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• W1849271410 endingPage "1235" @default.
• W1849271410 startingPage "1226" @default.
• W1849271410 abstract "The cellular mechanisms responsible for synaptic plasticity involve interactions between neurons and the extracellular matrix. Heparan sulfates (HSs) constitute a group of glycosaminoglycans that accumulate in the beta-amyloid deposits in Alzheimer's disease and influence the development of neuron-target contacts by interacting with other cell surface and matrix molecules. However, the contribution of HSs to brain function is unknown. We found that HSs play a crucial role in long-term potentiation (LTP), a finding that is consistent with the idea that converging molecular mechanisms are used in the development of neuron-target contacts and in activity-induced synaptic plasticity in adults. Enzymatic cleavage of HS by heparitinase as well as addition of soluble heparin-type carbohydrates prevented expression of LTP in response to 100 Hz/1 sec stimulation of Schaffer collaterals in rat hippocampal slices. A prominent carrier protein for the type of glycans implicated in LTP regulation in the adult hippocampus was identified as N-syndecan (syndecan-3), a transmembrane proteoglycan that was expressed at the processes of the CA1 pyramidal neurons in an activity-dependent manner. Addition of soluble N-syndecan into the CA1 dendritic area prevented tetanus-induced LTP. A major substrate of src-type kinases, cortactin (p80/85), and the tyrosine kinase fyn copurified with N-syndecan from hippocampus. Moreover, association of both cortactin and fyn to N-syndecan was rapidly increased after induction of LTP. N-syndecan may thus act as an important regulator in the activity-dependent modulation of neuronal connectivity by transmitting signals between extracellular heparin-binding factors and the fyn signaling pathway." @default.
• W1849271410 created "2016-06-24" @default.
• W1849271410 creator A5007863962 @default.
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• W1849271410 date "1999-02-15" @default.
• W1849271410 modified "2023-10-10" @default.
• W1849271410 title "Reg1ulatory Role and Molecular Interactions of a Cell-Surface Heparan Sulfate Proteoglycan (<i>N</i>-syndecan) in Hippocampal Long-Term Potentiation" @default.
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• W1849271410 doi "https://doi.org/10.1523/jneurosci.19-04-01226.1999" @default.
• W1849271410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6786044" @default.
• W1849271410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9952400" @default.
• W1849271410 hasPublicationYear "1999" @default.
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