites W1977733856 @default.
• W1848935986 cites W1979674511 @default.
• W1848935986 cites W1980876888 @default.
• W1848935986 cites W1983633543 @default.
• W1848935986 cites W1986429623 @default.
• W1848935986 cites W1987467454 @default.
• W1848935986 cites W1990283498 @default.
• W1848935986 cites W1991930087 @default.
• W1848935986 cites W1992798036 @default.
• W1848935986 cites W1997827461 @default.
• W1848935986 cites W2000409052 @default.
• W1848935986 cites W2006892470 @default.
• W1848935986 cites W2006975754 @default.
• W1848935986 cites W2007003700 @default.
• W1848935986 cites W2007185935 @default.
• W1848935986 cites W2008775082 @default.
• W1848935986 cites W2013339424 @default.
• W1848935986 cites W2014593228 @default.
• W1848935986 cites W2017033636 @default.
• W1848935986 cites W2019929587 @default.
• W1848935986 cites W2024324790 @default.
• W1848935986 cites W2028038380 @default.
• W1848935986 cites W2029888437 @default.
• W1848935986 cites W2035094622 @default.
• W1848935986 cites W2036380827 @default.
• W1848935986 cites W2040914206 @default.
• W1848935986 cites W2041136562 @default.
• W1848935986 cites W2041417196 @default.
• W1848935986 cites W2044086279 @default.
• W1848935986 cites W2044843127 @default.
• W1848935986 cites W2047455709 @default.
• W1848935986 cites W2050586659 @default.
• W1848935986 cites W2051641469 @default.
• W1848935986 cites W2052302154 @default.
• W1848935986 cites W2056020080 @default.
• W1848935986 cites W2056373544 @default.
• W1848935986 cites W2056607803 @default.
• W1848935986 cites W2057152378 @default.
• W1848935986 cites W2058496850 @default.
• W1848935986 cites W2058532554 @default.
• W1848935986 cites W2058775823 @default.
• W1848935986 cites W2061050157 @default.
• W1848935986 cites W2063264874 @default.
• W1848935986 cites W2066107334 @default.
• W1848935986 cites W2068408381 @default.
• W1848935986 cites W2069494008 @default.
• W1848935986 cites W2072981065 @default.
• W1848935986 cites W2077292361 @default.
• W1848935986 cites W2080182587 @default.
• W1848935986 cites W2080378383 @default.
• W1848935986 cites W2080416353 @default.
• W1848935986 cites W2080625914 @default.
• W1848935986 cites W2085175631 @default.
• W1848935986 cites W2096646435 @default.
• W1848935986 cites W2097062199 @default.
• W1848935986 cites W2097164847 @default.
• W1848935986 cites W2099095224 @default.
• W1848935986 cites W2099161824 @default.
• W1848935986 cites W2101066284 @default.
• W1848935986 cites W2103552916 @default.
• W1848935986 cites W2105469941 @default.
• W1848935986 cites W2106667875 @default.
• W1848935986 cites W2108279225 @default.
• W1848935986 cites W2112064435 @default.
• W1848935986 cites W2128296472 @default.
• W1848935986 cites W2132535068 @default.
• W1848935986 cites W2139837621 @default.
• W1848935986 cites W2140533536 @default.
• W1848935986 cites W2143538182 @default.
• W1848935986 cites W2144112169 @default.
• W1848935986 cites W2144593863 @default.
• W1848935986 cites W2145281326 @default.
• W1848935986 cites W2147917253 @default.
• W1848935986 cites W2150379282 @default.
• W1848935986 cites W2156739666 @default.
• W1848935986 cites W2160087776 @default.
• W1848935986 cites W2166475702 @default.
• W1848935986 cites W2166987747 @default.
• W1848935986 cites W2167265589 @default.
• W1848935986 cites W2170568632 @default.
• W1848935986 cites W2171862076 @default.

• next