FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1849270082> ?p ?o ?g. }

• W1849270082 endingPage "1709" @default.
• W1849270082 startingPage "1697" @default.
• W1849270082 abstract "Current-clamp recordings were made from the deep cerebellar nuclei (DCN) of 12- to 15-day-old rats to understand the factors that mediate intrinsic spontaneous firing patterns. All of the cells recorded were spontaneously active with spiking patterns ranging continuously from regular spiking to spontaneous bursting with the former predominating. A robust rebound depolarization (RD) leading to a Na(+) spike burst was elicited after the offset of hyperpolarizing current injection. The voltage and time dependence of the RD was consistent with mediation by low-threshold voltage-gated Ca(2+) channels. In addition, induction of a RD also may be affected by activation of a hyperpolarization-activated cation current, I(h). A RD could be evoked efficiently after brief high-frequency bursts of inhibitory postsynaptic potentials (IPSPs) induced by stimulation of Purkinje cell axons. IPSP-driven RDs were typically much larger and longer than those elicited by direct hyperpolarizing pulses of approximately matched amplitude and duration. Intracellular perfusion of the Ca(2+) buffer bis-(o-aminophenoxy)-N,N,N',N'-tetraacetic acid (BAPTA) dramatically enhanced the RD and its associated spiking, sometimes leading to a plateau potential that lasted several hundred milliseconds. The effects of BAPTA could be mimicked partly by application of apamin, a blocker of small conductance Ca(2+)-gated K(+) channels, but not by paxilline, which blocks large conductance Ca(2+)-gated K(+) channels. Application of both BAPTA and apamin, but not paxilline, caused cells that were regularly spiking to burst spontaneously. Taken together, our data suggest that there is a strong relationship between the ability of DCN cells to elicit a RD and their tendency burst spontaneously. The RD can be triggered by the opening of T-type Ca(2+) channels with an additional contribution of hyperpolarization-activated current I(h). RD duration is regulated by small-conductance Ca(2+)-gated K(+) channels. The RD also is modulated tonically by inhibitory inputs. All of these factors are in turn subject to alteration by extrinsic modulatory neurotransmitters and are, at least in part, responsible for determining the firing modes of DCN neurons." @default.
• W1849270082 created "2016-06-24" @default.
• W1849270082 creator A5002661645 @default.
• W1849270082 creator A5025508358 @default.
• W1849270082 date "1999-10-01" @default.
• W1849270082 modified "2023-10-16" @default.
• W1849270082 title "Regulation of the Rebound Depolarization and Spontaneous Firing Patterns of Deep Nuclear Neurons in Slices of Rat Cerebellum" @default.
• W1849270082 cites W1490915066 @default.
• W1849270082 cites W1858330232 @default.
• W1849270082 cites W1966472585 @default.
• W1849270082 cites W1971356217 @default.
• W1849270082 cites W1978004285 @default.
• W1849270082 cites W1978734924 @default.
• W1849270082 cites W1981835900 @default.
• W1849270082 cites W1985249648 @default.
• W1849270082 cites W1986887981 @default.
• W1849270082 cites W1990798621 @default.
• W1849270082 cites W1991186988 @default.
• W1849270082 cites W1991424097 @default.
• W1849270082 cites W1998944286 @default.
• W1849270082 cites W1999921358 @default.
• W1849270082 cites W2003961668 @default.
• W1849270082 cites W2014170268 @default.
• W1849270082 cites W2014725799 @default.
• W1849270082 cites W2017656839 @default.
• W1849270082 cites W2026823182 @default.
• W1849270082 cites W2035127927 @default.
• W1849270082 cites W2035845442 @default.
• W1849270082 cites W2037734362 @default.
• W1849270082 cites W2043362947 @default.
• W1849270082 cites W2060617371 @default.
• W1849270082 cites W2066922852 @default.
• W1849270082 cites W2068491414 @default.
• W1849270082 cites W2071052205 @default.
• W1849270082 cites W2072802414 @default.
• W1849270082 cites W2074797643 @default.
• W1849270082 cites W2083658132 @default.
• W1849270082 cites W2112196515 @default.
• W1849270082 cites W2118212641 @default.
• W1849270082 cites W2125378452 @default.
• W1849270082 cites W2131921751 @default.
• W1849270082 cites W2132338462 @default.
• W1849270082 cites W2138351132 @default.
• W1849270082 cites W2142315029 @default.
• W1849270082 cites W2148901385 @default.
• W1849270082 cites W2150666125 @default.
• W1849270082 cites W2160634623 @default.
• W1849270082 cites W2171390108 @default.
• W1849270082 cites W2178459653 @default.
• W1849270082 cites W2245561430 @default.
• W1849270082 cites W2259746891 @default.
• W1849270082 cites W2336012460 @default.
• W1849270082 cites W4214868137 @default.
• W1849270082 cites W9541871 @default.
• W1849270082 doi "https://doi.org/10.1152/jn.1999.82.4.1697" @default.
• W1849270082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10515960" @default.
• W1849270082 hasPublicationYear "1999" @default.
• W1849270082 type Work @default.
• W1849270082 sameAs 1849270082 @default.
• W1849270082 citedByCount "305" @default.
• W1849270082 countsByYear W18492700822012 @default.
• W1849270082 countsByYear W18492700822013 @default.
• W1849270082 countsByYear W18492700822014 @default.
• W1849270082 countsByYear W18492700822015 @default.
• W1849270082 countsByYear W18492700822016 @default.
• W1849270082 countsByYear W18492700822017 @default.
• W1849270082 countsByYear W18492700822018 @default.
• W1849270082 countsByYear W18492700822019 @default.
• W1849270082 countsByYear W18492700822020 @default.
• W1849270082 countsByYear W18492700822021 @default.
• W1849270082 countsByYear W18492700822022 @default.
• W1849270082 countsByYear W18492700822023 @default.
• W1849270082 crossrefType "journal-article" @default.
• W1849270082 hasAuthorship W1849270082A5002661645 @default.
• W1849270082 hasAuthorship W1849270082A5025508358 @default.
• W1849270082 hasConcept C112592302 @default.
• W1849270082 hasConcept C12554922 @default.
• W1849270082 hasConcept C131453863 @default.
• W1849270082 hasConcept C147944092 @default.
• W1849270082 hasConcept C169760540 @default.
• W1849270082 hasConcept C170493617 @default.
• W1849270082 hasConcept C17077164 @default.
• W1849270082 hasConcept C178790620 @default.
• W1849270082 hasConcept C181911157 @default.
• W1849270082 hasConcept C185263204 @default.
• W1849270082 hasConcept C185592680 @default.
• W1849270082 hasConcept C195221683 @default.
• W1849270082 hasConcept C197341189 @default.
• W1849270082 hasConcept C2776919887 @default.
• W1849270082 hasConcept C2778071365 @default.
• W1849270082 hasConcept C2779652256 @default.
• W1849270082 hasConcept C2780019300 @default.
• W1849270082 hasConcept C4141045 @default.
• W1849270082 hasConcept C55493867 @default.
• W1849270082 hasConcept C66974803 @default.
• W1849270082 hasConcept C79879829 @default.
• W1849270082 hasConcept C83743174 @default.
• W1849270082 hasConcept C86803240 @default.

• next