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- W1849106730 abstract "Aim: We performed a systematic review and meta-analysis of the correlation beween cetuximab-induced skin rash and outcomes of solid tumor patients treated with cetuximab. Methods: Eligible studies included phase I, II and III trials of patients with solid tumors on cetuximab; describing events of skin rash and correlating skin rash with overall survival (OS), progression free survival (PFS) and/or overall response rate (ORR). Results: Our search strategy yielded 409 potentially relevant citations on CETUXIMAB from Pubmed/Medline, CENTRAL Cochrane registry and ASCO meeting library. After exclusion of ineligible studies, a total of 13 clinical trials were considered eligible for the meta-analysis, including 4 phase III trials, 8 phase II trials and one phase I trial. The occurrence of cetuximab-induced rash in patients was highly associated with improvements in PFS (HR = 0.74; 95% CI: 0.63–0.86, P <0.0002), OS (HR = 0.60; 95% CI: 0.47–0.76, P <0.0001), and ORR (RR = 1.51, 95% CI: 1.26–1.81, P <0.00001), as compared to patients without rash. Exploratory subgroup analysis showed no effect of tumor types on the RR of ORR. Conclusions: Our meta-analysis has demonstrated that CETUXIMAB-induced rash is associated with a significantly increased improved OS, PFS and ORR. cetuximab-induced skin rash may represent a prognostic factor in patients with advanced solid tumors. Disclosure: All authors have declared no conflicts of interest." @default.
- W1849106730 created "2016-06-24" @default.
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- W1849106730 date "2014-09-01" @default.
- W1849106730 modified "2023-09-29" @default.
- W1849106730 title "Correlation of Cetuximab-Induced Skin Rash and Outcomes of Solid Tumor Patients Treated with Cetuximab: a Meta-Analysis" @default.
- W1849106730 doi "https://doi.org/10.1093/annonc/mdu326.78" @default.
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